Parental stress and food allergy phenotypes in young children: A National Birth Cohort (<scp>JECS</scp>)

Yamamoto‐Hanada, Kiwako; Pak, Kyongsun; Iwamoto, Shintaro; Konishi, Mizuho; Saito‐Abe, Mayako; Sato, Miori; Miyaji, Yumiko; Mezawa, Hidetoshi; Nishizato, Minaho; Yang, Limin; Kumasaka, Natsuhiko; Ohya, Yukihiro; ,

doi:10.1111/all.16035

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…This is the first step in implementing early nut introduction in Asian infants. We will publish the results using national big data [ 30 , 31 ] in the future. The number of participants assessed for sensitization was very small.…”

Section: Discussionmentioning

confidence: 99%

Feasibility and Safety of the Early Introduction of Allergenic Foods in Asian Infants with Eczema

Harama,

Saito-Abe,

Hamaguchi

et al. 2024

Nutrients

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Background: There is a lack of data regarding the early introduction of the consumption of allergenic food among Asian infants. Methods: We examined infants who had early-onset eczema before 6 months of age and received instructions from certified allergists for the early introduction of hen’s eggs, milk, wheat, peanuts, and tree nuts. Results: The consumption rates of hen’s eggs were 100% at 24 months. For peanuts and walnuts, the consumption rate was moderate at 12 months (48.5% and 30.3%, respectively), but by 24 months, it had progressed to 78.8% and 81.3%, respectively. In contrast, cashews remained at lower levels than other allergens at 20.7% at 12 months and 41.4% at 24 months. No adverse events related to early introductions occurred. Conclusions: In infants with eczema, allergenic foods could be introduced early and well tolerated in Asian infants. However, having eczema may indicate a predisposition to food allergies, so caution is necessary when introducing allergenic foods. The early introduction of peanuts and tree nuts was still more challenging in real-world practice in Asia as well as in Western countries.

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Section: Discussionmentioning

confidence: 99%

Feasibility and Safety of the Early Introduction of Allergenic Foods in Asian Infants with Eczema

Harama,

Saito-Abe,

Hamaguchi

et al. 2024

Nutrients

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Management of Infant Atopic Eczema to Prevent Severe Eczema and Food Allergy

Yamamoto‐Hanada,

Ohya

2024

Clin Experimental Allergy

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Early intervention and active management of infant atopic eczema may play a crucial role in limiting eczema severity and preventing the onset of immediate‐type food allergy. Eczema management involves education, skincare and medications targeting skin inflammation and barrier repair. Topical corticosteroids are the mainstay of anti‐inflammatory therapy, with nonsteroidal options available for some infants. Proactive therapy, addressing subclinical inflammation, is useful for preventing eczema flares, especially in infants with recurrent eczema flares despite reactive therapy. In clinical practice, holistic consideration of overall infant and family health is essential. Providing advice on maternal stress management, nutritional guidance and recommendations for proper sleep and lifestyle is crucial for the well‐being of children and their families, not limited to eczema treatment alone.

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Safety of Oral Food Challenges for Individuals with Low Levels of Cow’s Milk-Specific Immunoglobulin E Antibodies

Yoshida,

Kido,

Ogata

et al. 2024

Int Arch Allergy Immunol

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Introduction: Cow’s milk (CM) is one of the most common food allergens in Japan. The oral food challenge (OFC) of CM is important for the definite diagnosis of children with CM allergy and it is recommended to be actively and safely performed in individuals with low CM-sIgE levels. This study aimed to investigate the safety of low-dose CM-OFC in individuals with low CM-sIgE levels and discuss the prognostic factors and appropriate approaches for assessing the starting doses of CM-OFC in these individuals. Methods: We retrospectively analyzed 6,929 OFC tests conducted between January 1, 2017 and December 31, 2021; of which, 1,390 were CM-OFC tests. The characteristics, OFC-positive rates, CM loading, and related factors were analyzed in 138 cases involving low CM-sIgE levels. Stepwise OFC tests were conducted according to the FA guidelines in Japan using an open and unblinded method. Results: Among 138 individuals with low CM-sIgE levels, 110 (79.7%) passed the OFC test without any symptoms. Among the cases with OFC-positive status, 50.0% (14/28) cases showed symptoms with low-dose OFC (30–105 mg CM protein). Moreover, complete CM elimination was associated with a significantly high OFC-positive rate, and 60.0% (12/20) of the cases involving complete CM elimination showed symptoms with low-dose OFC. Conclusion: Eighty percent of the patients with low CM-sIgE levels safely completed the OFC test. Nevertheless, careful observation is essential during low-dose OFC test in cases with low CM-sIgE levels, especially in the cases with complete elimination. The starting dose of the OFC test should be re-evaluated and modified using baked milk or a lower dose of CM to ensure safety and early outgrowth of CM allergy.

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Parental stress and food allergy phenotypes in young children: A National Birth Cohort (JECS)

Cited by 4 publications

References 35 publications

Feasibility and Safety of the Early Introduction of Allergenic Foods in Asian Infants with Eczema

Feasibility and Safety of the Early Introduction of Allergenic Foods in Asian Infants with Eczema

Management of Infant Atopic Eczema to Prevent Severe Eczema and Food Allergy

Safety of Oral Food Challenges for Individuals with Low Levels of Cow’s Milk-Specific Immunoglobulin E Antibodies

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