Parental overcontrol x OPRM1 genotype interaction predicts school-aged children’s sympathetic nervous system activation in response to performance challenge

Partington, Lindsey C.; Borelli, Jessica L.; Smiley, Patricia A.; Jarvik, Ella R.; Rasmussen, Hannah F.; Seaman, Lauren C.; Nurmi, Erika L.

doi:10.1016/j.ridd.2018.04.011

Cited by 10 publications

(7 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In one study, for example, researchers focused on the interaction between parental overcontrol and the child’s OPRM1 genotype. The study showed that children with the G allele exhibited more sympathetic nervous system reactivity to the stress of maternal overcontrol, when compared to children homozygous for the C allele ( Partington et al, 2018 ). These results highlight the significance of OPRM1 genotype on the development of a quality attachment bond between children and parents, particularly for daughters.…”

Section: Discussionmentioning

confidence: 96%

“…In both human and non-human primates, mothers vary in contact seeking with their infants, and studies suggest that inter-individual differences in the response of the opioid system is related to differences in maternal care ( Barr et al, 2008 ; Partington et al, 2018 ). This variation in maternal behavior is in part due to the degree of response of the opioid system, which is, in part, regulated by differences in the μ-opioid receptor (OPRM1) genotype ( Bond et al, 1998 ; Lee et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Variation in the Mu-Opioid Receptor (OPRM1) and Offspring Sex Are Associated With Maternal Behavior in Rhesus Macaques (Macaca mulatta)

Wood

Baron

Schwandt

et al. 2022

Front. Behav. Neurosci.

View full text Add to dashboard Cite

A μ-opioid receptor (OPRM1) single-nucleotide-polymorphism, found in both humans and rhesus macaques mediates the mother-infant attachment bond. Because mothers treat their sons and daughters differently, it is somewhat surprising that the role of infant sex has not been assessed in the context of a maternal-OPRM1-genotype-by-infant-sex interaction. The present study investigates the effect of maternal-OPRM1-genotype and infant sex on mother-infant behaviors. Over the first 6 months of offspring life, mother-infant behavioral data assessing attachment quality was collected twice weekly from a large number of rhesus monkey mother-infant pairs (N = 161 dyads; n = 64 female infants, n = 97 male infants). Mothers were genotyped for OPRM1 variation. Factor analysis of the observed behaviors showed two factors: Attachment (maternal-infant cradling, rejections, and infant approaches and leaves), and Maternal Restraints (mother restrains infant, preventing exploration). Further analyses showed a two-way, maternal-genotype-by-infant-sex interaction for both factors. For Attachment, mothers with the CC genotype cradled and restrained (Maternal Restraints) their female infants more and rejected them less, when compared to female infants of CG mothers. Perhaps as a consequence, female infants of CC genotype mothers approached and left their mothers less often, when compared to female infants of CG mothers, likely an indication that female infants from mothers with CG genotype play a greater role in maintaining the mother-infant bond than do female infants from CC genotype mothers. This finding may also indicate a more secure attachment in infants from CC genotype mothers. Unlike female infants, on average, the mother-infant relationship of dyads with a male infant was largely undifferentiated by maternal genotype. These findings suggest that, in contrast to female infants from CG mothers, CC mothers and their female infants appear to have a closer mother-infant relationship which may portend close life-long bonds, as mothers and female offspring remain together throughout life. Male offspring appear to have a more aloof mother-infant bond regardless of OPRM1-genotype. The results of this study indicate that maternal-OPRM1 variation mediates mother-infant attachment behaviors for female infants and has less effect for male infants. This suggests that offspring sex should be included in studies investigating the effect of maternal-OPRM1 genotype on the mother-infant attachment relationship.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Variation in the Mu-Opioid Receptor (OPRM1) and Offspring Sex Are Associated With Maternal Behavior in Rhesus Macaques (Macaca mulatta)

Wood

Baron

Schwandt

et al. 2022

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…In analyses in which we predicted RSA following the task (i.e., recovery levels of RSA), we controlled for the final minute of child reactivity RSA levels on the initial step of the regression in order to measure the degree to which RSA decreased post-frustration (Linden et.al, 1997). When testing mothers' PA responsiveness to children as a predictor of children's RSA during recovery, due to our interest in modeling change from reactivity to recovery, we controlled for their RSA during the final minute of the frustration task due to its proximity in relation to the recovery period, similar to the methodology employed in prior work exploring changes within stressor-levels of physiology or from stressor-levels of physiology to recovery (Borelli et al, 2015(Borelli et al, , 2018Partington et al, 2018). It is important to note that ERN findings in the anxiety and externalizing literatures have not been entirely consistent, such that symptom/disorder and ERN patterns do not always demonstrate the expected directional relationships, particularly when there is comorbid psychopathology.…”

