Parenteral vitamin C relieves chronic fatigue and pain in a patient with rheumatoid arthritis and mononeuritis multiplex secondary to CNS vasculitis

Carr, Anitra C.; Vissers, Margreet C.M.; Cook, John S.

doi:10.5430/crcp.v2n2p57

Cited by 6 publications

(6 citation statements)

References 21 publications

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“…But when given in the form of infusions of high-dose vitamin C in a patient with rheumatoid arthritis, it produced complete decrease in pain. [ 43 ]…”

Section: Itamin C and M mentioning

confidence: 99%

An insight and update on the analgesic properties of vitamin C

et al. 2018

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Pain is an unpleasant subjective feeling having implications on both physical and mental realm. Multiple dimensions of pain involving behavioral, spiritual, emotional, and cognitive changes have been studied and pathways elucidated. It is stressed that the nature in which pain is modulated and perceived at a higher center is a complex phenomenon. One of the main goals of pain modulation is to modify pain to a more tolerable level, rather than its complete eradication. Different pain management interventions were tried but have effects that are more adverse. Till date, the only reliable pain blockers are analgesics and anti-inflammatory drugs in the form of opioids and non-opioids. Despite this, most of the drugs are ineffective at various levels, furthermore, adding to complications. Thus, there is an urgent need for effective intervention with minimal side effects. Ascorbic acid, popularly known as vitamin C, has shown to exhibit promising analgesic properties. The literature is sparse with the usage of the drug in various forms of pain. This review focuses on the dynamics and kinetics of vitamin C and its usage in various forms of pain. With minimal adverse effects, the drug is shown to perform well in different types of pain disorders, thus paving way for alternative interventional agent for pain management.

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“…But when given in the form of infusions of high-dose vitamin C in a patient with rheumatoid arthritis, it produced complete decrease in pain. [ 43 ]…”

Section: Itamin C and M mentioning

confidence: 99%

An insight and update on the analgesic properties of vitamin C

et al. 2018

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“…Calcitonin + 3 g/day vitamin C (N = 11) for 2 weeks ii. Pain relief in 73%, marked ↓ pain in 45% Uncontrolled prospective Arthritic joint replacement surgery [ 54 ] a 500 mg/day oral vitamin C (N = 34) for 50 days 0% CRPS cases Paget’s disease of bone [ 58 ] 3 g/day oral vitamin C (N = 16) for 2 weeks ↓ Pain in 50%, no pain in 20% (within 5-7 days) Case report Rheumatoid arthritis [ 56 ] 50 g IV vitamin C twice/week for 4 weeks Before: 100% pain (QLQ) After: 0% pain IV intravenous, VAS visual analog scale, QLQ quality of life questionnaire * P < 0.05 a Study was included in CRPS meta-analysis [ 48 – 52 ] …”

Section: Introductionmentioning

confidence: 99%

“…The observed decrease in pain was less than half that reported for non-steroidal anti-inflammatories. We have shown a complete decrease in pain in a patient with rheumatoid arthritis following administration of twice weekly infusions of high-dose vitamin C [ 56 ]. This data suggests that vitamin C may be more effective for the pain associated with rheumatoid arthritis than osteoarthritis, or that intravenous administration of the vitamin may be more effective than oral administration in patients with arthritis.…”

