Parenteral nutrition-associated liver disease and lipid emulsions

Murillo, Ana Zugasti; Jáuregui, Estrella Petrina; Armendáriz, Javier Elizondo

doi:10.1016/j.endoen.2015.06.005

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…It is well established that parenteral nutrition results in deterioration of liver function, potentially leading to parenteral nutrition–associated liver disease (PNALD) 23‐25 . Liver grafts require time to stabilize and establish normal functioning, and LT recipients are exposed to the hazards of unnecessary parenteral nutrition during this period 26 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of Measured Energy Expenditure Using Indirect Calorimetry vs Predictive Equations for Liver Transplant Recipients

Lee

Jung

et al. 2020

J Parenter Enteral Nutr

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Background: To assess the appropriate energy expenditure requirement for liver transplant (LT) recipients in South Korea, 4 commonly used predictive equations were compared with indirect calorimetry (IC). Methods: A prospective observational study was conducted in the surgical intensive care unit (ICU) of an academic tertiary hospital between December 2017 and September 2018. The study population comprised LT recipients expected to remain in the ICU >48 hours postoperatively. Resting energy expenditure (REE) was measured 48 hours after ICU admission using open-circuit IC. Theoretical REE was estimated using 4 predictive equations (simple weight-based equation [25 kcal/kg/day], Harris-Benedict, Ireton-Jones [ventilated], and Penn State 1988). Derived and measured REE values were compared using an intraclass correlation coefficient (ICC) and Bland-Altman plots. Results: Of 50 patients screened, 46 were enrolled, were measured, and completed the study. The Penn State equation showed 65.0% agreement with IC (ICC, 0.65); the simple weight-based (25 kcal/kg/day), Harris-Benedict, and Ireton-Jones equations showed 62.0%, 56.0% and 39.0% agreement, respectively. Bland-Altman analysis showed that all 4 predictive equations had fixed bias, although the simple weight-based equation (25 kcal/kg/day) showed the least. Conclusion: Although predicted REE calculated using the Penn State method agreed with the measured REE, all 4 equations showed fixed bias and appeared to be inaccurate for predicting REE in LT recipients. Precise measurement using IC may be necessary when treating LT recipients to avoid underestimating or overestimating their metabolic needs.

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Section: Discussionmentioning

confidence: 99%

Comparison of Measured Energy Expenditure Using Indirect Calorimetry vs Predictive Equations for Liver Transplant Recipients

Lee

Jung

et al. 2020

J Parenter Enteral Nutr

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“…To mitigate the risk of liver injury during TPN therapy, maintaining a lipid dosage of 1 g/kg/day and employing lipids composed of a blend of soybean oil, medium-chain triglycerides, and long-chain triglycerides may prove beneficial. 6 In TPN-dependent patients presenting with abnormal liver enzymes, TPN is often considered the initial culprit. Nevertheless, when TPN can be ruled out, a comprehensive examination of other potential causes is warranted.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Case of Abnormal Liver Function Tests in a Patient Receiving Total Parenteral Nutrition

Tran

Rim

Nolen‐Doerr

et al. 2023

Journal of Investigative Medicine High Impact Case Reports

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Hepatic dysfunction is prevalent in patients receiving total parenteral nutrition (TPN), resulting from steatosis, cholestasis, and cholecystitis. Regular assessments and monitoring of TPN patients are essential, even for clinically stable patients on long-term TPN. Furthermore, it is crucial to establish a differential diagnosis for hepatic dysfunction and investigate for other possible causes of elevated liver enzymes and underlying liver conditions. We present the case of a 56-year-old female patient with severe protein-calorie malnutrition on TPN, who exhibited significantly elevated liver enzymes during the routine periodic assessment. Subsequent investigation revealed that the patient had been taking traditional Chinese herbal medications concurrently with TPN. After discontinuing the herbal medications, the patient’s liver enzymes returned to normal levels within 3 weeks.

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The effects of two mixed intravenous lipid emulsions on clinical outcomes in infants after gastrointestinal surgery: a prospective, randomized study

et al. 2018

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Parenteral nutrition-associated liver disease and lipid emulsions

Cited by 6 publications

References 29 publications

Comparison of Measured Energy Expenditure Using Indirect Calorimetry vs Predictive Equations for Liver Transplant Recipients

Comparison of Measured Energy Expenditure Using Indirect Calorimetry vs Predictive Equations for Liver Transplant Recipients

A Case of Abnormal Liver Function Tests in a Patient Receiving Total Parenteral Nutrition

The effects of two mixed intravenous lipid emulsions on clinical outcomes in infants after gastrointestinal surgery: a prospective, randomized study

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