Section: Data Analytic Planmentioning

confidence: 99%

Maternal expressions of positive emotion for children predicts children’s respiratory sinus arrhythmia surrounding stress

Delgadillo

Boparai

Pressman

et al. 2021

Developmental Psychobiology

Self Cite

View full text Add to dashboard Cite

The aim of this study is to assess whether positive emotional exchanges (i.e., emotion coregulation) within the mother–child dyad play a protective role in children's physiological response to a distressing task. Specifically, we test whether positive emotion coregulation among mothers and their preschool‐aged children is associated with children's respiratory sinus arrhythmia (RSA) at baseline, during, and following a frustration task. One hundred Singaporean mother–child dyads (Mchildage = 3.5 years) participated in a standardized “Laughing Task” in which positive emotional constructs were measured. Children also participated in a frustration task while RSA was continuously monitored. Hierarchical linear regressions revealed that greater maternal positive emotional responses to children were associated with child RSA at baseline and in recovery from frustration, but not during frustration. These findings have implications for the important role that positive emotion responsivity from mothers may play in children's developing autonomic response systems, and underscore the need for longitudinal work on this topic.

show abstract

“…Endogenous opioid systems have been implicated in a wide variety of physiological and pathophysiological actions ( 16 ). Partington et al ( 17 ) reported that endogenous opioids are involved in neurocognitive processing of social pain and reward, and OPRM1 SNP minor allele carriers are known to be sensitive to the negative effects of social stress ( 18 ). Increased methylation of OPRM1 is associated with Alzheimer's disease, opioid exposure, alcohol and drug addiction, etc.…”

Section: Introductionmentioning

confidence: 99%

Diet, Sports, and Psychological Stress as Modulators of Breast Cancer Risk: Focus on OPRM1 Methylation

Qin

et al. 2021

Front. Nutr.

View full text Add to dashboard Cite

Background: DNA methylation is influenced by environmental factors and contributes to adverse modification of cancer risk and clinicopathological features.Methods: A case-control study (402 newly diagnosed cases, 470 controls) was conducted to evaluate the effect of environmental factors and OPRM1 methylation in peripheral blood leukocyte (PBL) DNA on the risk of breast cancer. A case-only study (373 cases) was designed to evaluate the effects of environmental factors on OPRM1 methylation in tumor tissue and the relationship of methylation with clinicopathological features.Results: We found a significant association between hypermethylation of OPRM1 and the risk of breast cancer (OR = 1.914, 95%CI = 1.357–2.777). OPRM1 hypermethylation in PBL DNA combined with low intake of vegetable, garlic, soybean, poultry, and milk; high pork intake; less regular sports and a high psychological stress index significantly increased the risk of breast cancer. Soybean intake (OR = 0.425, 95%CI: 0.231–0.781) and regular sports (OR = 0.624, 95%CI: 0.399–0.976) were associated with OPRM1 hypermethylation in tumor DNA. OPRM1 hypermethylation in tumor tissue was correlated with estrogen receptor (ER) (OR = 1.945, 95%CI: 1.262–2.996) and progesterone receptor (PR) (OR = 1.611, 95%CI: 1.069–2.427) negative status; in addition, OPRM1 hypermethylation in PBL DNA was associated with human epidermal growth factor receptor 2 (HER-2) negative status (OR = 3.673, 95%CI: 1.411–9.564).Conclusion: A healthy diet, psychosocial adaptability, and regular sports are very beneficial for breast cancer prevention and progress, especially for OPRM1 hypermethylation carriers. Personalized treatment considering the correlation between OPRM1 hypermethylation and ER and PR status may provide a novel benefit for breast cancer patients.

show abstract

Parental overcontrol x OPRM1 genotype interaction predicts school-aged children’s sympathetic nervous system activation in response to performance challenge

Cited by 10 publications

References 63 publications

Variation in the Mu-Opioid Receptor (OPRM1) and Offspring Sex Are Associated With Maternal Behavior in Rhesus Macaques (Macaca mulatta)

Variation in the Mu-Opioid Receptor (OPRM1) and Offspring Sex Are Associated With Maternal Behavior in Rhesus Macaques (Macaca mulatta)

Maternal expressions of positive emotion for children predicts children’s respiratory sinus arrhythmia surrounding stress

Diet, Sports, and Psychological Stress as Modulators of Breast Cancer Risk: Focus on OPRM1 Methylation

Contact Info

Product

Resources

About