Parental history of lupus and rheumatoid arthritis and risk in offspring in a nationwide cohort study: does sex matter?

Somers, Emily C.; Antonsen, Steen; Pedersen, Lars; Sørensen, Henrik Toft

doi:10.1136/annrheumdis-2011-201165

Cited by 33 publications

(19 citation statements)

References 53 publications

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“…Koumantaki et al reported an odds ratio for developing RA of 4.4 for a first‐degree relative with RA (). Somers et al reported an HR of 2.7 for RA in female offspring with a maternal history of RA (). Frisell et al recently reported an odds ratio of 3.2 for RA from a first‐degree relative with RA ().…”

Section: Discussionsupporting

confidence: 55%

Contributions of Familial Rheumatoid Arthritis or Lupus and Environmental Factors to Risk of Rheumatoid Arthritis in Women: A Prospective Cohort Study

Sparks

Chen

Hiraki

et al. 2014

Arthritis Care & Research

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Objective We assessed the contributions of familial rheumatoid arthritis (RA) or lupus and environmental factors to risk of RA. Methods Among 121,700 women in the Nurses’ Health Study, 65,457 provided data on familial RA/lupus. Among these, 493 RA cases (301 seropositive and 192 seronegative) were validated. We estimated hazard ratios (HR) for RA comparing those with and without familial RA/lupus, adjusting for environmental factors (smoking, alcohol, body mass index [BMI], parity, breastfeeding, menopause, hormone use, early menarche, and menstrual regularity) using Cox proportional hazards models. Population attributable risks (PAR) for RA within this cohort were calculated for familial RA/lupus, smoking, alcohol, BMI, parity, and breastfeeding. Results Familial RA/lupus was significantly associated with RA (HR 3.67), seropositive RA (HR 3.90) and seronegative RA (HR 3.95). After adjusting for environmental factors, familial RA/lupus was significantly associated with RA (HR 3.59, 95% confidence interval 2.94–4.37). Smoking >10 pack-years, alcohol intake 5–10 g/day, overweight, breastfeeding ≥12 months, and pre-menopausal status remained significantly associated with RA after adjusting for familial RA/lupus. For RA in this cohort, the PAR for smoking, BMI, alcohol, parity, or breastfeeding collectively was 41%; the PAR due to heredity from familial RA/lupus was 21%. Conclusion In this large, prospective cohort, women with familial RA/lupus had a four-fold increased risk for RA that remained significant after adjusting for environmental factors. A large proportion of RA risk was attributable to environmental factors even among those with familial RA/lupus.

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Section: Discussionsupporting

confidence: 55%

Contributions of Familial Rheumatoid Arthritis or Lupus and Environmental Factors to Risk of Rheumatoid Arthritis in Women: A Prospective Cohort Study

Sparks

Chen

Hiraki

et al. 2014

Arthritis Care & Research

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“…The advantage of defining different phases may provide a framework for identifying risk factors in a temporary course. Epidemiological studies based on populations have shown that having a family history of RA increases the risk of having arthritis approximately 2‐3 times with a greater risk in FDR . The preclinical phase is relevant to understand the development of RA; therefore, our interest to study this group of individuals is in line with a recent paper that found that obesity, ACPAs and periodontitis may be relevant conditions associated with the development of RA in FDR …”

Section: Discussionmentioning

confidence: 76%

Association of adipokines with rheumatic disease activity indexes and periodontal disease in patients with early rheumatoid arthritis and their first‐degree relatives

