For cloud providers, workload prediction is a challenging task due to irregular incoming workloads from users. Accurate workload prediction is essential for scheduling the resources to the cloud applications. Thus, in this paper, the authors propose a predictive cloud workload management framework to estimate the needed resources in advance based on a hybrid approach, which is a combination of an improved Long Short-Term Memory (LSTM) network and a multilayer perceptron network. By improving the traditional LSTM architecture by using opposition-based differential evolution algorithm and dropout technique on recurrent connection without memory loss, the proposed approach has the ability to perform a better prediction process. A novel hybrid predictive approach is aiming at enhancing the prediction performance of the cloud workload. Finally, the authors measure the proposed approach’s effectiveness under benchmark data sets of NASA and Saskatchewan servers. The experimental results proved that the proposed approach outperforms the other conventional methods.