Parental care influences leukocyte telomere length with gender specificity in parents and offsprings

Enokido, Masanori; Suzuki, Akihito; Sadahiro, Ryoichi; Matsumoto, Yoshihiko; Kuwahata, Fumikazu; Takahashi, Nana; Goto, Kaoru; Otani, Koichi

doi:10.1186/s12888-014-0277-9

Cited by 23 publications

(16 citation statements)

References 47 publications

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“…We found evidence of telomere shortening in both children with and without a history of institutional care. Consistent with our hypothesis and previous studies of both adults exposed to early caregiving adversity (Beach et al, 2014; Enokido et al, 2014; Kananen et al, 2010; Kiecolt-Glaser et al, 2011), and children exposed to maltreatment, family violence, or high family stress (Drury et al, 2014a, 2012; Gotlib et al, 2014; Shalev et al, 2012), we found exposure to early institutional caregiving resulted in accelerated telomere shortening across middle childhood and adolescence compared to children without any exposure to institutional caregiving.…”

Section: Discussionsupporting

confidence: 92%

“…Shorter TL has been associated with environmental stress exposure (e.g., neighborhood-level social environmental risk and prenatal tobacco exposure; Theall et al, 2013a, 2013b) and poor caregiving environments for the child (e.g., physical maltreatment, institutional care, poverty; Drury et al, 2012; Mitchell et al, 2014). High quality parental care may buffer the negative impact of adversity on TL (Asok et al, 2013; Enokido et al, 2014). In adults and adolescents, decreased TL has also been associated with cardiovascular disease (Saliques et al, 2010), diabetes (Willeit et al, 2014), and obesity (Müezzinler et al, 2014), all negative health outcomes linked with experiences of early adversity.…”

Section: Introductionmentioning

confidence: 99%

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Accelerated telomere shortening: Tracking the lasting impact of early institutional care at the cellular level

Humphreys

Esteves

Zeanah

et al. 2016

Psychiatry Research

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Studies examining the association between early adversity and longitudinal changes in telomere length within the same individual are rare, yet are likely to provide novel insight into the subsequent lasting effects of negative early experiences. We sought to examine the association between institutional care history and telomere shortening longitudinally across middle childhood and into adolescence. Buccal DNA was collected 2 to 4 times, between the ages of 6 and 15 years, in 79 children enrolled in the Bucharest Early Intervention Project (BEIP), a longitudinal study exploring the impact of early institutional rearing on child health and development. Children with a history of early institutional care (n=50) demonstrated significantly greater telomere shortening across middle childhood and adolescence compared to never institutionalized children (n=29). Among children with a history of institutional care, randomization to high quality foster care was not associated with differential telomere attrition across development. Cross-sectional analysis of children randomized to the care as usual group indicated shorter telomere length was associated with greater percent of the child’s life spent in institutional care up to age 8. These results suggest that early adverse care from severe psychosocial deprivation may be embedded at the molecular genetic level through accelerated telomere shortening.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Accelerated telomere shortening: Tracking the lasting impact of early institutional care at the cellular level

Humphreys

Esteves

Zeanah

et al. 2016

Psychiatry Research

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“…In addition to the above benefits for offspring condition and dominance acquisition, infanticide may therefore allow dominant females to improve pup telomere lengths, thus delaying their onset of senescence, extending their dominance tenures and increasing their lifetime reproductive success. While the level and type of parental care has been shown to influence offspring telomere lengths in humans and captive rhesus monkeys (Macaca mulatta) [30,71,72], to our knowledge this is the first evidence that a specific maternal strategy (killing competitor pups) has associated benefits for offspring telomere lengths.…”

Section: Discussionmentioning

confidence: 86%

Effects of early-life competition and maternal nutrition on telomere lengths in wild meerkats

et al. 2017

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Effects of early-life competition and maternal nutrition on telomere lengths in wild meerkats. Proceedings of the Royal Society of London Series B: Biological Sciences, 284(1861), 20171383. (doi:10.1098/rspb.2017.1383 This is the author's final accepted version.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/147697/ Here, we investigate the link between early-life competition and telomere length in wild 23 meerkats. Our results show that, when multiple females breed concurrently, increases in the 24 number of pups in the group are associated with shorter telomeres in pups. Given that pups 25 from different litters compete for access to milk, we tested whether this effect is due to 26 nutritional constraints on maternal milk production, by experimentally supplementing 27 females' diets during gestation and lactation. While control pups facing high competition had 28 shorter telomeres, the negative effects of pup number on telomere lengths were absent when 29 maternal nutrition was experimentally improved. Shortened pup telomeres were associated 30 with reduced survival to adulthood, suggesting that early-life competition for nutrition has 31 detrimental fitness consequences that are reflected in telomere lengths. Dominant females 32 commonly kill pups born to subordinates, thereby reducing competition and increasing 33 growth rates of their own pups. Our work suggests an additional benefit of infanticide may be 34 that it also reduces telomere shortening caused by competition for resources, with associated 35 benefits for offspring ageing profiles and longevity. 36 37 KEY WORDS 38telomeres, early-life adversity, early-life stress, Suricata suricatta, meerkats, infanticide 39 40 41Introduction 42

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“…Shalev and colleagues, investigating children, found that there was a relationship between exposure to two or more kinds of violence and shortened telomere length, although numbers in this subgroup were low (n = 39), so definitive conclusions cannot be drawn [9]. Enokido and colleagues [48] showed an association between parenting style and telomere length and also demonstrated a gender-specific response; however, this study involved healthy participants and relied on self-report.…”

Section: Telomere Studiesmentioning

confidence: 92%

Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature

Lang

McKie

Smith

et al. 2019

Eur Child Adolesc Psychiatry

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A systematic review following PRISMA guidelines was conducted to answer the question: What epigenetic, telomeric and associated biological changes are associated with exposure to adverse childhood experiences (ACEs) in the under 12s? Using PRISMA guidelines, appropriate databases were searched. 190 papers were returned with 38 articles fully reviewed. Articles were each independently quality rated by two authors using the Crowe Critical Appraisal Tool and data were extracted. Of the 38 articles, 23 were rated as very high quality. Most study participants were adults (n = 7769) with n = 727 child participants. Only seven of the very/high-quality studies were prospective and involved children. Methylation was the most studied method of epigenetic modification. There is some evidence supporting epigenetic modification of certain markers in participants exposed to ACEs measured in adulthood. Research is lacking on non-coding aspects of the epigenome and on coding aspects other than DNA methylation. There is some evidence of a more powerful effect on telomere length if physical neglect was involved. Much further work is required to model biological and psychological effects of epigenetic changes during childhood using prospective study designs. The effect of ACEs on the cellular ageing process during childhood is inadequately investigated and relies solely on measure of telomere length. Future research suggestions are proposed.

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Parental care influences leukocyte telomere length with gender specificity in parents and offsprings

Cited by 23 publications

References 47 publications

Accelerated telomere shortening: Tracking the lasting impact of early institutional care at the cellular level

Accelerated telomere shortening: Tracking the lasting impact of early institutional care at the cellular level

Effects of early-life competition and maternal nutrition on telomere lengths in wild meerkats

Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature

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