Parental exposure to waterborne selenite induces transgenerational development toxicity in zebrafish offspring

Chronic Paternal/Maternal Exposure to Environmental Concentrations of Imidacloprid and Thiamethoxam Causes Intergenerational Toxicity in Zebrafish Offspring

“…Several studies also provide evidences that toxicants transmitted through maternal exposure cause developmental toxicity in offspring, 74,75 and others have found decreased sperm quality following toxicant exposure leading to DNA damage in F1 offspring. 25,76 In the present study, adverse reproductive and endocrine effects in zebrafish directly exposed to IMI or THM (F0), as well as intergenerational effects on unexposed offspring (F1) through both the paternal and maternal lines. Second, similar transcription of several biomarkers in both F0 gonads and F1 generations further support that both paternal and maternal exposure to IMI and THM had considerable effects on endocrine-disrupting effects in F1 generation fish (Figure 5A).…”

“…Transgenerational effects occur when the physiology, development, and endocrinology of offspring are influenced by environmental alterations experienced by the parents before fertilization . The toxic effects of parental exposure are transferred intergenerationally from exposed males or females to unexposed offspring, affecting the development of F1 zebrafish larval offspring in a gender-specific manner. , Studies indicate that parents who are chronically exposed to polluted environments have adverse transgenerational effects on their offspring. In terms of molecular mechanism, long non-coding RNA (lncRNA) plays an important role in the transgenerational inheritance in fish.…”