Parents’ concerns regarding their ART children

Fisher-Jeffes, L J; Banerjee, Indrani; Sutcliffe, Alastair

doi:10.1530/rep.1.00842

Cited by 15 publications

(9 citation statements)

References 23 publications

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“…Of particular concern will be the future fertility of ART offspring. It may be that the procedures involved could affect this (Fisher-Jeffes et al, 2006). Furthermore, ICSI-conceived boys, in particular, may be at risk of inheriting paternal sex-chromosome-encoded disorders (Feng et al, 2008;Kurinczuk, 2003) and…”

Section: Other Outcomesmentioning

confidence: 99%

Health and disease in children born after assistive reproductive therapies (ART)

Hyrapetian

Loucaides

Sutcliffe³

2014

Journal of Reproductive Immunology

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Section: Other Outcomesmentioning

confidence: 99%

Health and disease in children born after assistive reproductive therapies (ART)

Hyrapetian

Loucaides

Sutcliffe³

2014

Journal of Reproductive Immunology

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“…Children were recruited from an established cohort in the UK as part of a longitudinal study into outcomes in assisted-conception children Fisher-Jeffes et al, 2006;Ponjaert-Kristoffersen et al, 2005;Sutcliffe et al, 2001Sutcliffe et al, , 2003. Twins and higher order births were excluded from the study, and all children were born at 32 weeks of gestation or later.…”

Section: Subjectsmentioning

confidence: 99%

Growth of children conceived by IVF and ICSI up to 12years of age

Basatemür

Shevlin²,

Sutcliffe

2010

Reproductive BioMedicine Online

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Recent studies have given conflicting results regarding growth in children born following assisted reproductive treatments up to the age of 18years. It has been suggested that children conceived via IVF may be taller than naturally conceived children and that this may due to subtle epigenetic alteration of imprinted genes as a result of the IVF process. A prospective match-controlled study was performed to investigate the growth of children born in the UK following standard IVF and intracytoplasmic sperm injection (ICSI) up to the age of 12years. The study assessed 143 IVF and 166 ICSI children with 173 matched naturally conceived controls. Primary end-points were height and weight at various time points: birth, 5years, 7-9years and 10-12years. In addition, head circumference was assessed at birth. No significant differences were observed regarding head circumference, height and weight between the three groups at any of the time points. In conclusion, this preliminary study provides reassuring information regarding the growth of IVF and ICSI children up to 12years. Further studies must continue to investigate the growth and other outcomes in assisted-conception children as they develop through puberty into early adulthood.

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“…Assisted reproductive technology (ART) usage has increased annually since the first live birth in 1978, with over 8 million children born after ART globally. 1 This increased utilisation of ART has occurred concurrently with developments in our understanding of the impact of the early life environment on long-term health 2–4 and most families with ART conceived children reported potential general health risks to their children as their paramount concern, 5 6 resulting in a concomitant increase in focus on the potential adverse short-term and long-term effects on offspring.…”

Section: Introductionmentioning

confidence: 99%

Cohort profile: a national, population-based cohort of children born after assisted conception in the UK (1992–2009): methodology and birthweight analysis

et al. 2021

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PurposeTo generate a large cohort of children born after assisted reproductive technology (ART) in the UK between 1992 and 2009, their naturally conceived siblings (NCS) and matched naturally conceived population (NCP) controls and linking this with health outcome data to allow exploration of the effects of ART. The effects of fresh and frozen embryo transfer on birth weight (BW) were analysed to test the validity of the cohort.ParticipantsChildren recorded on the Human Fertilisation and Embryology Authority (HFEA) register as being born after ART between 1992 and 2009, their NCS and matched NCP controls linked to Office for National Statistics birth registration dataset (HFEA-ONS cohort). This cohort was further linked to the UK Hospital Episode Statistics database to allow monitoring of the child’s post-natal health outcomes up to 2015 (HFEA-ONS-HES subcohort).Findings to dateThe HFEA-ONS cohort consisted of 75 348 children born after non-donor ART carried out in the UK between 1 April 1992 and 31 July 2009 and successfully linked to birth registration records, 14 763 NCS and 164 823 matched NCP controls. The HFEA-ONS-HES subcohort included 63 877 ART, 11 343 NCS and 127 544 matched NCP controls further linked to health outcome data. The exemplar analysis showed that children born after fresh embryo transfers were lighter (BW difference: −131 g, 95% CI: −140 to –123) and those born after frozen embryo transfers were heavier (BW difference: 35 g, 95% CI: 19 to 52) than the NCP controls. The within-sibling analyses were directionally consistent with the population control analyses, but attenuated markedly for the fresh versus natural conception (BW difference: −54 g; 95% CI: −72 to –36) and increased markedly for the frozen versus natural conception (BW difference: 152 g; 95% CI: 113 to 190) analyses.Future plansTo use this cohort to explore the relationship between ART conception and short-term and long-term health outcomes in offspring.

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Parents’ concerns regarding their ART children

Cited by 15 publications

References 23 publications

Health and disease in children born after assistive reproductive therapies (ART)

Health and disease in children born after assistive reproductive therapies (ART)

Growth of children conceived by IVF and ICSI up to 12years of age

Cohort profile: a national, population-based cohort of children born after assisted conception in the UK (1992–2009): methodology and birthweight analysis

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