Parietal Cell Antibodies among Peruvians with Gastric Pathologic Changes

Kohlstadt, Ingrid; Mayolo, E. A. Antunez de; Gilman, Robert H.; León-Barúa, Raúl; Ramírez-Ramos, Alberto; Rodriguez, Christina; Recavarren, Sixto; Spira, William M.; Watanabe, José; Berenson, RJ; Guevara, Cinthya Cecilia Zelada Ladrón de; Palomino, Juan Carlos; Álvarez, María Inés Ortíz; Cok, Jaime; Ramírez-Icaza, C.

doi:10.3109/00365529309098294

Cited by 6 publications

(5 citation statements)

References 18 publications

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“…We did not find a statistically significant association between GA and antiparietal cell antibodies in this study, and this is in keeping with the work of Kohlstadt et al [27] who found that these antibodies are unrelated to Hp infection and the pathological changes associated with it.…”

Section: Discussionsupporting

confidence: 80%

Lack of Association between Helicobacter pylori and Gastric Atrophy or Intestinal Metaplasia in Elderly Patients

Liston

Ma²,

Ak³

1996

Gerontology

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Helicobacter pylori (Hp) is associated with gastritis and peptic ulcers. It may also induce gastric atrophy (GA) and intestinal metaplasia (IM), and these changes may be the precursors of gastric carcinoma. The aim of this study was to determine if GA or IM is associated with Hp infection in elderly patients. Consecutive patients admitted for gastroscopy were recruited. Multiple biopsies were taken for histology and rapid urease (CLO) tests along with IgG enzyme-linked immunosorbent assay antibodies and ¹³C-urea breath tests. Statistical analysis was by χ² tests. 114 patients were recruited, the average age was 78.9 ± 5.4 years. Histology was available on 105 patients, 80 (76.2%) had gastritis, and 61/80 (76.25%) had evidence of definite current Hp infection. Seven patients had reflux gastritis, and these were excluded from the analysis described below. 20 patients had GA and 24 IM. The relationship between Hp and GA or IM was investigated by dividing patients into four groups: Group 1 patients (n = 57) were taken to be definitely currently infected (GA 7 patients, IM 11, both 1). Group 2 patients (n = 18) had old infection (GA 2, IM 4, both 3). Group 3 patients (n = 16) have never been infected previously (GA 1, IM 1, both 3). Group 4 patients (n = 4) had a poor immunological response to Hp (GA 1, IM 1, both 0). There were no significant differences in the numbers of patients with GA or IM in any group as compared with any other, with the exception of less patients with histological evidence of combined GA and IM among patients with definite current infection as compared with those with either previous infection (p = 0.04) or ‘never’ infection (p = 0.03). We conclude that the mucosal changes of GA or IM are not consistently associated with Hp infection in the elderly.

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Section: Discussionsupporting

confidence: 80%

Lack of Association between Helicobacter pylori and Gastric Atrophy or Intestinal Metaplasia in Elderly Patients

Liston

Ma²,

Ak³

1996

Gerontology

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“…On these bases, it may be suggested that in some patients, H. pylori infection per se may induce a parietal damage with consequent autoimmune responses. The former hypothesis is supported further by studies in Peruvians with gastric pathological changes, wherein was found a 12% prevalence of PCAs unrelated to any specific gastric disease [33].…”

Section: Discussionmentioning

confidence: 69%

Atrophic Body Gastritis: Distinct Features Associated with Helicobacter pylori Infection

et al. 1997

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“…A correlation between H. pylori and gastric antibodies has been reported in some [21][22][23][24][25] but not all studies. 15,54 We observed an association between H. pylori and PCA when the cut-off point of PCA-positivity was ‡ 1/20, but not anymore when it was ‡ 1/40, suggesting that low PCA titres might reflect H. pylori infection. The HLA-bound susceptibility to H. pylori infection and to PCA differed in this study.…”

Section: Histological Datamentioning

confidence: 73%

“…Cohort follow‐up studies have suggested a 0.3–2% annual increase of atrophic corpus gastritis in subjects with H. pylori ‐positive gastritis 14 , . 52 , 53 However, others have found no or a negative link between H. pylori and atrophic corpus gastritis, 15 , 44 , 54 and earlier studies, for historical reasons, did not report the H. pylori status 55 , . 56 We observed no association between H. pylori status and pre‐atrophic autoimmune gastritis, when the mucosa is still hospitable for H. pylori , and we identified PCA and gastrin as risk markers for autoimmune gastritis.…”

Section: Discussionmentioning

confidence: 96%

Helicobacter pylori, parietal cell antibodies and autoimmune gastropathy in type 1 diabetes mellitus

Block

Leeuw

Bogers

et al. 2002

Aliment Pharmacol Ther

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Background: Fifteen to 20% of type 1 diabetic patients exhibit parietal cell antibodies (PCA), which are associated with autoimmune gastritis, hypochlorhydria, iron deficiency and pernicious anaemia. Aim: To examine whether Helicobacter pylori infection could explain the high prevalence of PCA and autoimmune gastropathy in diabetes. If so, H. pylori eradication could prevent autoimmune gastritis. Methods: In 229 type 1 diabetics (M/F: 135/94; age: 41 ± 12 years) PCA were measured. H. pylori infection was assessed by serology, urea breath test in all and by histology (updated Sydney system) in 88 subjects. Pentagastrin tests were performed in 42 patients. Results: Sixty‐nine patients were PCA‐positive. H. pylori infection was present in 72 patients and was negatively associated with HLA‐DQA1*0103‐B1*0603 (OR=0.12, P=0.015) and positively with DQA1*0501‐B1*0201 (OR=1.9, P=0.032). PCA‐positivity was linked to HLA‐DQA1*0501‐B1*0301 (OR=3.9, P=0.017). A link between H. pylori and PCA was observed when PCA‐positivity was defined as a titre ≥ 1/20 (OR=2.0, P=0.03), but not if ≥ 1/40 was the cut‐off point. PCA‐positivity, but not H. pylori infection, was associated with iron deficiency anaemia (OR=2.7, P=0.008), pernicious anaemia (OR= 33.5, P < 0.0001), hypochlorhydria (OR=12.1, P=0.0008) and autoimmune gastritis (OR=12.5, P < 0.0001). Conclusions: The HLA‐bound susceptibility of H. pylori and PCA differed. PCA‐positivity but not ongoing H. pylori infection is associated with autoimmune gastritis. Low titres of PCA might reflect H. pylori infection rather than autoimmune gastropathy.

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Parietal Cell Antibodies among Peruvians with Gastric Pathologic Changes

Cited by 6 publications

References 18 publications

Lack of Association between <i>Helicobacter pylor</i><i>i</i> and Gastric Atrophy or Intestinal Metaplasia in Elderly Patients

Lack of Association between <i>Helicobacter pylor</i><i>i</i> and Gastric Atrophy or Intestinal Metaplasia in Elderly Patients

Atrophic Body Gastritis: Distinct Features Associated with Helicobacter pylori Infection

Helicobacter pylori, parietal cell antibodies and autoimmune gastropathy in type 1 diabetes mellitus

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