Section: Introductionmentioning

confidence: 99%

The role of vitamin C in the treatment of pain: new insights

Carr¹,

McCall²

2017

J Transl Med

Self Cite

121

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The vitamin C deficiency disease scurvy is characterised by musculoskeletal pain and recent epidemiological evidence has indicated an association between suboptimal vitamin C status and spinal pain. Furthermore, accumulating evidence indicates that vitamin C administration can exhibit analgesic properties in some clinical conditions. The prevalence of hypovitaminosis C and vitamin C deficiency is high in various patient groups, such as surgical/trauma, infectious diseases and cancer patients. A number of recent clinical studies have shown that vitamin C administration to patients with chronic regional pain syndrome decreases their symptoms. Acute herpetic and post-herpetic neuralgia is also diminished with high dose vitamin C administration. Furthermore, cancer-related pain is decreased with high dose vitamin C, contributing to enhanced patient quality of life. A number of mechanisms have been proposed for vitamin C’s analgesic properties. Herein we propose a novel analgesic mechanism for vitamin C; as a cofactor for the biosynthesis of amidated opioid peptides. It is well established that vitamin C participates in the amidation of peptides, through acting as a cofactor for peptidyl-glycine α-amidating monooxygenase, the only enzyme known to amidate the carboxy terminal residue of neuropeptides and peptide hormones. Support for our proposed mechanism comes from studies which show a decreased requirement for opioid analgesics in surgical and cancer patients administered high dose vitamin C. Overall, vitamin C appears to be a safe and effective adjunctive therapy for acute and chronic pain relief in specific patient groups.

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“…Among the top positions in the ranking, we find drugs with known effects in rheumatoid arthritis patients or animal models of rheumatoid arthritis, and one of these went into clinical trial stage: rosiglitazone 3 , pioglitazone [Suke et al, 2013], estradiol [Romo-García et al, 2020], captopril [Martin et al, 1984], vitamin c [Carr et al, 2015], baclofen [Huang et al, 2015], deferasirox [Polson et al, 1986], decitabine [Petralia et al, 2019], sirolimus [Wen et al, 2019], hydrocortisone [Boland, 1952], paclitaxel [Kurose et al, 2001], and ethinylestradiol [Subramanian et al, 2005]. Suke et al [Suke et al, 2013] studied the effects of combined pioglitazone and prednisolone on adjuvant-induced arthritis in rats.…”

Section: Drugmerge Results On Rheumatoid Arthritis (Ra)mentioning

confidence: 99%

“…Vitamin C is a vitamin found in various foods and it is important for immune system function. It has also been studied the role of the vitamin c in treating pain [Carr and McCall, 2017], in particular, an administration of high-dose vitamin C in patients with rheumatoid arthritis showed a complete decrease in pain [Carr et al, 2015]. Baclofen is a medication used to treat muscle spasticity.…”

Section: Drugmerge Results On Rheumatoid Arthritis (Ra)mentioning

confidence: 99%

Drug Repositioning by Merging Active Subnetworks Validated in Cancer and COVID-19

Lucchetta

Pellegrini

2021

Preprint

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Computational Drug Repositioning aims at ranking and selecting existing drugs for use in novel diseases or existing diseases for which these drugs were not originally designed. Using vast amounts of available omic data in digital form within an in silico screening has the potential for speeding up considerably the shortlisting of promising candidates in response to outbreaks of diseases such as COVID-19 for which no satisfactory cure has yet been found. We describe DrugMerge as a methodology for preclinical computational drug repositioning based on merging multiple drug rankings obtained with an ensemble of Disease Active Subnetwork construction algorithms. DrugMerge uses differential transcriptomic data from cell lines/tissues of patients affected by the disease and differential transcriptomic data from drug perturbation assays, in the context of a large gene co-expression network. Experiments with four benchmark diseases (Asthma, Rheumatoid Arthritis, Prostate Cancer, and Colorectal Cancer) demonstrate that our method detects in first position drugs in clinical use for the specified disease, in all four cases. Our method is competitive with the state-of-the-art tools such as CMAP (Connectivity Map). Application of DrugMerge to COVID-19 data found rankings with many drugs currently in clinical trials for COVID-19 in top positions, thus showing that DrugMerge is able to mimic human expert judgment

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Parenteral vitamin C relieves chronic fatigue and pain in a patient with rheumatoid arthritis and mononeuritis multiplex secondary to CNS vasculitis

Cited by 6 publications

References 21 publications

An insight and update on the analgesic properties of vitamin C

An insight and update on the analgesic properties of vitamin C

The role of vitamin C in the treatment of pain: new insights

Drug Repositioning by Merging Active Subnetworks Validated in Cancer and COVID-19

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