Parenting and plasticity

Leuner, Benedetta; Glasper, Erica R.; Gould, Elizabeth

doi:10.1016/j.tins.2010.07.003

Cited by 144 publications

(111 citation statements)

References 115 publications

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“…Sire behaviour was qualitatively similar to maternal behaviour but was less efficient in that male response levels were slower and less frequent. The 50–60% of sires that showed parental behaviour in this study is similar to the proportion reported in other rodents246781727.…”

Section: Discussionsupporting

confidence: 88%

Displays of paternal mouse pup retrieval following communicative interaction with maternal mates

et al. 2013

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Compared with the knowledge of maternal care, much less is known about the factors required for paternal parental care. Here we report that new sires of laboratory mice, though not spontaneously parental, can be induced to show maternal-like parental care (pup retrieval) using signals from dams separated from their pups. During this interaction, the maternal mates emit 38-kHz ultrasonic vocalizations to their male partners, which are equivalent to vocalizations that occur following pheromone stimulation. Without these signals or in the absence of maternal mates, the sires do not retrieve their pups within 5 min. These results show that, in mice, the maternal parent communicates to the paternal parent to encourage pup care. This new paradigm may be useful in the analysis of the parental brain during paternal care induced by interactive communication.

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Section: Discussionsupporting

confidence: 88%

Displays of paternal mouse pup retrieval following communicative interaction with maternal mates

et al. 2013

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“…43–45 Nurses’ support of mothers’ efforts to protect themselves and their offspring 46 is likely to buffer the damaging effects of toxic stress on mothers’ rapidly changing neural circuitry and behavior during pregnancy and the puerperium. 43–48 …”

Section: Discussionmentioning

confidence: 99%

Effect of Home Visiting by Nurses on Maternal and Child Mortality

et al. 2014

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IMPORTANCE Mothers and children living in adverse contexts are at risk of premature death. OBJECTIVE To determine the effect of prenatal and infant/toddler nurse home visiting on maternal and child mortality during a 2-decade period (1990–2011). DESIGN, SETTING, AND PARTICIPANTS A randomized clinical trial was designed originally to assess the home visiting program’s effect on pregnancy outcomes and maternal and child health through child age 2 years. The study was conducted in a public system of obstetric and pediatric care in Memphis, Tennessee. Participants included primarily African American women and their first live-born children living in highly disadvantaged urban neighborhoods, who were assigned to 1 of 4 treatment groups: treatment 1 (transportation for prenatal care [n = 166]), treatment 2 (transportation plus developmental screening for infants and toddlers [n = 514]), treatment 3 (transportation plus prenatal/postpartum home visiting [n = 230]), and treatment 4 (transportation, screening, and prenatal, postpartum, and infant/toddler home visiting [n = 228]). Treatments 1 and 3 were included originally to increase statistical power for testing pregnancy outcomes. For determining mortality, background information was available for all 1138 mothers assigned to all 4 treatments and all but 2 live-born children in treatments 2 and 4 (n = 704). Inclusion of children in treatments 1 and 3 was not possible because background information was missing on too many children. INTERVENTIONS Nurses sought to improve the outcomes of pregnancy, children’s health and development, and mothers’ health and life-course with home visits beginning during pregnancy and continuing through child age 2 years. MAIN OUTCOMES AND MEASURES All-cause mortality in mothers and preventable-cause mortality in children (sudden infant death syndrome, unintentional injury, and homicide) derived from the National Death Index. RESULTS The mean (SE) 21-year maternal all-cause mortality rate was 3.7% (0.74%) in the combined control group (treatments 1 and 2), 0.4% (0.43%) in treatment 3, and 2.2% (0.97%) in treatment 4. The survival contrast of treatments 1 and 2 combined with treatment 3 was significant (P = .007); the contrast of treatments 1 and 2 combined with treatment 4 was not significant (P = .19), and the contrast of treatments 1 and 2 combined with treatments 3 and 4 combined was significant (post hoc P = .008). At child age 20 years, the preventable-cause child mortality rate was 1.6% (0.57%) in treatment 2 and 0.0% (SE not calculable) in treatment 4; the survival contrast was significant (P = .04). CONCLUSIONS AND RELEVANCE Prenatal and infant/toddler home visitation by nurses is a promising means of reducing all-cause mortality among mothers and preventable-cause mortality in their first-born children living in highly disadvantaged settings.

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“…Thus, in utero exposure to stress or to a variety of pharmacological agents almost invariably reduces neurogenesis in adulthood (Korosi et al 2012). Postnatal exposure to stress yields more variable results, and is modified by maternal and paternal factors, sex, genetic background, and epigenetic changes, although suppression of neurogenesis prevails here as well (Leuner et al 2010;Lucassen et al 2010aLucassen et al ,b, 2013bKoehl et al 2012;Loi et al 2014). Neuronal survival was decreased and apoptosis was increased in offspring of lowcaring mothers versus offspring of high-caring mothers (Weaver et al 2002;Bredy et al 2003).…”

Section: Long-lasting Effects Of Perinatal Stress Exposurementioning

confidence: 99%