Parietal peritoneal healing in the rat

Human Peritoneal Adhesions Show Evidence of Tissue Remodeling and Markers of Angiogenesis

“…7 The greater omentum is the most common tissue involved in adhesion formation 8 and omental adhesions form most rapidly. 9 Although it is a highly vascularized tissue, it is unclear whether omental adhesions have distinct properties. 10 Animal studies have suggested that adhesions form to provide a vascular bridge to ischemic areas of bowel after surgery, but with time become avascular fibrous structures.…”

The healing of peritoneum under normal and pathological conditions

“…Proliferating cells appeared to spread out from these islands to form most of the new mesothelium, although some healing also took place from mesothelium at thc periphery of the wound. Johnson and Whitting (1962) and Bridges and Whitting (1964) investigated the repair of parietal peritoneum in the rabbit and rat respectively. They supported the conclusions of Cameron and others (1957), but also suggested that in some circumstances macrophages might contribute to the healing process by transforming into mesothelial cells.…”

Cellular Events in Adhesion Formation due to Thermal Trauma

“…Although numerous experimental models for adhesion formation, relying on various types of trauma, have been proposed, there are only a few detailed descriptions of the histopathological events consequent to the trauma [1,3,5,8], In our thermal trauma model, the sequence of events leading to ad hesion formation was as follows: destruction of the serosa, necrosis, and an inflammatory infiltration in the intestinal wall; within 48 h, various organs were already attached to the damaged area and the inflammatory process then extended to them. With the appearance of fibroblasts and blood vessels the adhesions became stable, and since they formed in only some of the treated mice, a comparison in the intensity of the lesion could be made between mice with and without adhesions.…”