Parental control and the dopamine D2 receptor gene (DRD2) interaction on emotional eating in adolescence

Strien, Tatjana van; Snoek, Harriëtte M.; Zwaluw, Carmen S. van der; Engels, Rutger C. M. E.

doi:10.1016/j.appet.2009.11.006

Cited by 65 publications

(54 citation statements)

References 47 publications

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“…In a recent fMRI study investigating the effects of dopamine genotypes on reward in response to food, DRD2A1 and DRD4R7 risk alleles were associated with an attenuated activation of the reward circuitry in response to anticipated food intake and this predicted risk of future weight gain in female adolescents (Stice et al, 2010). Consistent with these data, DRD2 genotype appears to moderate the relationship between psychological control and emotional eating, where adolescents with at least one DRD2 A1 allele showed an increase in emotional eating in relation to high parental psychological control (van Strien et al, 2010). Additionally, there is evidence in female adolescents to suggest that symptoms of depression and dopamine transporter SLC6A3 genotype interact producing a synergistic increase in intake of high-energy sweet foods (Agurs-Collins & Fuemmeler, 2011).…”

Section: Reward Related Genes Food Intake and Eating Behavioural Traitssupporting

confidence: 74%

Obesity and eating behaviour in children and adolescents: Contribution of common gene polymorphisms

Cecil

Dalton

Finlayson

et al. 2012

International Review of Psychiatry

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The prevalence of childhood obesity is increasing in many countries and confers risks for early type 2 diabetes, cardiovascular disease and metabolic syndrome. In the presence of potent ' obesogenic ' environments not all children become obese, indicating the presence of susceptibility and resistance. Taking an energy balance approach, susceptibility could be mediated through a failure of appetite regulation leading to increased energy intake or via diminished energy expenditure. Evidence shows that heritability estimates for BMI and body fat are paralleled by similar coeffi cients for energy intake and preferences for dietary fat. Twin studies implicate weak satiety and enhanced food responsiveness as factors determining an increase in BMI. Single gene mutations, for example in the leptin receptor gene, that lead to extreme obesity appear to operate through appetite regulating mechanisms and the phenotypic response involves overconsumption and a failure to inhibit eating. Investigations of robustly characterized common gene variants of fat mass and obesity associated ( FTO ), peroxisome proliferator-activated receptor ( PPARG ) and melanocortin 4 receptor ( MC4R ) which contribute to variance in BMI also infl uence the variance in appetite factors such as measured energy intake, satiety responsiveness and the intake of palatable energy-dense food. A review of the evidence suggests that susceptibility to childhood obesity involving specifi c allelic variants of certain genes is mediated primarily through food consumption (appetite regulation) rather than through a decrease in activity-related energy expenditure. This conclusion has implications for early detection of susceptibility, and for prevention and management of childhood obesity.

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Section: Reward Related Genes Food Intake and Eating Behavioural Traitssupporting

confidence: 74%

Obesity and eating behaviour in children and adolescents: Contribution of common gene polymorphisms

Cecil

Dalton

Finlayson

et al. 2012

International Review of Psychiatry

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“…[53] Bağımlılıkla ilgili yapılan araştırmalara paralel olarak yapılan birçok genetik araştırmada homojen ve heterojen örneklemlerde A1 aleli artmış obesite riski ve tıkınırcasına yeme bozukluğu gibi farklı yeme bozuklukları ile de iliş-kili bulunmuştur. [54][55][56] Araştırmalarda A1 aleli olan bireylerin daha fazla yiyecek aşerdiği ve yiyecekle ilgili görevlerde daha fazla zaman harcadıkları ve daha çok yemek yedikleri gösterilmiştir. [57] Ebstein ve arkadaşları A1 aleli ile yiyeceklerin ödül beklentisi (food anticipatory reward) arasında da ilişki saptamışlardır ve aynı zamanda yiyeceklere olan isteği artmış olan kişilerde de A1 aleli olduğunu görmüşlerdir.…”

