Parenthood following renal transplantation

Penn, Israel; Makowski, Edgar L.; Harris, Paula

doi:10.1038/ki.1980.130

Cited by 113 publications

(37 citation statements)

References 29 publications

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“…7,9,12 This high risk for preeclampsia has been described in renal transplant recipients as well and is therefore not an organ-specific phenomenon. 27,28,30 Management of preeclampsia in this population has been identical to that in the nontransplant population. The safety of commonly used therapeutic agents, such as magnesium, phenobarbital, calcium channel blockers, alphamethyldopa, hydralazine, and beta-blockers, has been assumed but not subjected to prospective trials.…”

Section: Discussionmentioning

confidence: 97%

“…In the case of both renal and hepatic transplantation, the risk for such complications is increased in those patients with prepregnancy renal dysfunction. 7,12,27,28 The risk for adverse maternal outcomes may be increased during the first 6 months after transplantation; most investigators advise waiting a full year before condoning pregnancy in these patients, although waiting times up to 2 years have been recommended by others. 3,16,29 Some reports have suggested that complications of pregnancy are more common in those women administered cyclosporine-based immunosuppression as opposed to tacrolimus-based regimens.…”

Section: Discussionmentioning

confidence: 99%

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Pregnancy after liver transplantation

et al. 2000

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The first known posttransplantation pregnancy was in 1958 in a renal transplant recipient who had received a kidney from her identical twin sister. The first known posttransplantation pregnancy in a liver transplant recipient was in 1978. Information available from female kidney transplant recipients helped in the decision making involved in the management of this case, as well as those that followed. Over the last 20 years, issues specific to liver transplantation and pregnancy have been identified. Similar to the kidney transplant recipient population, when prepregnancy recipient graft function is stable and adequate, pregnancy appears to be well tolerated. Also similar to kidney transplant recipients, there has been no evidence of a specific malformation pattern among the children, and although prematurity and low birth weight occur, overall newborn outcomes have been favorable. Pregnancy in the setting of recurrent liver disease, such as recurrent hepatitis C, poses a potential problem among liver transplant recipients, as well as the possible adverse effects of immunosuppression on maternal kidney function. Also of significance, peripartum graft deterioration has more severe consequences in this transplant recipient population. Therefore, pregnancy must be considered carefully in this transplant recipient group. Since 1991, the National Transplantation Pregnancy Registry (NTPR) has studied the safety of pregnancy outcomes in solid-organ transplant recipients. The purpose of this review is to catalog studies in the literature, as well as to present current data from the registry with management guidelines. (Liver Transpl 2000;6:671-685.)

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Pregnancy after liver transplantation

et al. 2000

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“…Penn et al [29] reported 67 pregnancies in the wives of 50 male recipients which resulted in 60 livebirths and 2 abortions; 5 pregnancies were in progress at the time of the report. 1 infant had a meningomyelocele and 1 infant died at birth with multiple congenital anomalies.…”

Section: Offspring Of Male Recipientsmentioning

confidence: 99%

“…The six reports -including our previous report [27] from transplant centers [9-13] (there are three reports from Denver [9,28,29] and the latest update by Penn et al [9]) will be utilized for this compi lation -include data on 107 pregnancies in 75 recipients. 24 of the 107 pregnancies were aborted (18 therapeutic); 83 pregnancies in 75 recipients resulted in 85 livebirths (1 stillbirth and 3 sets of twins).…”

Section: Patient Datamentioning

confidence: 99%

Pregnancy in Renal Allograft Recipients

Fine¹

1982

Am J Nephrol

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“…Management requires attention to blood pressure control, renal function, bone disease, anaemia and urinary tract infection (Penn et al 1980, Verco & Hawkins 1982. Meticulous assessment of fetal growth is needed and is best performed by serial ultrasound assessment.…”

Section: Management Of Pregnancymentioning

confidence: 99%

The Kidney in Pregnancy: A Review

Davison

1983

J R Soc Med

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Nephrological reviews are usually accolades to progress in the field. Advances pertaining to renal structure and function, techniques to study them, and understanding renal disease and its treatment by dialysis and transplantation are examples. Unfortunately, the area of nephrology which relates to pregnancy has not advanced similarly and when clinicians are asked to advise whether or not women with kidney disease, a renal transplant or a history of previous pregnancies marred by severe hypertension, should conceive or if pregnant continue the gestation, it becomes obvious that data are scarce and opinions vary. This neglect is unfortunate as renal and hypertensive complications of pregnancy remain an important cause of morbidity and mortality in mother and fetus. This review focuses on (a) the renal changes which occur during normal pregnancy, stressing the relevance to clinical practice; (b) controversies surrounding some of the urinary tract problems encountered in pregnancy; (c) detection and management of chronic renal disease and the effect of pregnancy 'on remote prognosis; (d) the kidney in pre-eclampsia; (e) pregnancy in renal transplant and haemodialysis patients; and (f) acute renal failure in obstetric practice.

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Parenthood following renal transplantation

Cited by 113 publications

References 29 publications

Pregnancy after liver transplantation

Pregnancy after liver transplantation

Pregnancy in Renal Allograft Recipients

The Kidney in Pregnancy: A Review

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