Parenteral iron administration in suckling piglets – a review

Svoboda, Martin; Vaňhara, Jonáš; Berlinská, Jana

doi:10.2754/avb201786030249

Cited by 25 publications

(33 citation statements)

References 49 publications

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“…The problem of neonatal IDA in piglets was first comprehensively drawn to the attention of the scientific community by Venn et al in 1947 [3]. Thereafter, various aspects of IDA in piglets such as etiology, clinical aspects, diagnosis, prophylaxis and treatment have been the subject of several reviews [3,4,5,9,10,11].…”

Section: Iron Deficiency Anemia (Ida) In Suckling Pigletsmentioning

confidence: 99%

“…However, it is worth noting that physiological reference ranges for RBC indices of piglets in the early postnatal period (from birth to weaning, i.e., usually up to day 28 postpartum) commonly used to diagnose IDA are difficult to estimate. In swine production, iron supplementation of piglets is a routine and mandatory practice performed with the use of various iron supplements, administered by various routes, at differential doses of supplemental iron, and following various time schedules (reviewed in [9,10]). It is not surprising therefore that RBC parameters strongly vary in piglets depending on iron treatment protocols.…”

Section: Iron Deficiency Anemia (Ida) In Suckling Pigletsmentioning

confidence: 99%

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Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia

et al. 2018

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In pigs, iron deficiency anemia (IDA) is the most prevalent deficiency disorder during the early postnatal period, frequently developing into a serious illness. On the other hand, in humans, only low-birth-weight infants, including premature infants, are especially susceptible to developing IDA. In both human and pig neonates, the initial cause of IDA is low birth iron stores. In piglets this shortage of stored iron results mainly from genetic selection over the past few decades for large litter sizes and high birth weights. As a consequence, pregnant sows cannot provide a sufficient amount of iron to the increasing number of developing fetuses. Supplementation with iron is a common practice for the treatment of IDA in piglets. For decades, the preferred procedure for delivering iron supplements during early life stages has been through the intramuscular injection of a large amount of iron dextran. However, this relatively simple therapy, which in general, efficiently corrects IDA, may generate toxic effects, and by inducing hepcidin expression, may decrease bioavailability of supplemental iron. New iron supplements are considered herein with the aim to combine the improvement of hematological status, blunting of hepcidin expression, and minimizing the toxicity of the administered iron. We propose that iron-deficient piglets constitute a convenient animal model for performing pre-clinical studies with iron supplements.

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Section: Iron Deficiency Anemia (Ida) In Suckling Pigletsmentioning

confidence: 99%

Section: Iron Deficiency Anemia (Ida) In Suckling Pigletsmentioning

confidence: 99%

Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia

et al. 2018

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“…For example, the use of dried distiller grains in feed may be more prominent recently, as this byproduct of ethanol production is now more accessible. There may also be nonfeed introductions of trace elements, for nutrition (e.g., injection of Fe, Svoboda et al, 2017) or for other health and barn management reasons. Of the potentially toxic elements that are not or rarely added as supplements, B, Cd, Co, Ni, and Pb all significantly decreased, and although these elements would rarely have become problematic in soils, a downward change is preemptive to limit accumulation in soil.…”

Section: Resultsmentioning

confidence: 99%

Elemental Composition of Swine Manure from 1997 to 2017: Changes Relevant to Environmental Consequences

Sheppard¹

2019

J of Env Quality

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There have been revisions in the composition of swine diets in the last two decades that not only improved production profitability but also had potential environmental benefits. Among other changes, the use of phytase in feed has enabled lower total P concentrations. Nitrogen, specifically protein, concentrations are expected to be lower, and certain trace elements were also expected to change. In this study, analyses of 1195 swine slurry manure samples from various barn types in Manitoba, Canada, collected from 1997 to 2002 were compared with similar analyses from 2010 and 2017. Concentrations of P were significantly lower in 2017, from a median in sow barns of 28.0 g kg−1 dry weight (dw) in 1998 to 2002 to 20.6 g kg−1 dw in 2010 and 2017, and from a median in feeder finisher barns of 24.1 g kg−1 dw in 1998 to 2002 to 18.7 g kg−1 dw in 2010 and 2017. Total N levels did not change with time, but the fraction of manure N that was NH4 decreased. Zinc concentrations were consistently higher in nursery manures than in other swine manures and increased from a median of 2800 mg kg−1 dw in nursery barns in 1998 to 2002 to 5580 mg kg−1 dw in nursery barns in 2010 and 2017. Concentrations of most other trace elements decreased over this time period. With the exception of Zn from nursery barns, these temporal changes should lessen the potential for environmental consequences from swine manure application to land. Core Ideas Hog manure has the potential to supply excess nutrients and trace elements to soils. Feed practices have changed and concentrations of some elements may now be lower. Manure samples (n = 1195) from production operations were analyzed over 20 yr. Phosphorus concentration decreased up to 36%, concurrent with introduction of phytase. Most trace elements also decreased, but Zn doubled in nursery manure over 20 yr.

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“…Thereafter, various aspects of IDA in piglets such as etiology, clinical aspects, diagnosis, prophylaxis and treatment have been the subject of a couple of reviews [3][4][5][9][10][11].…”

Section: Iron Deficiency Anemia (Ida) In Suckling Pigletsmentioning

confidence: 99%

“…usually up to day 28 postpartum) commonly used to diagnose IDA are difficult to estimate. In swine production iron supplementation of piglets is a routine and mandatory practice performed with the use of various iron supplements, administered by various routes, at differential doses of supplemental iron, and following various time schedules [reviewed in 9,10]. It is not surprising therefore that RBC parameters strongly vary in piglets depending on iron treatment protocols.…”

Section: Iron Deficiency Anemia (Ida) In Suckling Pigletsmentioning

confidence: 99%

Iron Supplementation in Suckling Piglets: an Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia

Szudzik

Starzyński

Jończy

et al. 2018

Preprint

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In pigs, iron deficiency anemia (IDA) is the most prevalent deficiency disorder during the early postnatal period frequently developing into a critical illness. Meanwhile, in humans, only low-birth-weight infants, including premature infants are especially susceptible to developing IDA. In both human and pig neonates, the initial cause of IDA is low birth iron stores. In piglets this shortage of stored iron results mainly from genetic selection over the past few decades for large litter size and high birth weight. In consequence, pregnant sows cannot provide sufficient amount of iron to the increasing number of developing fetuses. Supplementation with iron is a common practice for the treatment of IDA in piglets. For decades, the preferred procedure for delivering iron supplements during early life stages has been through the intramuscular injection of large amount of iron dextran. However, this relatively simple therapy, which in general, efficiently corrects IDA, may generate toxic effects, and by inducing hepcidin expression, may decrease bioavailability of supplemental iron. New iron supplements are considered now with the aim to combine improvement of hematological status, blunting hepcidin expression, and minimizing toxicity of the administered iron. We propose that iron-deficient piglets constitute a convenient animal model for performing pre-clinical studies with iron supplements.

show abstract

Parenteral iron administration in suckling piglets – a review

Cited by 25 publications

References 49 publications

Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia

Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia

Elemental Composition of Swine Manure from 1997 to 2017: Changes Relevant to Environmental Consequences

Iron Supplementation in Suckling Piglets: an Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia

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