Parenteral Zinc Supplementation Increases Pregnancy Rates in Beef Cows

Anchordoquy, Juan Mateo; Anchordoquy, Juan Patricio; Galarza, Esteban Martín; Farnetano, Nicolás Agustín; Giuliodori, Mauricio J.; Nikoloff, Noelia; Fazzio, Luis Emilio; Furnus, Cecilia Cristina

doi:10.1007/s12011-019-1651-8

Cited by 8 publications

(5 citation statements)

References 57 publications

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“…In general, the effect of the treatment, block and their interaction were not significant (p0.05). The latter is contradictory to published results in cows, where it was observed that the diameter of the preovulatory follicle increased with the injection of 400 mg of zinc oxide (Anchordoquy et al, 2019). This contradiction can be due to the day when the zinc oxide injection was applied, since in the case of the study in cows by Anchordoquy et al, supplementation was carried out at the beginning of the estrus synchronization protocol, which exposed the animal organism to the effects of zinc for a longer time.…”

Section: Resultscontrasting

confidence: 99%

“…In general, no dependency was observed between zinc injection and pregnancy rate (p0.05), which is similar to the results found in ewes supplemented orally with 50-150 ppm of zinc oxide (Monem & El-Shahat, 2011). This is contrary to the results reported in cows (Anchordoquy et al, 2019) and goats (Kundu et al, 2014), where an increase in pregnancy rate was observed by injecting 400 mg of zinc sulfate or by oral administration of 100 ppm of zinc oxide to goats. The beneficial effect of zinc supplementation on pregnancy rate is sustained, at least partly, on the blood concentrations of this mineral being higher in pregnant females than in empty ones (Nazari et al, 2019).…”

Section: Groupcontrasting

confidence: 99%

“…Zinc can be administrated to animals orally or by injection. The oral administration of zinc has been effective in improving the reproductive performance in ewes (Monem & El-Shahat, 2011) and goats (Kundu et al, 2014), while a similar effect of zinc injection has been observed in cows (Anchordoquy et al, 2019). The latter is considered as more effective in increasing endogenous zinc concentrations in sheep (Lamand et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy rate in ewes injected with zinc oxide during an estrus synchronization protocol

Corrales-Arévalo¹,

Lara

Hernández-Aquino³

et al. 2021

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Objective: To measure the effect of zin injection, during an estrus synchronization protocol, on pregnancy rate in sheep from the “Valle de Mexicali”.Design/methodology/approach: The experimental units were 157 ewes, which wereallocated in five farms (UP): UP1 (n=19), UP2 (n=27) UP3 (n=20) UP4 (n=71) and UP5(n=21). In each farm, the ewes were randomly assigned to one of three treatments:control, z-100 and z-200. The ewes from control groups were subcutaneously injectedwith 4 mL of olive oil as placebo. The ewes from groups z-100 and z-200 weresubcutaneously injected with 100 and 200 mg of zinc oxide. The response variableswere the preovulatory diameter of the largest follicle and pregnancy rate.Results: The differences between experimental groups on diameter of the largestpreovulatory follicle and pregnancy rates were not significant different (p>0.05). Limitations of the study/implications: The ewe’s reproductive response to zincinjection might be affected by the animal mineral status, it is recommended to carry onsupplementation with base on mineral blood concentrations.Conclusion: The subcutaneous injection with 100 or 200 mg of zinc oxide did not affectthe size of the largest preovulatory follicle and pregnancy rate in ewes.

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Section: Resultscontrasting

confidence: 99%

Section: Groupcontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pregnancy rate in ewes injected with zinc oxide during an estrus synchronization protocol

Corrales-Arévalo¹,

Lara

Hernández-Aquino³

et al. 2021

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“…Zinc is a vital trace element that plays a pivotal role in the maintenance of rumen microbiota and the synthesis of essential proteins, including collagen, glucagon, insulin, DNA, and RNA ( 105 ). It serves as an indispensable activator for a diverse array of enzymes, encompassing alkaline phosphatase, carbonic anhydrase, DNA and RNA polymerase, and, in conjunction with copper, superoxide dismutase, which assumes a key role in antioxidant processes ( 97 ).…”

Section: Trace Minerals Role In Bovine Mastitis Prevention During Per...mentioning

confidence: 99%

Enhancing bovine immune, antioxidant and anti-inflammatory responses with vitamins, rumen-protected amino acids, and trace minerals to prevent periparturient mastitis

Khan,

Huang,

Kou

et al. 2024

Front. Immunol.

