Parenteral Products

Boylan, James C.; Nail, Steven L.

doi:10.1201/9780824744694.ch12

Cited by 6 publications

(11 citation statements)

References 7 publications

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“…The syringeability test was performed using a 19‐gauge syringe needle, which is acceptable for intramuscular injection (19–22 gauge) [45] . Constant pressure was applied (70 mmHg).…”

Section: Resultsmentioning

confidence: 99%

“…It is worth noting that the subcutaneously injected lipospheres showed slower in‐vivo release when compared with the intramuscularly injected formula. This might be due to the presence of fat layer in the subcutaneous tissue, which hinders the release of the polar drug, in addition to the lower extent of blood flow in this tissue when compared with the highly perfused muscles [45] …”

Section: Resultsmentioning

confidence: 99%

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Biodegradable donepezil lipospheres for depot injection: optimization and in-vivo evaluation

Yehia

Elshafeey

Elsayed

2012

Journal of Pharmacy and Pharmacology

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“…The syringeability test was performed using a 19‐gauge syringe needle, which is acceptable for intramuscular injection (19–22 gauge) [45] . Constant pressure was applied (70 mmHg).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Biodegradable donepezil lipospheres for depot injection: optimization and in-vivo evaluation

Yehia

Elshafeey

Elsayed

2012

Journal of Pharmacy and Pharmacology

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“…Through parenteral route, drugs are administered by injection under or through one or more layers of skin or mucous membrane into body tissues and many times directly into blood. 1 Parenteral medications are a vital component of the modern therapeutic armamentarium. They offer a number of advantages over other dosage forms.…”

Section: Introductionmentioning

confidence: 99%

Formulation, development and evaluation of injectable formulation of Aspirin

Patel

Modi

et al. 2013

Drugs Ther Studies

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The objective of this study was to develop and manufacture a stable parenteral formulation for Aspirin, a non steroidal anti-inflammatory agent. The solubility and stability of the drug was determined. Solubility studies suggested that Aspirin exhibited poor aqueous solubility but showed appreciable solubility in non-aqueous solvents. Based on the preformulation studies, a lyophilized parenteral formulation containing 25 mg/mL of Aspirin was prepared in a solvent system containing of 80% v/v water and 20% v/v polyethylene glycol-400 (PEG-400). Rubber closures, filter membranes, and liquid transfer tubing were selected on the basis of compatibility studies. The formulation was subjected to accelerated stability studies. After reconstitution with sterile water for injection, Aspirin injection was stable for a period of 8 hr at 2°C to 8°C. Accelerated stability studies suggested that the lyophilized product should be kept at controlled room temperature for longterm storage. The proposed non-aqueous solvent concentration used, are known to safe hence, toxicities/safety related issues may not raise. The proposed techniques would be economical, convenient and safe. Thus, the study opens the chances of preparing lyophilized formulation of poorly-water soluble drugs.

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“…[2] However, these preparations have certain limitations such as administration problems due to high viscosity, clogging of needles, pain at the injection site, instability due to sedimentation, difficulties in maintaining uniform particle size under aseptic conditions, homogeneity, and drug content uniformity. [3] The use of subdermal implants has ensured better control over drug release with predictable release rates and is considered superior to repository injections in terms of efficacy and safety. [2] However, many of these implants are solid devices which require surgical incision for placing the device in the subcutaneous tissue, and if non-biodegradable, may require retrieval after drug release is complete by surgical intervention.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Koland¹

2017

AJP

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Introduction: Injectable in situ gelling solutions are novel implantable systems that combine the advantages of a prolonged release subdermal implant and the convenience of administration of an aqueous solution. Objectives: The aim of the present investigation was to formulate and evaluate a thermo-reversible injectable in situ gelling system of rivastigmine tartrate. Methods: Injectable in situ gelling solutions loaded with rivastigmine were formulated using the thermosensitive polymers: Pluronic F127 and Pluronic F68. The thermo-reversible gelling solutions were evaluated for gelation temperature, gel strength, syringeability and injectability, drug content, in vitro drug release studies, and ex vivo studies using extensor digitorum muscle of Gallus gallus domesticus. Results: Gelation temperature and gel strength increased with increasing concentrations of Pluronic F 68. All six formulations showed adequate ease on withdrawal and injection. The viscosity of formulations also increased with increase in the percentage of Pluronic F68 both in sol and gel form. An initial burst effect as a result of the immediate drug release from the sol form of the preparation before conversion to gel was observed from all formulations. Drug release was slower with an increase in the concentration of Pluronic F68. Ex vivo drug permeation studies for over 27 h exhibited slower release patterns from the selected formulations as compared to in vitro release. Conclusion:The developed formulations are capable of prolonging release of rivastigmine with the potential of achieving greater therapeutic success in Alzheimer patients compared to the conventional oral dosage forms.

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Parenteral Products

Cited by 6 publications

References 7 publications

Biodegradable donepezil lipospheres for depot injection: optimization and in-vivo evaluation

Biodegradable donepezil lipospheres for depot injection: optimization and in-vivo evaluation

Formulation, development and evaluation of injectable formulation of Aspirin

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