Section: Genetik Araştırmalarunclassified

Etiology of Food Addiction

Öyekçin¹,

Deveci²

2012

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖZETYeme bağımlılığı kavramı bilimsel literatürde son yıllarda gündemde olan bir kavramdır. Özellikle obez ve aşırı yemek yiyen kişilerde yemenin bir tür bağımlılığa dönüşebildiği ileri sürülmekte ve bu kişilerde gözlenen davranışların bağımlılıkta sıklıkla gözlenen temel belirtilerle örtüşebildiği belirtilmektedir. Yapılan laboratuvar, epidemiyolojik, klinik ve genetik araştırmaların sonuçları yeme bağımlılığı modelinin klinik geçerliliğini kısmen gösterse de nörobiyolojik araştırmalar daha çok obezite ve madde bağımlılığında ödül sisteminde ortaya çıkan benzerlikleri ortaya koymaktadır. Araştırmaların bir bölümü ise halen belirgin farklılıkların olduğuna vurgu yapmaktadır. Bu derleme yazısında yeme bağımlılığı kavramının klinik ve biyolojik özellikleri etyolojik açıdan ele alınmış ve bu konuda yapılan ağırlıklı olarak preklinik, klinik ve genetik araştırmaların gözden geçirilmesi amaçlanmıştır. Anahtar Sözcükler: Etiyoloji, yeme bağımlılığı, nörobiyoloji ABSTRACT Food addiction is a new topic of focus in the scientific literature. Food intake might be concerned as food addiction in some cases, especially in obese cases and over-eaters. Addiction like behaviours are commonly observed mong these people. Recent animal, epidemiological, clinical and genetic studies partly shows the clinical validity of food addiction while the neurobiological studies focused on the similarity between the reward systems present in obesity and drug addiction. However some studies still emphasizes the differences between two. The aim of this article was to review clinical and biological aspects of etiological perspectives of food addiction via available clinical, preclinical and genetic studies. Keywords: Etiology, food addiction, neurobiology eme bağımlılığı (food addiction), son yıllarda gündemde olan ve hakkındaki literatür giderek artan bir kavramdır. Özellikle obezitede ve aşırı yemek yiyen kişilerde yeme bağımlılığının olabileceği ileri sürül-Y

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“…For example, in two studies with Turkish obese children the variant allele frequency was 51.0% in one 57 and only 20.0% in the other research. 58 In the Netherlands, the A1 allele frequency was 18.3% in obese children 59 and in NorthAmerican studies with obese children, it ranged from 17.0% 60 to 38.5%. 61 In a Brazilian study with obese and normal weight (controls) children, the A1 allele frequencies were 34.5% and 23.0%, respectively, and a statistically significant association between the A1 allele and obesity was verified.…”

Section: Drd2 Taqia Polymorphismmentioning

confidence: 99%

Basic and Genetic Aspects of Food Intake Control and Obesity: Role of Dopamin Receptor D2 TaqIA Polymorphism

Pinto¹,

Cominetti²,

Cruz³

2016

Obes Res Open J

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Regulation of food intake, energy expenditure and store are strikingly linked to obesity. Homeostatic control of food intake, hunger and satiety involves adipose and gastrointestinal hormones, such as leptin, insulin and ghrelin, which eventually affect neuronal signaling in the hypothalamus arcuate nucleus. On the other hand, hedonic control of food intake relates to substances such as opioids, endocannabinoids, gamma-aminobutyric acid, serotonin and dopamine, which act on the motivation and reward mechanisms. Dopamine is a precursor of noradrenaline and adrenaline and modulates a number of physiological functions, such as appetite, depending on the brain area and the type of receptor stimulated. It has been established as the main neurotransmitter of the hypothalamic reward system. Beyond the homeostatic and hedonic energy balance control, genetic aspects are also tightly involved in obesity pathophysiology. In this context, some Single Nucleotide Polymorphism (SNP) has been linked to common obesity. Here, we highlight the role of the dopamine receptor D2 gene TaqAI polymorphism, which affects the D2 receptor availability and has been associated to obesity. Therefore, the aim of this mini review is to cover basic aspects of food intake, energy balance, dopamine-related aspects, including genetic ones, and the relation with obesity.

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Parental control and the dopamine D2 receptor gene (DRD2) interaction on emotional eating in adolescence

Cited by 65 publications

References 47 publications

Obesity and eating behaviour in children and adolescents: Contribution of common gene polymorphisms

Obesity and eating behaviour in children and adolescents: Contribution of common gene polymorphisms

Etiology of Food Addiction

Basic and Genetic Aspects of Food Intake Control and Obesity: Role of Dopamin Receptor D2 TaqIA Polymorphism

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