Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium

Bailey, Helen D.; Fritschi, Lin; Metayer, Catherine; Infante‐Rivard, Claire; Magnani, Corrado; Petridou, Eleni; Roman, Eve; Spector, Logan G.; Kaatsch, Peter; Clavel, Jacqueline; Milne, Elizabeth; Dockerty, John D.; Glass, Deborah Catherine; Lightfoot, Tracy; Miligi, Lucia; Rudant, Jérémie; Baka, Margarita; Rondelli, Roberto; Amigou, Alicia; Simpson, Jill; Kang, Alice Y.; Moschovi, Maria; Schüz, Joachim

doi:10.1007/s10552-014-0441-z

Cited by 31 publications

(24 citation statements)

References 25 publications

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“…For childhood leukaemia, The majority of more recent studies have also reported increased risks associated with benzene-related occupational exposures, either for paternal (Feychting et al 2001;Metayer et al 2016;Miligi et al 2013;Reid et al 2011) or maternal exposure (Infante-Rivard et al 2005;McKinney et al 2008;Miligi et al 2013;Reid et al 2011;Schuz et al 2000;Shu et al 1999). However, two large recent studies (Bailey et al 2014;Keegan et al 2012), including a study of 5 the Childhood Leukaemia International Consortium (CLIC) focusing on parental occupational exposure to paint (Bailey et al 2014), found no evidence of an association. Most previous studies looked at broad occupational or substance groups while only a minority considered exposure to benzene specifically.…”

Section: Introductionmentioning

confidence: 99%

Parental occupational exposure to benzene and the risk of childhood cancer: A census-based cohort study

Spycher

Lupatsch

Huss

et al. 2017

Environment International

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Background: Previous studies on occupational exposures in parents and cancer risks in their children support a link between solvents and paints with childhood leukaemia. Few studies have focused specifically on benzene.Objectives: To examine whether parental occupational exposure to benzene is associated with an increased cancer risk in a census-based cohort of children.Methods: From a census-based cohort study in Switzerland, we included children aged <16 years at national censuses (1990, 2000). We retrieved parental occupations reported at census and assessed exposure to benzene using a job exposure matrix. We identified incident cancer cases through record linkage with the Swiss Childhood Cancer Registry. We fitted Cox proportional-hazards models to assess associations between exposures and the following outcomes: any cancer, leukaemia, acute lymphoid leukaemia (ALL), acute myeloid leukaemia (AML), lymphoma, non-Hodgkin lymphoma, CNS tumours, and glioma. We adjusted models for a range of socio-economic, perinatal and environmental factors.Results: Analyses of maternal (paternal) exposure were based on 9.0 (13.2) million person years at risk and included 1004 (1520) diagnoses of cancer, of which 285 (438) had leukaemia, 186 (281) lymphoma, 227 (339) a CNS tumour. Maternal exposure was associated with an increased risk of childhood leukaemia (hazard ratio 1.73, 95% CI 1.12-2.67) and ALL (1.88, 1.16-3.04). We found little evidence of an association for other outcomes or for paternal exposure. Adjusting for potential confounders did not materially affect the results.Conclusions: This nationwide cohort study suggests an increased risk of leukaemia among children whose mothers were exposed to benzene at work. Highlights: A job exposure matrix was used to assess occupational benzene exposure in parents  A higher risk of leukaemia was observed in offspring of exposed mothers  In utero exposure is a plausible explanation for this finding

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Section: Introductionmentioning

confidence: 99%

Parental occupational exposure to benzene and the risk of childhood cancer: A census-based cohort study

Spycher

Lupatsch

Huss

et al. 2017

Environment International

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“…Previous epidemiologic studies have reported associations between parental occupational exposures to solvents, paints, pigments, pesticides, lead, combustion exhaust and the risk of childhood leukemia (Infante-Rivard et al, 2005; McKinney et al, 2008; Reid et al, 2011; Van Maele-Fabry et al., 2011; Vinson et al, 2011; Wigle et al, 2009). Most studies relied on job titles lacking specificity for type and intensity of exposure, and/or had a small sample size (Colt and Blair, 1998; Van Maele-Fabry et al, 2011; Vinson et al, 2011; Wigle et al, 2009; Keegan et al, 2012; Bailey et al, 2014a, 2014b). Few studies used expert occupational exposure assessment (Infante-Rivard et al, 2005; McKinney et al., 2008; Reid et al, 2011; Monge et al, 2007; Perez-Saldivar et al, 2008; Miligi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

