Parenteral versus Oral Route Increases Paracetamol Efficacy

The Evaluation of Safety and Analgesic Efficacy of Paracetamol and Ibuprofen Followed by Impacted Third Molar Surgery

“…Prodrug of paracetamol that can be administered parenterally when greater efficacy or a fast onset of analgesia is desirable. IV infusion of propacetamol 2 g was significantly more effective than paracetamol 1 g taken orally in patients with moderate to severe postoperative pain after hallux valgus surgery (13,14). There are conflicting results concerning preemptive and preventive administration of different groups of analgesics.…”

OFIRMEV: An Old Drug Becomes New Again

“…19 IV acetaminophen has been shown to achieve higher maximum concentrations and earlier time to maximum concentration compared to bioequivalent oral doses with less intrasubject variability. 15,16,[20][21][22] Mean maximum concentration after a standard 15-minute infusion of 1 g acetaminophen is approximately 70% higher than the mean maximum concentration observed at equivalent oral doses. 22 Peak CSF plasma concentrations of IV acetaminophen are 60% higher than with oral administration.…”

Use of Intravenous Acetaminophen in the Treatment of Postoperative Pain

“…This was demonstrated in both third molar removal and major orthopedic surgery in adults and craniofacial surgery in pediatric patients, where IVadministration was associated with a faster (T max ) and higher peak serum level (C max ). [8][9][10][11] The onset of analgesia occurs within 5 to 10 minutes of IV administration, with the peak analgesic effect being obtained within 1 hour and an effective duration of 4 to 6 hours. 7 Although in clinical trials the drug was studied only as a postoperative analgesic and antipyretic, some clinicians may see a benefit to using this drug preoperatively or intraoperatively.…”