Parietal Cortex Integrates Object Orientation and Saccade Signals to Update Grasp Plans

Baltaretu, Bianca R.; Monaco, Simona; Velji-Ibrahim, Jena; Luabeya, Gaelle N.; Crawford, J. Douglas

doi:10.1101/758532

Cited by 8 publications

(90 citation statements)

References 63 publications

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“…Figure 4a provides a general overview of the data used in this calculation, showing Saccade > Fixation modulations during the updating portion of our task and for reference, the same contrast from our saccade localizer task, where participants simply looked back and forth between two points (see Methods for details). As in our previous study [24], saccade modulations were generally more widespread when they accompanied a more complex task. Figure 4b shows that the location of the vPCu site used for our hypothesis testing bordered on the edge of a major cluster of saccade modulation.…”

Section: Hypothesis 2: Task-specific Saccade Modulationssupporting

confidence: 83%

“…Our previous study of transsaccadic orientation updating showed a functional network connecting right SMG to both saccade and grasp motor areas [24]. Here, we provide a similar analysis of precuneus activity for the current perceptual task.…”

Section: Hypothesis 2: Task-specific Saccade Modulationssupporting

confidence: 58%

“…Consistent with these findings, transcranial magnetic stimulation (TMS) of PPC (just posterior to SMG) disrupted transsaccadic memory of multiple object orientations [22,23]. SMG activity is also modulated during transsaccadic updating of object orientation for grasp, along with other parietal sensorimotor areas [24]. These findings implicate PPC in the transsaccadic updating of both object location and orientation.…”

Section: Introductionmentioning

confidence: 58%

“…3a, but raised the statistical threshold until only the peak site of parietal activation remained, corresponding to ventral precuneus (vPCu). We then used BrainVoyager (BrainVoyager QX v2.8, Brain Innovation) to determine the cluster of activation around the peak voxel and extract data for prediction testing [24,31,32]. This site is shown in Fig.…”

Section: Selection Of Parietal Site For Hypothesis Testingmentioning

confidence: 99%

“…As in Dunkley et al [20], we first localized clusters that were activated by changes in stimulus frequency following saccades; then, as in Baltaretu et al [24] we determined if the site(s) of peak PPC activation passed two additional criteria: their feature modulations must be saccade-specific ( Fig. 2, prediction 1), and 2) they must show task-specific saccade modulations relative to a simple saccade motor task (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Parietal Mechanisms for Transsaccadic Spatial Frequency Perception: An fMRI Study

Baltaretu

Dunkley

Stevens

et al. 2020

Preprint

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Posterior parietal cortex (PPC), specifically right supramarginal gyrus, is involved in transsaccadic memory of object orientation for both perception and action. Here, we investigated whether PPC is involved in transsaccadic memory of other features, namely spatial frequency. We employed a functional magnetic resonance imaging paradigm where participants briefly viewed a grating stimulus with a specific spatial frequency that later reappeared with the same or different frequency, after a saccade or continuous fixation. Post-saccadic frequency modulation activated a region in the right hemisphere spanning medial PPC (ventral precuneus) and posterior cingulate cortex. Importantly, the site of peak precuneus activation showed saccade-specific feature modulation (compared to fixation) and task-specific saccade modulation (compared to a saccade localizer task). Psychophysiological interaction analysis revealed functional connectivity between this precuneus site and the precentral gyrus (M1), lingual gyrus (V1/V2), and medial occipitotemporal sulcus. This differed from the transsaccadic orientation network, perhaps because spatial frequency signaled changes in object identity. Overall, this experiment supports a general role for PPC in transsaccadic vision, but suggests that different networks are employed for specific features.

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Section: Hypothesis 2: Task-specific Saccade Modulationssupporting

confidence: 83%

Section: Hypothesis 2: Task-specific Saccade Modulationssupporting

confidence: 58%

Section: Introductionmentioning

confidence: 58%

Section: Selection Of Parietal Site For Hypothesis Testingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Parietal Mechanisms for Transsaccadic Spatial Frequency Perception: An fMRI Study

