Parental longevity predicts healthy ageing among women

Shadyab, Aladdin H.; Manson, JoAnn E.; Li, Wenjun; Gass, Margery; Brunner, Robert L.; Naughton, Michelle J.; Cannell, Brad; Howard, Barbara V.; LaCroix, Andrea Z.

doi:10.1093/ageing/afy125

Cited by 11 publications

(22 citation statements)

References 30 publications

(66 reference statements)

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“…Several previous studies have found that individuals with long-lived parents tend to age healthier [3,29]. Parental longevity influences aging not only because of genetics, but also because of shared lifestyle and environmental factors [3]. Results from a recent study from the Women's Health Initiative found that having a mother that achieved HA correlated with HA in postmenopausal women (OR, 1.25; 95% CI, 1.11-1.42) [3].…”

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

“…We additionally studied HA at 90 because this is the usual reference for longevity studies [3,23]. Participants who did not reach age 77 or developed the chronic age-associated conditions defined previously were considered to undergo normal aging.…”

Section: Study Outcomementioning

confidence: 99%

“…Previous studies in Europe and US have found that a combination of genetic and lifestyle factors plays a critical role in HA [2][3][4][5][6][7]. Prior studies in Caucasian populations showed that individuals with long-lived parents tend to be healthy agers [3,8], and some studies have found associations with the Apolipoprotein E (APOE) gene [8]. Evidence regarding lifestyle factors (such as physical activity, non-smoking, low alcohol consumption, maintaining a healthy weight) shows consistent associations with successful aging; however, most of these studies have been performed in Caucasian and Asian populations [5,7,9,10].…”

Section: Introductionmentioning

confidence: 99%

“…Attaining healthy aging (HA) has become a public health challenge, and it is fundamental to identify the variables that are associated with it. Previous studies in Europe and US have found that a combination of genetic and lifestyle factors plays a critical role in HA [2][3][4][5][6][7]. Prior studies in Caucasian populations showed that individuals with long-lived parents tend to be healthy agers [3,8], and some studies have found associations with the Apolipoprotein E (APOE) gene [8].…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with healthy aging in septuagenarian and nonagenarian Mexican adults

2020

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To examine the factors associated with healthy aging in a cohort of Mexican adults after a follow-up of 14 years. Study design: Participants were part of a prospective cohort of the Mexican Healthy Aging Study (MHAS), from which we included 5142 individuals aged 63 years or more. Main outcome: Healthy aging, defined as reaching age 77 or 90 without major chronic conditions or physical limitations. Measures: Information on age, education, marital status, smoking, alcohol consumption, physical activity, selfperceived depression, health conditions and history of age-related diseases was collected at baseline and followup. Results: Among the overall cohort, 57.8% experienced healthy survival to age 77 and 42.2% had died before age 77 or were undergoing normal aging. Participants with long-lived parents and who exercised had a lower risk of being non-healthy agers. Being overweight, obese or a smoker increased the risk of being a non-healthy ager. Physically active participants had increased odds of healthy aging at age 77 (OR: 1.17; 95% CI: 1.01-1.46) and at age 90 (OR: 1.5; 95% CI: 1.01-2.24). Depression had a negative relationship with healthy aging at age 90 (OR: 0.66; 95% CI: 0.45-0.97). Maternal longevity was associated with healthy aging only at age 77 (OR = 1.34; 95% CI: 1.04-1.72). Conclusions: Our findings support the view that a combination of genetic and behavioral factors is associated with healthy aging. In accordance with findings in Caucasian populations, our data suggest for the first time that there might also be a genetic determinant for healthy ageing in Latin Americans.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Study Outcomementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Factors associated with healthy aging in septuagenarian and nonagenarian Mexican adults

2020

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A phenome‐wide investigation of risk factors for severe COVID‐19

Baranova

Cao

Teng

et al. 2022

Journal of Medical Virology

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With the continued spread of COVID‐19 globally, it is crucial to identify the potential risk or protective factors associated with COVID‐19. Here, we performed genetic correlation analysis and Mendelian randomization analysis to examine genetic relationships between COVID‐19 hospitalization and 405 health conditions and lifestyle factors in 456 422 participants from the UK Biobank. The genetic correlation analysis revealed 134 positive and 65 negative correlations, including those with intakes of a variety of dietary components. The MR analysis indicates that a set of body fat‐related traits, maternal smoking around birth, basal metabolic rate, lymphocyte count, peripheral enthesopathies and allied syndromes, blood clots in the leg, and arthropathy are causal risk factors for severe COVID‐19, while higher education attainment, physical activity, asthma, and never smoking status protect against the illness. Our findings have implications for risk stratification in patients with COVID‐19 and the prevention of its severe outcomes.

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The relationship of parental longevity with the aging brain—results from UK Biobank

et al. 2020

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A few studies report that parental longevity is associated with preserved cognition and physical function and lower risk of Alzheimer's disease. However, data on structural neuroimaging correlates of parental longevity and its spatial distribution are limited. This study aims to examine relationships of parental longevity with regional brain structure and to explore sex differences. We identified 12,970 UK Biobank participants (mean age=64.4, 51.5%women) with data on parental longevity, regional gray matter volumes, and white matter microstructure. Participants were categorized based on whether at least one parent lived to age 85 or older or neither parent survived to age 85. Associations of parental longevity, maternal and paternal longevity with each neuroimaging marker of interest were examined using linear regression, adjusted for demographics, APOE e4 status, lifestyle, and cardiometabolic conditions.Compared to participants whose both parents died before 85 (43%), those with at least one parent surviving to 85 (57%) had greater volumes in hippocampus, parahippocampal gyrus, middle temporal lobe, and primary sensorimotor cortex, and had lower mean diffusivity in posterior thalamic radiation and uncinate fasciculus. Associations were prominent with maternal longevity. Adjustment for cardiometabolic conditions did not affect observed associations except mean diffusivity in posterior thalamic radiation. There were no structural differences in other areas. Parental longevity is associated with preserved brain structure localized in primary sensorimotor cortex and temporal areas including hippocampus. These relationships are prominent with maternal longevity. Longitudinal studies are needed to determine whether changes in these brain structures account for the association between parental longevity and dementia.

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Parental longevity predicts healthy ageing among women

Abstract: parental longevity predicted healthy ageing in a national cohort of postmenopausal women, supporting the view that genetic, environmental, and behavioral factors transmitted across generations may influence ageing outcomes among offspring.

Cited by 11 publications

References 30 publications

Factors associated with healthy aging in septuagenarian and nonagenarian Mexican adults

Factors associated with healthy aging in septuagenarian and nonagenarian Mexican adults

A phenome‐wide investigation of risk factors for severe COVID‐19

The relationship of parental longevity with the aging brain—results from UK Biobank

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