2000
DOI: 10.1007/s001340051278
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Parenteral with enteral nutrition in the critically ill

Abstract: Although it enhances nutrient intake and corrects nutritional parameters such as RBP and prealbumin more rapidly, within 1 week, supplemental parenteral nutrition has no clinically relevant effect on outcome in ICU patients at the early phase of nutritional support.

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Cited by 147 publications
(112 citation statements)
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“…Increased mortality risk in late SPN than in EN, higher percentage of alive discharge from ICU in the late PN than in early PN, no difference in ICU and in-hospital mortality between late and early PN , prolonged or shorter hospital LOS in early PN than in late PN, as well as shorter stay in the EN group than in the PN groups and increased ICU stay but improved hospital mortality in the EN+SPN strategy than in the EN strategy were reported (9,10,(18)(19)(20)(27)(28)(29)(30).…”
Section: Discussionmentioning
confidence: 92%
“…Increased mortality risk in late SPN than in EN, higher percentage of alive discharge from ICU in the late PN than in early PN, no difference in ICU and in-hospital mortality between late and early PN , prolonged or shorter hospital LOS in early PN than in late PN, as well as shorter stay in the EN group than in the PN groups and increased ICU stay but improved hospital mortality in the EN+SPN strategy than in the EN strategy were reported (9,10,(18)(19)(20)(27)(28)(29)(30).…”
Section: Discussionmentioning
confidence: 92%
“…In a meta‐analysis of six RCTs extracted from the JSICM guidelines287 (Doig,323 Langouche,324 Heidegger,325 Casaer,326 Singer,327 and Bauer328), all six reported on mortality rate, four reported on bloodstream infection or respiratory infection, and five reported on urinary tract infection. The risk ratio for the impact of initiating parenteral nutrition within 1 week on mortality rate was 0.95 (95% CI: 0.81–1.11), the risk ratio for the impact on bloodstream infections was 1.22 (95% CI: 1.02–1.46), the risk ratio for the impact on respiratory infections was 1.07 (95% CI: 0.87–1.32), the risk ratio for the impact on urinary tract infections was 1.12 (95% CI: 0.84–1.49), and bloodstream infections significantly increased.…”
Section: Cq13: Nutritionmentioning
confidence: 99%
“…It has been suggested, but without experimental proof, that a weekly increase of Ͼ40 mg/L in prealbumin concentrations reflects a switch to anabolism (12 ). An important observation was that patients in intensive care units (ICUs) receiving an approximately adequate nutritional intake showed a rise in prealbumin concentrations of ϳ40 mg/L during 1 week, whereas a control group receiving an inadequate intake still showed an increase, but it was somewhat smaller, at 20 mg/L, while CRP concentrations were decreasing substantially (13 ). In one ICU study, a loss of total body protein was observed along with an increase in prealbumin and a decrease in CRP (10 ).…”
mentioning
confidence: 99%
“…For example, in one study, ICU LOS was not affected by nutritional therapy that led to a rise in prealbumin (13 ), whereas in a small study of medical and surgical patients, Mears (15 ) found that when patients were classified as malnourished based on a local protocol, those patients who were randomized to receive nutritional supplementation had greater improvement in prealbumin, along with a significant reduction of 1-3 days in LOS compared with those receiving standard care. Moreover, in a landmark study performed more than 20 years ago, Bastow et al (16 ) showed that overnight enteral tube feeding in severely malnourished patients with femoral neck fracture led to a highly significant reduction of rehabilitation time in hospital, associated with an increase in prealbumin.…”
mentioning
confidence: 99%