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Mastitis, the inflammatory condition of mammary glands, has been closely associated with immune suppression and imbalances between antioxidants and free radicals in cattle. During the periparturient period, dairy cows experience negative energy balance (NEB) due to metabolic stress, leading to elevated oxidative stress and compromised immunity. The resulting abnormal regulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS), along with increased non-esterified fatty acids (NEFA) and β-hydroxybutyric acid (BHBA) are the key factors associated with suppressed immunity thereby increases susceptibility of dairy cattle to infections, including mastitis. Metabolic diseases such as ketosis and hypocalcemia indirectly contribute to mastitis vulnerability, exacerbated by compromised immune function and exposure to physical injuries. Oxidative stress, arising from disrupted balance between ROS generation and antioxidant availability during pregnancy and calving, further contributes to mastitis susceptibility. Metabolic stress, marked by excessive lipid mobilization, exacerbates immune depression and oxidative stress. These factors collectively compromise animal health, productive efficiency, and udder health during periparturient phases. Numerous studies have investigated nutrition-based strategies to counter these challenges. Specifically, amino acids, trace minerals, and vitamins have emerged as crucial contributors to udder health. This review comprehensively examines their roles in promoting udder health during the periparturient phase. Trace minerals like copper, selenium, and calcium, as well as vitamins; have demonstrated significant impacts on immune regulation and antioxidant defense. Vitamin B12 and vitamin E have shown promise in improving metabolic function and reducing oxidative stress followed by enhanced immunity. Additionally, amino acids play a pivotal role in maintaining cellular oxidative balance through their involvement in vital biosynthesis pathways. In conclusion, addressing periparturient mastitis requires a holistic understanding of the interplay between metabolic stress, immune regulation, and oxidative balance. The supplementation of essential amino acids, trace minerals, and vitamins emerges as a promising avenue to enhance udder health and overall productivity during this critical phase. This comprehensive review underscores the potential of nutritional interventions in mitigating periparturient bovine mastitis and lays the foundation for future research in this domain.

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“…Zinc (Zn) is a microelement that plays a crucial role in rumen microbiota maintenance and synthesis of proteins including collagen, glucagon, insulin, as well as in DNA and RNA synthesis [ 65 ]. Zn is an essential activator for the highest number of enzymes including alkaline phosphatase, carbonic anhydrase, DNA and RNA polymerase and (together with Cu) superoxide dismutase, which plays a key role in antioxidant processes [ 57 ].…”

Section: Zincmentioning

confidence: 99%

The Association between Selected Dietary Minerals and Mastitis in Dairy Cows—A Review

Libera

Konieczny

Witkowska

et al. 2021

Animals

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The aim of this paper is to describe the association between selected dietary minerals and mastitis in dairy cows. Minerals are a group of nutrients with a proven effect on production and reproductive performance. They also strongly affect immune system function. In particular their deficiencies may result in immunosuppression, which is a predisposing factor for udder inflammation occurrence. The role of selected dietary minerals (including calcium, phosphorus, magnesium, selenium, copper and zinc) has been reviewed. Generally, minerals form structural parts of the body; as cofactors of various enzymes they are involved in nerve signaling, muscle contraction and proper keratosis. Their deficiencies lead to reduced activity of immune cells or malfunction of teat innate defense mechanisms, which in turn promote the development of mastitis. Special attention was also paid to minerals applied as nanoparticles, which in the future may turn out to be an effective tool against animal diseases, including mastitis. To conclude, minerals are an important group of nutrients, which should be taken into account on dairy farms when aiming to achieve high udder health status.

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Parenteral Zinc Supplementation Increases Pregnancy Rates in Beef Cows

Cited by 8 publications

References 57 publications

Pregnancy rate in ewes injected with zinc oxide during an estrus synchronization protocol

Pregnancy rate in ewes injected with zinc oxide during an estrus synchronization protocol

Enhancing bovine immune, antioxidant and anti-inflammatory responses with vitamins, rumen-protected amino acids, and trace minerals to prevent periparturient mastitis

The Association between Selected Dietary Minerals and Mastitis in Dairy Cows—A Review

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