Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: Findings from the childhood leukemia international consortium

Bailey, Helen D.; Fritschi, Lin; Infante‐Rivard, Claire; Glass, Deborah Catherine; Miligi, Lucia; Dockerty, John D.; Lightfoot, Tracy; Clavel, Jacqueline; Roman, Eve; Spector, Logan G.; Kaatsch, Peter; Metayer, Catherine; Magnani, Corrado; Milne, Elizabeth; Polychronopoulou, Sophia; Simpson, Jill; Rudant, Jérémie; Sidi, V.; Rondelli, Roberto; Orsi, Laurent; Kang, Alice Y.; Petridou, Eleni; Schüz, Joachim

doi:10.1002/ijc.28854

Cited by 93 publications

(76 citation statements)

References 37 publications

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“…13 For example, in a recent meta-analysis comprised 1,329 leukemia cases and 12,141 controls, Bailey et al described a doubled risk of childhood AML on maternal pesticides exposure during pregnancy. 29 Ferreira et al 11 also indicated 3.5 fold increased risk for AML in Brazilian children, on maternal exposure to organophosphate at different time points of pregnancy.…”

Section: Discussionmentioning

confidence: 93%

In Utero Pesticides Exposure and Generation of Acute Myeloid Leukemia Associated Translocation (8; 21)

Ba¹

2016

MOJT

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This study aimed to detect the relationship between prenatal exposure to organophosphate and organo chlorine pesticides and development of translocation (8;21); in an Egyptian population between 2010-2012. Malathion, Diazinon, DDT, and Lindane were detected in meconium by gas chromatography-mass spectrometry (GC-MS). T (8; 21) was detected by RT-PCR on RNA extracted from cord blood. Thirty eight (20%) out of 190 of the cord blood samples were positive for t (8;21). Chi square tests were used to assess differences in the frequency of pesticide exposure in t (8;21) carriers vs. non carriers and the risk estimates were assessed using binary logistic regression. The frequency of prenatal Malathion exposure was61, and 36% in newborn t (8;21) carriers and non-carriers, respectively, (OR 2.78, 95%CI 1.34-5.77). The frequency of exposure was 58 and 41% for Diazinon (OR 1.94, 95%CI 0.95-3.99), 79 and 51% for DDT (OR 3.55,) and 55 and 49% for Lindane (OR 1.32, 95%CI 0.63-2.66). Rural residents showed a higher frequency of translocation than the urban; 23.6% of the rural were carriers versus only 3%forthe urban, (P=0.007). Rural residents showed a 10 fold increased risk to develop the fusion Oncogene. Prenatal exposure to organophosphate and organochlorine is potentially related to the generation of t (8;21) in the cord blood of apparently healthy newborns. Residing in rural areas imparts a higher risk for carrying such translocation.Keywords: prenatal, organophosphate, organochlorine, gc-ms, leukemia, translocation (8;21) MOJ Toxicology Research Article Open AccessIn utero pesticides exposure and generation of acute myeloid leukemia associated translocation (8; 21)

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Section: Discussionmentioning

confidence: 93%

In Utero Pesticides Exposure and Generation of Acute Myeloid Leukemia Associated Translocation (8; 21)

Ba¹

2016

MOJT

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“…Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have indicated an increased risk of leukaemia in the offspring. Bailey et al (2014) pooled data from 13 case-control studies participating in the Childhood Leukaemia International Consortium (CLIC) and found a significant increased risk of acute myeloid leukaemia (AML) in children born from mothers exposed to pesticides during pregnancy (OR: 1.94; 95% CI: 1.19-3.18), which is consistent with previous meta-analyses; however, no significant risk was found for paternal exposure around conception (OR: 0.91; 95% CI: 0.66-1.24). In relation to acute lymphocytic leukaemia (ALL), Bailey et al (2014) observed a 20% increased risk with paternal exposure around conception (OR: 1.20; 95% CI: 1.06-1.38), which appeared to be more evident for children with T-cell ALL; however, no association was found between maternal exposure during pregnancy and risk of ALL (OR: 1.01; 95% CI: 0.78-1.30).…”

Section: Epidemiological Studies Linking Pesticide Exposure With Chilmentioning

confidence: 99%

Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

Ockleford¹,

Adriaanse²,

Berny³

et al. 2017

EFS2

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In 2013, EFSA published a literature review on epidemiological studies linking exposure to pesticides and human health outcome. As a follow up, the EFSA Panel on Plant Protection Products and their residues (PPR Panel) was requested to investigate the plausible involvement of pesticide exposure as a risk factor for Parkinson's disease (PD) and childhood leukaemia (CHL). A systematic literature review on PD and CHL and mode of actions for pesticides was published by EFSA in 2016 and used as background documentation. The Panel used the Adverse Outcome Pathway (AOP) conceptual framework to define the biological plausibility in relation to epidemiological studies by means of identification of specific symptoms of the diseases as AO. The AOP combines multiple information and provides knowledge of biological pathways, highlights species differences and similarities, identifies research needs and supports regulatory decisions. In this context, the AOP approach could help in organising the available experimental knowledge to assess biological plausibility by describing the link between a molecular initiating event (MIE) and the AO through a series of biologically plausible and essential key events (KEs). As the AOP is chemically agnostic, tool chemical compounds were selected to empirically support the response and temporal concordance of the key event relationships (KERs). Three qualitative and one putative AOP were developed by the Panel using the results obtained. The Panel supports the use of the AOP framework to scientifically and transparently explore the biological plausibility of the association between pesticide exposure and human health outcomes, identify data gaps, define a tailored testing strategy and suggests an AOP's informed Integrated Approach for Testing and Assessment (IATA).

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“…19 Maternal occupational exposure to pesticides also increased the risk of childhood AML, whereas preconception paternal exposure slightly increased the risk of childhood ALL. 17 These findings are derived, for the most part, from other meta-analyses of published data. 32 -34 Childhood leukemia studies using dust samples and geographic information systems to assess indoor and outdoor pesticide exposure have S47 by guest on May 11, 2018 http://pediatrics.aappublications.org/ Downloaded from reported associations with specific types of pesticides based on target pest, phytochemical characteristics, or carcinogenicity.…”

Section: Pesticidesmentioning

confidence: 99%

Childhood Leukemia: A Preventable Disease

et al. 2016

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In contrast to most pediatric cancers, there is a growing body of literature, nationally and internationally, that has implicated the role of several environmental indoor and outdoor hazards in the etiology of childhood leukemia. For example, exposures to solvents, traffic, pesticides, and tobacco smoke have consistently demonstrated positive associations with the risk of developing childhood leukemia. Intake of vitamins and folate supplementation during the preconception period or pregnancy has been demonstrated to have a protective effect. Despite the strength of these findings, the dissemination of this knowledge to clinicians has been limited. Some children may be more vulnerable than others as documented by the high and increasing incidence of childhood leukemia in Hispanics. To protect children’s health, it is prudent to establish programs to alter exposure to those factors with well-established associations with leukemia risk rather than to suspend judgment until no uncertainty remains. This is particularly true because other serious health outcomes (both negative and positive) have been associated with the same exposures. We draw from historical examples to put in perspective the arguments of association versus causation, as well as to discuss benefits versus risks of immediate and long-term preventive actions.

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Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: Findings from the childhood leukemia international consortium

Cited by 93 publications

References 37 publications

In Utero Pesticides Exposure and Generation of Acute Myeloid Leukemia Associated Translocation (8; 21)

In Utero Pesticides Exposure and Generation of Acute Myeloid Leukemia Associated Translocation (8; 21)

Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

Childhood Leukemia: A Preventable Disease

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