A task-based assessment of parental occupational exposure to organic solvents and other compounds and the risk of childhood leukemia in California

Metayer

Scélo

Kang

et al. 2016

Environmental Research

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Purpose Data on parental occupational exposures and risk of childhood leukemia lack specificity. Using 19 task-based job modules, we examined the relationship between occupational exposure to organic solvents and other compounds and the risk of leukemia in children. Methods Latino (48%) and non-Latino (52%) children with acute lymphoblastic leukemia (ALL; n=670), acute myeloid leukemia (AML; n=104), and controls (n=1021) were enrolled in a study in California (2000–2008). Logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for socio-demographic factors. Results Among children with non-Latino fathers, none of the exposures evaluated were associated with risks of ALL and AML. In contrast, exposure to any organic solvents in Latino fathers was associated with an increased risk of childhood ALL (OR=1.48; 95% CI: 1.01–2.16); in multivariable analyses, the OR for chlorinated hydrocarbons was 2.28 (95% CI: 0.97–5.37) while the ORs were close to one for aromatic hydrocarbons, glycol ethers, and other hydrocarbon mixtures. We also observed an increased risk of ALL with exposure to combustion exhaust/polycyclic aromatic hydrocarbons (PAHs) (ORs=1.70; 95% CI: 1.16–2.57, and 1.46; 95% CI: 0.94–2.26 with and without adjustment for chlorinated hydrocarbons, respectively). Moderately elevated risks of ALL were seen with exposure to metals, paints, and wood dust, although not statistically significant. An increased risk was reported for asbestos based on small numbers of exposed Latino fathers. No associations were reported between maternal exposures to any exposures and childhood ALL and AML. Conclusions Our data support associations between paternal occupational exposures to chlorinated hydrocarbons, combustion exhaust, metals, and possibly asbestos and the risk of ALL in the children of Latino fathers only.

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“…The focus of these analyses was to investigate home paint exposure in relation to ALL. We have previously published findings of pooled analyses investigating parental occupational exposure to paints and the risk of childhood ALL using data from CLIC studies and found no association with paternal occupational exposure around conception, but had insufficient statistical power to investigate maternal occupational exposure during pregnancy (3). …”

Section: Introductionmentioning

confidence: 99%

Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium

Bailey

Metayer

Milne

et al. 2015

Cancer Causes Control

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Purpose It has been suggested that home paint exposure increases the risk of childhood acute lymphoblastic leukemia (ALL). Methods We obtained individual level data from eight case-control studies participating in the Childhood Leukemia International Consortium. All studies had home paint exposure data (sometimes including lacquers and varnishes) for the pregnancy period with additional data for the 1–3 month period before conception in five, the year before conception in two, and the period after birth in four studies respectively. Cytogenetic subtype data were available for some studies. Data were harmonized to a compatible format. Pooled analyses of individual data were undertaken using unconditional logistic regression. Results Based on 3,002 cases and 3,836 controls, the pooled odds ratio (OR) for home paint exposure in the 1–3 months before conception and risk of ALL was 1.54 (95% confidence interval (CI) 1.28, 1.85), while based on 1160 cases and 1641 controls for exposure in the year before conception it was 1.00 (95% CI 0.86, 1.17). For exposure during pregnancy, using 4,382 cases and 5,747 controls, the pooled OR was 1.14 (95% CI 1.04, 1.25) and for exposure after birth, the OR was 1.22 (95% CI 1.07, 1.39), based on data from 1,962 cases and 2,973 controls. The risk was greater for certain cytogenetic subtypes and if someone other than the parents did the painting. Conclusions Home paint exposure shortly before conception, during pregnancy and/or after birth appeared to increase the risk of childhood ALL. It may be prudent to limit exposure during these periods.

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Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium

Cited by 31 publications

References 25 publications

Parental occupational exposure to benzene and the risk of childhood cancer: A census-based cohort study

Parental occupational exposure to benzene and the risk of childhood cancer: A census-based cohort study

A task-based assessment of parental occupational exposure to organic solvents and other compounds and the risk of childhood leukemia in California

Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium

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