Parenteral nutrition practices in hospital pharmacies in Switzerland, France, and Belgium

Maisonneuve, Nadine; Raguso, Comasia A.; Paoloni-Giacobino, Ariane; Mühlebach, S.; Corriol, Odile; Saubion, J.L.; Hecq, Jean-Daniel; Bailly, A.C.; Berger, Mette M.; Pichard, Claude

doi:10.1016/j.nut.2004.03.020

Cited by 41 publications

(50 citation statements)

References 23 publications

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“…The bags used for the solutions were gas-barrier multiplayer bags (Stedim, Aubagne, France). This type of bag has the double advantage of preventing oxidation of the components [16] while also preventing the sterilizing gas (peracetic acid) from penetrating during sterilization in the isolator [17]. In addition, the prepared bags were removed sealed from the isolator via a double-interlocking door fitted with a single-use plastic container system allowing them to be packed in an impervious sterile outer pack (Tubing, La Calhène, Vendôme, France).…”

Section: Preparation Of Parenteral Admixturesmentioning

confidence: 99%

“…Furthermore, preparation of individualized solutions is limited by the pharmacy's production capacity and the possibility of quality controls for each solution prepared [17]. Preparation of standard solutions has been proposed to improve the ergonomics of the production process but needs to be validated in terms of advantages and tolerance for the neonate patient [13].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of implementation of a standardized parenteral formulation for early nutritional support of very preterm infants

et al. 2006

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Standardized parenteral formulations provided higher early intakes of amino acid and glucose, a better calcium phosphate ratio, and a greater amount of amino-acid intakes during the first week while maintaining the same biochemical parameters. This strategy forms part of an approach concerning quality control and the respect of good professional practice for the preparation of parenteral nutrition solutions.

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Section: Preparation Of Parenteral Admixturesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of implementation of a standardized parenteral formulation for early nutritional support of very preterm infants

et al. 2006

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“…The manufacturers of amino acid, dextrose, lipid, and salt additives used in TPN solutions need to carefully monitor, and reduce as necessary, its Cr concentrations to avoid an increase in the body's burden of Cr, even during short-term parenteral infusion. [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

On-line preconcentration and determination of chromium in parenteral solutions by inductively coupled plasma optical emission spectrometry

Gil

Cerutti

Gásquez

et al. 2005

Spectrochimica Acta Part B: Atomic Spectroscopy

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“…Similar results were obtained by European and Swiss surveys conducted from the late 1990s to early 2000s. 12,13 Nevertheless, standardized PN is gaining in popularity. Some recently published studies demonstrated the feasibility of using standardized, even commercial PN in pediatrics and neonatology, although no clear advantage has been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Automated Compounding of Parenteral Nutrition for Pediatric Patients: Characterization of Workload and Costs

Raimbault

Thibault

Lebel

et al. 2012

The Journal of Pediatric Pharmacology and Therapeutics

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OBJECTIVES Parenteral nutrition (PN) compounding in large hospital centers is now largely automated using volumetric pump systems. No study has examined the pharmacy workload and costs associated with this process. This study was designed to characterize these elements at our center and to identify areas for potential improvement. METHODS We retrospectively analyzed all PN orders compounded from May 19, 2007, to June 25, 2010. Patients were divided into groups according to the ward where PN was initiated. RESULTS The age and weight of patients at initiation of PN were similar throughout the study, except in neonatology, where initiation now occurs earlier in life (age 1.3 ± 2.7 days in 2010 vs. 3.4 ± 9.4 in 2007; p=0.003). An average of 894 orders per month were compounded. A total of 59% of orders were for neonatal patients. The average cost of source solutions per PN order increased from Can$23.27 in 2007 to Can$37.78 in 2010. Partially used source solutions discarded at the end of the day represented between 7.7% and 9.2% of total source solution cost. Amino acids in 3-L bags were responsible for the largest waste, with Can$953 to Can$1048 wasted monthly. CONCLUSIONS PN compounding at our center represents an important workload and increasing costs. A reduction in source solution waste, for example, by reducing the use of large source solution containers, would be beneficial.

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Parenteral nutrition practices in hospital pharmacies in Switzerland, France, and Belgium

Cited by 41 publications

References 23 publications

Assessment of implementation of a standardized parenteral formulation for early nutritional support of very preterm infants

Assessment of implementation of a standardized parenteral formulation for early nutritional support of very preterm infants

On-line preconcentration and determination of chromium in parenteral solutions by inductively coupled plasma optical emission spectrometry

Automated Compounding of Parenteral Nutrition for Pediatric Patients: Characterization of Workload and Costs

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