et al. 2019

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Objective:To evaluate the adipokine levels in early rheumatoid arthritis (eRA) and first-degree relatives (FDR) of patients with RA and establish their association with rheumatic disease activity and periodontal variables. Method:A cross-sectional study with eRA patients, FDR and a healthy population.Adipokine levels, clinical, joint radiological indexes and periodontal variables were evaluated. A descriptive, bivariate analysis was performed based on the adipokine levels by χ 2 , Fisher's test and Mann-Whitney U test. A logistic regression was made for associations. Results:High leptin levels were associated with the diagnosis of eRA (odds ratio[OR] = 2.79; 95% CI 1.54-5.07). Early rheumatoid arthritis with high adiponectin levels was less likely to have Multidimensional Health Assessment Questionnaire score >3, body mass index (BMI) >25 and Routine Assessment of Patient Index Data 3 score >12 (OR = 0.16; 95% CI 0.03-0.72). Early rheumatoid arthritis was more likely to present high leptin and interleukin (IL)6 levels with low adiponectin simultaneously (OR = 5.03; 95% CI 1.05-24.0). High leptin levels were associated with the FDR adjusted for IgG2 Porphyromonas gingivalis, swollen joints, P gingivalis and low IL6 (OR = 2.57; 95% CI 1.14-5.95). Conclusion:High adipokine levels in eRA may modulate the disease activity. Having more than 1 adipokine at high serum levels is associated with increased disability, disease activity and BMI, indicating that RA is controlled by adiponectin levels in the early stages of the disease. High leptin levels, presence of P gingivalis and swollen joints may be the factors associated with the development of RA in FDR. K E Y W O R D Sadipokines, adiponectin, leptin, periodontitis, rheumatoid arthritis | 1991 CHAPARRO-SANABRIA et Al.

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“…[18][19][20][21][22][23][24][25][26][27][28][29][30] Individuals with a family history (FH) of autoimmunity are at particularly increased RA risk, probably owing to shared environment and genetics. [31][32][33] RA prevention remains an elusive goal given its relatively low prevalence and unclear transitions between preclinical phases and clinical disease. 34 35 Preclinical RA prevention efforts targeted at people at increased risk may overcome these challenges.…”

Section: Introductionmentioning

confidence: 99%

Improved performance of epidemiologic and genetic risk models for rheumatoid arthritis serologic phenotypes using family history

et al. 2014

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Objective To develop and validate rheumatoid arthritis (RA) risk models based on family history, epidemiologic factors, and known genetic risk factors. Methods We developed and validated models for RA based on known RA risk factors, among women in two cohorts: the Nurses’ Health Study (NHS, 381 RA cases and 410 controls) and the Epidemiological Investigation of RA (EIRA, 1244 RA cases and 971 controls). Model discrimination was evaluated using the area under the receiver operating characteristic curve (AUC) in logistic regression models for the study population and for those with positive family history. The joint effect of family history with genetics, smoking, and body mass index (BMI) was evaluated using logistic regression models to estimate odds ratios (OR) for RA. Results The complete model including family history, epidemiologic risk factors, and genetics demonstrated AUCs of 0.74 for seropositive RA in NHS and 0.77 for anti-citrullinated protein antibody (ACPA)-positive RA in EIRA. Among women with positive family history, discrimination was excellent for complete models for seropositive RA in NHS (AUC 0.82) and ACPA-positive RA in EIRA (AUC 0.83). Positive family history, high genetic susceptibility, smoking, and increased BMI had an OR of 21.73 for ACPA-positive RA. Conclusions We developed models for seropositive and seronegative RA phenotypes based on family history, epidemiologic and genetic factors. Among those with positive family history, models utilizing epidemiologic and genetic factors were highly discriminatory for seropositive and seronegative RA. Assessing epidemiological and genetic factors among those with positive family history may identify individuals suitable for RA prevention strategies.

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Parental history of lupus and rheumatoid arthritis and risk in offspring in a nationwide cohort study: does sex matter?

Cited by 33 publications

References 53 publications

Contributions of Familial Rheumatoid Arthritis or Lupus and Environmental Factors to Risk of Rheumatoid Arthritis in Women: A Prospective Cohort Study

Contributions of Familial Rheumatoid Arthritis or Lupus and Environmental Factors to Risk of Rheumatoid Arthritis in Women: A Prospective Cohort Study

Association of adipokines with rheumatic disease activity indexes and periodontal disease in patients with early rheumatoid arthritis and their first‐degree relatives

Improved performance of epidemiologic and genetic risk models for rheumatoid arthritis serologic phenotypes using family history

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