Parenthood in Survivors of Hodgkin Lymphoma: An EORTC-GELA General Population Case-Control Study

Kaaij, Marleen A. E. van der; Heutte, Natacha; Meijnders, Paul; Abeilard-Lemoisson, Edwige; Spina, Michele; Moser, Lotte; Allgeier, Anouk; Meulemans, Bart; Dubois, Brice; Simons, Arnold; Lugtenburg, Pieternella J.; Aleman, Berthe M.P.; Noordijk, Evert M.; Fermé, Christophe; Thomas, José; Stamatoullas, Aspasia; Fruchart, Christophe; Brice, Pauline; Gaillard, Isabelle; Doorduijn, Jeanette K.; Sebban, Catherine; Smit, Wilma G.J.M.; Bologna, Serge; Roesink, Judith M.; Ong, Francisca; André, Marc; Raemaekers, John; Henry-Amar, Michel; Kluin-Nelemans, Hanneke C.

doi:10.1200/jco.2011.40.8906

Cited by 32 publications

(28 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unexpectedly, the desire for a child could only be fulfilled by 30% of the patients. Compared to previous studies [18,32,33], the rate found in our study is low. This is likely to be related to the fact that 40% of our patients underwent allogeneic stem cell transplantation, which is known to cause lasting sterility in a high proportion of patients [34][35][36].…”

Section: Discussioncontrasting

confidence: 99%

“…While, at the time of diagnosis, patients that already had a child expressed a stronger desire for further parenthood than patients without a child, the opposite was true after the end of treatment [19]. In Hodgkin's lymphoma, patients that already had a child at the time of diagnosis had lower post-treatment birth rates than patients without a child [32].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Fertility preservation and fulfillment of parenthood after treatment of hematological malignancies: results from the ‘Aftercare in Blood Cancer Survivors’ (ABC) study

et al. 2020

View full text Add to dashboard Cite

Purpose Treatment of hematological malignancies carries the risk of lasting sterility. We aimed to identify fertility-related unmet needs. Methods The 'Aftercare in Blood Cancer Survivors' study is a cohort study of hematological patients who were in treatmentfree remission for ≥ 3 years or stable under continuous oral medication. Female patients age 18-45 years and male patients age 18-65 years without a history of pre-treatment infertility were asked to answer a structured questionnaire including questions addressing fertility issues. Multivariable analyses were performed to detect risk factors. Results Of 1562 study participants, 1031 met the inclusion criteria for the fertility sub-study. A high proportion of patients (72.4%) received information about the risk of losing fertility, but only a minority (15%) took steps to preserve it. Female and older patients were less likely to be informed. A post-treatment wish for parenthood was expressed by 19.3% of patients. It was strongly associated with childlessness at time of diagnosis and could be fulfilled by 29.4%. Fulfillment of desired parenthood increased with increasing time from diagnosis and was low after allogeneic transplantation. Conclusions Female and older hematological patients are less likely to be informed about fertility-related issues than other patients. With societal changes towards first parenthood at higher age, the proportion of patients desiring a child after treatment is likely to increase. Fulfillment of desired parenthood remains challenging, especially after allogeneic transplantation. Implications for cancer survivors In patients likely to express a wish for post-treatment parenthood, fertility-related issues should routinely be addressed before gonadotoxic treatment is started.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fertility preservation and fulfillment of parenthood after treatment of hematological malignancies: results from the ‘Aftercare in Blood Cancer Survivors’ (ABC) study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Data on effect estimates (HR, RR, RaR, and OR) of pregnancy and live birth were extracted from the remaining 18 articles, all of which were published in peer-reviewed journals between 2004 and 2018 (Byrne et al, 2004;Hodgson et al, 2007;Syse et al, 2007;Madanat et al, 2008;Cvancarova et al, 2009;Reulen et al, 2009;Pivetta et al, 2011;Stensheim et al, 2011;van der Kaaij et al, 2012;Baxter et al, 2013;Dillon et al, 2013;Hartman et al, 2013;Brämswig et al, 2015;Chow et al, 2016;Armuand et al, 2017;Anderson et al, 2018a;2018b;Thouvenin-Doulet et al, 2018). Details of the characteristics of the included studies are presented in TABLE 1.…”

