Parental perceptions and attitudes about informed consent in clinical research involving children

Harth, S. C.; Thong, Y.H.

doi:10.1016/0277-9536(95)00058-f

Cited by 121 publications

(87 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This suggests that many parents have considerable trust in their physicians, and would depend on the physician to act with the infant's best interests in mind, which is consistent with previous studies 18 and underscores the vulnerability of parents to physician beliefs.…”

Section: Discussionsupporting

confidence: 84%

“…A very interesting finding in this study was that almost a third of both parent groups would consent to enroll their infant in a study 18 that a large percentage of parents volunteering their infant for a clinical trial did not understand that there were risks associated with participation. It has also been found that parents consenting for their infants participation were found to be more emotionally and socially disadvantaged than parents refusing consent.…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

Parents' Perceptions of Research With Newborns

et al. 2002

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 90%

Parents' Perceptions of Research With Newborns

et al. 2002

View full text Add to dashboard Cite

“…31,32,55,65 However, the relationship between anxiety, vulnerability and trial decisions may be mediated or moderated by factors such as trust in medical research 66 and the parent-practitioner relationship. 23,56,[67][68][69][70] The practicalities of trial participation are less commonly mentioned; 71 this may reflect the fact that most studies have been conducted in neonatology and oncology, when the child is usually in hospital at the time of the trial approach.…”

Section: Influences On Parents' Decision To Enter Their Child Into a mentioning

confidence: 99%

Processes in recruitment to randomised controlled trials of medicines for children (RECRUIT): a qualitative study

Shilling

Williamson²,

Hickey³

et al. 2011

Health Technol Assess

View full text Add to dashboard Cite

How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTAProcesses in recruitment to randomised controlled trials of medicines for children (RECRUIT): a qualitative study NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is n...

show abstract

“…24 In another study of parents consenting to a randomized trial on behalf of their children, neither the need to assess safety as well as ef®cacy, or the right to withdraw from the study were widely appreciated and many parents expressed the opinion that informed consent was unnecessary, as they would trust the advice of the doctor. 25 There has been little research amongst adults considering trial participation themselves, examining understanding of the manner in which randomized trials are conducted, or the impact of patients' attitudes towards randomized trials on willingness to participate. These issues are important in order to improve doctor-patient communication about clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Attitudes to randomized clinical trials amongst out‐patients attending a medical oncology clinic

Ellis

Dowsett

Butow

et al. 1999

Health Expectations

View full text Add to dashboard Cite

Objective To assess the understanding of and attitudes towards randomized clinical trials amongst patients attending oncology outpatient clinics.Design Cross-sectional survey.Subjects Patients attending medical oncology out-patient clinics at a Sydney teaching hospital.Main outcome Patients' willingness to participate in a randomized clinical trial.Results Sixty consecutive patients were surveyed. The mean age was 55.2 (SD 14) years. Eighty-eight per cent of respondents thought that patients should be asked to participate in trials testing new treatments, however, only a third would consider participating in a randomized trial themselves. If a trial was endorsed by an independent cancer information service such as the NSW Cancer Council, 72% of respondents would be more likely to participate. Knowledge about randomized trials was not high. Respondents scored a median of 3 out of 7 (interquartile range, 2±4) correct answers to a series of questions about randomized trials. Patients willing to participate in a randomized trial were more likely to perceive the doctor favourably (P 0.05), less likely to perceive trials as experimental (P 0.05) and less likely to perceive trials as representing an inconvenience or loss of control (P 0.09).Conclusions Understanding amongst patients of the need for and mechanisms of randomized clinical trials is not good. This may contribute to the di culties investigators face in seeking consent for clinical trials. Evaluation of new strategies to educate the public and patients about randomized trials is needed. Involvement of consumers in the design and conduct of clinical trials and evaluation of strategies to improve doctors' communication of clinical trial information is also required.

show abstract

Parental perceptions and attitudes about informed consent in clinical research involving children

Cited by 121 publications

References 37 publications

Parents' Perceptions of Research With Newborns

Parents' Perceptions of Research With Newborns

Processes in recruitment to randomised controlled trials of medicines for children (RECRUIT): a qualitative study

Attitudes to randomized clinical trials amongst out‐patients attending a medical oncology clinic

Contact Info

Product

Resources

About