Parenteral Vaccine Administration: Tried and True

Johansen, Pål; Kündig, Thomas M.

doi:10.1007/978-1-4939-1417-3_14

Cited by 4 publications

(1 citation statement)

References 157 publications

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“…The intradermal (ID) route is another promising route of administration, as the dense vascularity and extensive lymphatic drainage of the dermis provides an ideal microenvironment for efficient Ag trafficking by APCs (31). Subcutaneous (SC) injection is also a possible means of local delivery since the loose adipose tissue of the subcutis can sustain large injection volumes, and cause less pain (32,33). Additionally, intravenous (IV) administration may also be employed to deliver the vaccine systemically, and permits the largest volume of administration compared to other routes (34).…”

Section: Mrna Vaccine Mechanism and Routes Of Administrationmentioning

confidence: 99%

The Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review

Ladak

Huang

et al. 2022

Front. Immunol.

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Both infectious viral diseases and cancer have historically been some of the most common causes of death worldwide. The COVID-19 pandemic is a decidedly relevant example of the former. Despite progress having been made over past decades, new and improved techniques are still needed to address the limitations faced by current treatment standards, with mRNA-based therapy emerging as a promising solution. Highly flexible, scalable and cost-effective, mRNA therapy is proving to be a compelling vaccine platform against viruses. Likewise, mRNA vaccines show similar promise against cancer as a platform capable of encoding multiple antigens for a diverse array of cancers, including those that are patient specific as a novel form of personalized medicine. In this review, the molecular mechanisms, biotechnological aspects, and clinical developments of mRNA vaccines against viral infections and cancer are discussed to provide an informative update on the current state of mRNA therapy research.

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Section: Mrna Vaccine Mechanism and Routes Of Administrationmentioning

confidence: 99%

The Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review

Ladak

Huang

et al. 2022

Front. Immunol.

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Formulation and Delivery Technologies for mRNA Vaccines

Zeng

Zhang

Walker

et al. 2020

Current Topics in Microbiology and Immunology

134

131

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mRNA vaccines have become a versatile technology for the prevention of infectious diseases and the treatment of cancers. In the vaccination process, mRNA formulation and delivery strategies facilitate effective expression and presentation of antigens, and immune stimulation. mRNA vaccines have been delivered in various formats: encapsulation by delivery carriers, such as lipid nanoparticles, polymers, peptides, free mRNA in solution, and ex vivo through dendritic cells. Appropriate delivery materials and formulation methods often boost the vaccine efficacy which is also influenced by the selection of a proper administration route. Co-delivery of multiple mRNAs enables synergistic effects and further enhances immunity in some cases. In this chapter, we overview the recent progress and existing challenges in the formulation and delivery technologies of mRNA vaccines with perspectives for future development.

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Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines?

Bobbala

Hook

2016

Pharm Res

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Modern vaccine design has moved away from attenuated or inactivated whole-pathogen vaccines to more pure and defined subunit vaccines. However subunit antigens have poor bioavailability and stability and lack immunogenicity. To overcome these issues subunit vaccines have to be administered in a suitable delivery system in combination with immune stimulants. Many different delivery systems have been developed and investigated each having different modes of action, for example increasing delivery and/or sustaining delivery of antigen to immune cells. In addition a number of different routes of immunization are possible and these can play a crucial role in determining the fate of an immune response. In this review the different strategies for the delivery of prophylactic and therapeutic subunit vaccines along with the impact of these on the immune responses generated are discussed.

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Parenteral Vaccine Administration: Tried and True

Cited by 4 publications

References 157 publications

The Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review

The Current Landscape of mRNA Vaccines Against Viruses and Cancer–A Mini Review

Formulation and Delivery Technologies for mRNA Vaccines

Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines?

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