Section: Resultsmentioning

confidence: 99%

Fertility in female cancer survivors: a systematic review and meta-analysis

Busnelli

Vitagliano

Mensi

et al. 2020

Reproductive BioMedicine Online

View full text Add to dashboard Cite

show abstract

“…Second, the participants represented 50.4% of the target population, which is lower than the proportions observed in surveys of the Dutch or Nordic general populations 17,18 but similar to that reported in the European Organization for Research and Treatment of Cancer survey of Hodgkin lymphoma survivors. 8 Third, the collected health data had no medical confirmation, and a memory bias cannot be excluded. Although targeted inquiries were used on the form, the possible bias probably concerns only health disorders that did not require permanent medication or that had no major impact on personal daily life.…”

Section: Discussionmentioning

confidence: 99%

“…The nonvalidated Life Situation Questionnaire (LSQ) addresses issues not available in other validated questionnaires, including the following sections: sociodemographic data, including marital status and highest level of education 6 ; parenthood data; education, work, and insurance; health situation, including height, weight, and detailed information on immediate post-treatment fatigue (within 3 years), post-treatment health disorders, and current treatments; and social situation. 7,8 The LSQ used targeted inquires to collect information. The weight (kg)-to-height (m) 2 ratio was used to calculate the body mass index (BMI) at the time of survivorship assessment; obesity was defined as a BMI ≥30 kg/m 2 .…”

Section: Questionnairesmentioning

confidence: 99%

Long‐term fatigue in survivors of non‐Hodgkin lymphoma: The Lymphoma Study Association SIMONAL cross‐sectional study

Mounier¹,

Anthony

Busson³

et al. 2019

Cancer

Self Cite

View full text Add to dashboard Cite

Background Long‐term survivors of non‐Hodgkin lymphoma (NHL) must cope with treatment complications and late toxicities that affect their health‐related quality of life. Little is known about the risk‐to‐benefit ratio of new agents like rituximab. The impact of treatment regimens and health disorders on long‐term fatigue levels was investigated in a cross‐sectional study. Methods Two self‐administered questionnaires, the 20‐item Multidimensional Fatigue Inventory (MFI‐20) and a Life Situation Questionnaire, were mailed in 2015 to NHL survivors enrolled onto 12 successive clinical studies (1993‐2010) conducted by the Lymphoma Study Association. Private addresses were obtained for 3317 survivors, of whom 1671 (50%) returned the questionnaires. Severe fatigue was defined as MFI‐20 scores ≥60 on dimension scales scored from 0 to 100. Linear regression models were used to assess factors that were linked to increased fatigue levels. Results The study population included 906 men and 765 women, and the median age was 64 years (age range, 24‐95 years). Overall, 811 survivors had received cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP)‐like chemotherapy, 518 had received high‐dose CHOP, and 342 had undergone upfront autologous stem cell transplantation; 829 survivors also had received rituximab. In total, 1100 survivors (66%) reported 1 or more late health disorders. Severe fatigue was reported by 602 survivors (37%). Increased fatigue levels were associated (P < .001) with increased age, obesity, and the presence of health disorders, but not with initial treatment or rituximab. Conclusions The survey confirms that high proportions long‐term NHL survivors have severe fatigue. The results suggest that initial treatment and the receipt of rituximab have no influence on the development of long‐term fatigue.

show abstract

Parenthood in Survivors of Hodgkin Lymphoma: An EORTC-GELA General Population Case-Control Study

Cited by 32 publications

References 40 publications

Fertility preservation and fulfillment of parenthood after treatment of hematological malignancies: results from the ‘Aftercare in Blood Cancer Survivors’ (ABC) study

Fertility preservation and fulfillment of parenthood after treatment of hematological malignancies: results from the ‘Aftercare in Blood Cancer Survivors’ (ABC) study

Fertility in female cancer survivors: a systematic review and meta-analysis

Long‐term fatigue in survivors of non‐Hodgkin lymphoma: The Lymphoma Study Association SIMONAL cross‐sectional study

Contact Info

Product

Resources

About