Parental support and cytokine activity in childhood asthma: The role of glucocorticoid sensitivity

Miller, Gregory E.; Gaudin, Alexandra; Zysk, Eva; Chen, Eric

doi:10.1016/j.jaci.2008.12.019

Cited by 79 publications

(77 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6,31 High chronic home life stress was discovered to be associated with higher afternoon cortisol levels and a flattened cortisol rhythm throughout the day in healthy children, but no differences were found in children with asthma. 32 A blunted HPA axis response in children with asthma may be the outcome of diminished steroid receptor sensitivity subsequent to chronic stress, as proposed in a recent editorial and supported by Miller et al 33,34 In the cross-sectional analyses by Miller et al, 33 the blood cells of preadolescents with asthma who perceived low parental support (ie, had greater stress) had lower cytokine expression (IL-5 and IFN-g) and activation of eosinophils in response to the administration of a corticosteroid than children reporting higher parental support. These in vitro effects were not evident in healthy control children.…”

Section: Discussionmentioning

confidence: 92%

Lower cortisol levels in children with asthma exposed to recurrent maternal distress from birth

Dreger¹,

Kozyrskyj²,

HayGlass³

et al. 2010

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 92%

Lower cortisol levels in children with asthma exposed to recurrent maternal distress from birth

Dreger¹,

Kozyrskyj²,

HayGlass³

et al. 2010

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

“…Miller et al 78 reported that strained parent-child relations, and perhaps stress more generally, could bring about adverse outcomes in asthma by reducing cortisol's ability to regulate cytokine activity and subsequent airway inflammation. Wright,79 in an accompanying editorial, indicated that it will be important to begin to understand factors related to developmental programming of glucocorticoid sensitivity during critical periods of development, which could play a role in the cause of inflammatory respiratory disorders, as well as subsequent morbidity.…”

Section: Drug-response Modifiersmentioning

confidence: 99%

Advances in pediatric asthma in 2009: Gaining control of childhood asthma

Szefler

2010

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

“…Diminished production of antiinflammatory IL-5 and IFN-g from peripheral blood mononuclear cells, and an increase in eosinophils (18), has been reported from children with asthma who perceived low parental support (a proxy for psychosocial stress). Because psychosocial stress can provide a milieu that can augment the effect of inflammatory and oxidative stressors present in TRP (19)(20)(21), we hypothesized that children exposed to high level of chronic stress would be more susceptible to the detrimental effect of TRP on lung function deficits in children.…”

mentioning

confidence: 98%

Parental Stress Increases the Detrimental Effect of Traffic Exposure on Children's Lung Function

Islam¹,

Urman²,

Gauderman³

et al. 2011

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Rationale: Emerging evidence indicates that psychosocial stress enhances the effect of traffic exposure on the development of asthma. Objectives: We hypothesized that psychosocial stress would also modify the effect of traffic exposure on lung function deficits. Methods: We studied 1,399 participants in the Southern California Children's Health Study undergoing lung function testing (mean age, 11.2 yr). We used hierarchical mixed models to assess the joint effect of traffic-related air pollution and stress on lung function. Measurements and Main Results: Psychosocial stress in each child's household was assessed based on parental response to the perceived stress scale (range, 0-16) at study entry. Exposures to nitric oxide, nitrogen dioxide, and total oxides of nitrogen (NO x ), surrogates of the traffic-related pollution mixture, were estimated at schools and residences based on a land-use regression model. Among children from high-stress households (parental perceived stress scale .4) deficits in FEV 1 of 4.5 (95% confidence interval, 26.5 to 22.4) and of 2.8% (25.7 to 0.3) were associated with each 21.8 ppb increase in NO x at homes and schools, respectively. These pollutant effects were significantly larger in the high-stress compared with lower-stress households (interaction P value 0.007 and 0.05 for residential and school NOx, respectively). No significant NOx effects were observed in children from low-stress households. A similar pattern of association was observed for FVC. The observed associations for FEV 1 and FVC remained after adjusting for sociodemographic factors and after restricting the analysis to children who do not have asthma. Conclusions: A high-stress home environment is associated with increased susceptibility to lung function effects of air pollution both at home and at school.

show abstract

Parental support and cytokine activity in childhood asthma: The role of glucocorticoid sensitivity

Cited by 79 publications

References 45 publications

Lower cortisol levels in children with asthma exposed to recurrent maternal distress from birth

Lower cortisol levels in children with asthma exposed to recurrent maternal distress from birth

Advances in pediatric asthma in 2009: Gaining control of childhood asthma

Parental Stress Increases the Detrimental Effect of Traffic Exposure on Children's Lung Function

Contact Info

Product

Resources

About