Baltaretu

Dunkley

Stevens

et al. 2020

Preprint

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Brain Reactions to Opening and Closing the Eyes: Salivary Cortisol and Functional Connectivity

et al. 2022

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This study empirically assessed the strength and duration of short-term effects induced by brain reactions to closing/opening the eyes on a few well-known resting-state networks. We also examined the association between these reactions and subjects’ cortisol levels. A total of 55 young adults underwent 8-min resting-state fMRI (rs-fMRI) scans under 4-min eyes-closed and 4-min eyes-open conditions. Saliva samples were collected from 25 of the 55 subjects before and after the fMRI sessions and assayed for cortisol levels. Our empirical results indicate that when the subjects were relaxed with their eyes closed, the effect of opening the eyes on conventional resting-state networks (e.g., default-mode, frontal-parietal, and saliency networks) lasted for roughly 60-s, during which we observed a short-term increase in activity in rs-fMRI time courses. Moreover, brain reactions to opening the eyes had a pronounced effect on time courses in the temporo-parietal lobes and limbic structures, both of which presented a prolonged decrease in activity. After controlling for demographic factors, we observed a significantly positive correlation between pre-scan cortisol levels and connectivity in the limbic structures under both conditions. Under the eyes-closed condition, the temporo-parietal lobes presented significant connectivity to limbic structures and a significantly positive correlation with pre-scan cortisol levels. Future research on rs-fMRI could consider the eyes-closed condition when probing resting-state connectivity and its neuroendocrine correlates, such as cortisol levels. It also appears that abrupt instructions to open the eyes while the subject is resting quietly with eyes closed could be used to probe brain reactivity to aversive stimuli in the ventral hippocampus and other limbic structures.

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Choice activity stabilizes sensory representations and mediates sensorimotor associations in parietal cortex

Chang

Doudlah

Kim

et al. 2020

Preprint

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33Selecting actions which achieve desired goals often requires three-dimensional (3D) 34representations of the environment. Because the sensory epithelia cannot directly encode the 35 world's 3D spatial features, sensory signals must be converted into 3D representations. Here we 36 investigated the relationships between the quality of 3D visual representations, choice-related 37 activity, and motor-related activity in the parietal cortex of macaque monkeys using an eight-38 alternative 3D orientation discrimination task, visually guided saccade task, and laminar probe 39 recordings. We found that choice activity was preferentially carried by caudal intraparietal area 40 neurons with more robust 3D representations. Choice activity further stabilized the 3D 41representations, rather than attenuating information not directly relevant to the behavioral task 42 (nuisance variables). An experience-dependent, sensorimotor association additionally aligned 43 sensory and saccade direction preferences, particularly for neurons with choice activity. These 44 findings reveal novel roles for choice activity in improving the fidelity of ecologically relevant object 45 representations and mediating sensorimotor associations. 46 (Tsutsui et al., 2001;Van Dromme et al., 2016). 67 47The anatomical projections and effective connectivity of CIP suggest that it may also 68 contribute to goal-directed sensorimotor transformations (Nakamura et al., 2001; Premereur et 69 al., 2015;Van Dromme et al., 2016; Lanzilotto et al., 2019). In particular, CIP projects to areas 70 involved in motor planning and execution, including the lateral intraparietal area (LIP) (Andersen 71 et al., 1992;Bennur and Gold, 2011;Shushruth et al., 2018), anterior intraparietal area (Murata 72 et al., 2000;Baumann et al., 2009;Pani et al., 2014), and V6A (Fattori et al., 2010; Fattori et al., 73 2012;Breveglieri et al., 2016). However, it is untested if CIP carries motor-related signals, or if its 74 output only contains 3D sensory information. 75Here we investigated the relationships between sensory representations, choice-related 76 activity, and motor-related activity in CIP. Neuronal activity was recorded while macaque monkeys 77 performed an eight-alternative forced choice (8AFC) tilt discrimination task with planar surfaces 78 presented at different slants and distances . The neurons differed in the extent 79 to which their 3D orientation selectivity depended on distance. Choice activity was preferentially 80 carried by neurons with more robust 3D representations, and further stabilized 3D selectivity. 81Choice tuning was parametric, and the choice and tilt preferences aligned. Motor-related activity 82 was assessed using a visually guided saccade task (Munoz and Wurtz, 1995; Hanes and Schall, 83 1996). We found that many CIP neurons had saccade direction tuning. Moreover, the surface tilt 84 and saccade direction preferences were mapped onto one another, reflecting a sensorimotor 85 association that was strongest for neurons with choice acti...

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Parietal Cortex Integrates Object Orientation and Saccade Signals to Update Grasp Plans

Cited by 8 publications

References 63 publications

Parietal Mechanisms for Transsaccadic Spatial Frequency Perception: An fMRI Study

Parietal Mechanisms for Transsaccadic Spatial Frequency Perception: An fMRI Study

Brain Reactions to Opening and Closing the Eyes: Salivary Cortisol and Functional Connectivity

Choice activity stabilizes sensory representations and mediates sensorimotor associations in parietal cortex

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