Parieto‐frontal network in humans studied by cortico‐cortical evoked potential

Matsumoto, Riki; Nair, Dileep; Ikeda, Akio; Fumuro, Tomoyuki; LaPresto, Eric; Mikuni, Nobuhiro; Bingaman, William; Miyamoto, Susumu; Fukuyama, Hidenao; Takahashi, Ryōsuke; Najm, Imad; Shibasaki, Hiroshi; Lüders, Hans

doi:10.1002/hbm.21407

Cited by 119 publications

(84 citation statements)

References 94 publications

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“…Our recent studies favor the direct cortico-cortical connection. The parieto-frontal CCEP connectivity study showed a linear correlation between the N1 peak latency and the surface distance from the parietal stimulus site to the frontal maximum response site (Figure 1A) [30]. This observation favors the direct cortico-cortical white matter pathway, because the longer the surface distance is, the proportionally longer the actual white matter pathway connecting the two cortical sites and, accordingly, its traveling time is.…”

Section: Ccep Methodologymentioning

confidence: 96%

Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy

Matsumoto

Kunieda

Nair

2017

Seizure

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In the last decade, single pulse electrical stimulation (SPES) has been used as an investigational tool in the field of epilepsy surgery. Direct cortical stimulation applied at a frequency of ∼1 Hz can probe cortico-cortical connections by averaging electrocorticogram time-lock to the stimuli (2 x 20–30 trials). These evoked potentials that emanate from adjacent and remote cortices have been termed cortico-cortical evoked potentials (CCEPs). Although limited to patients undergoing invasive presurgical evaluations with intracranial electrodes, CCEP provides a novel way to explore inter-areal connectivity in vivo in the living human brain to probe functional brain networks such as language and cognitive motor networks. In addition to its impact on systems neuroscience, this method, in combination with 50 Hz electrical cortical stimulation, could contribute clinically to map the functional brain systems by tracking the cortico-cortical connections among the functional cortical regions in each individual patient. This approach may help identify the normal cortico-cortical network within pathology as well as reveal connections that might arise from neural plasticity. Because of its high practicality, it has been recently applied for intraoperative monitoring of the functional brain networks for patients with brain tumor. With regard to epilepsy, SPES has been used for the two major purposes, one to probe cortical excitability of the focus, namely, epileptogenicity, and the other to probe seizure networks. Both early (i.e., CCEP) and delayed responses, and probably their high frequency oscillation counterparts, are regarded as a surrogate marker of epileptogenicity. With regards to its impact on the human brain connectivity map, worldwide collaboration is warranted to establish the standardized CCEP connectivity map as a solid reference for non-invasive connectome researches.

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Section: Ccep Methodologymentioning

confidence: 96%

Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy

Matsumoto

Kunieda

Nair

2017

Seizure

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150

160

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“…A left EOG electrode placed 2.5 cm below and 2.5 cm lateral to the left outer canthus showed a small signal deflection (Supplementary Figure S1). A previous human study using cortico-cortical evoked potentials suggested cortico-cortical propagation to be as rapid as 40 ms per 10 cm (Matsumoto et al, 2012), whereas the distance between the lower-order visual cortex and the orbitofrontal cortex is about 15 cm (Thiebaut de Schotten et al, 2012). Taken together, we failed to collect external evidence supporting that the orbitofrontal cortex receives ‘macroelectrode-detectable’ signals triggered by the lower-order visual cortex as rapidly as 130 ms following the image presentation.…”

Section: Discussionmentioning

confidence: 99%

Gamma activity modulated by naming of ambiguous and unambiguous images: Intracranial recording

Cho-Hisamoto

Kojima

Brown

et al. 2015

Clinical Neurophysiology

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OBJECTIVE Humans sometimes need to recognize objects based on vague and ambiguous silhouettes. Recognition of such images may require an intuitive guess. We determined the spatial-temporal characteristics of intracranially-recorded gamma activity (at 50–120 Hz) augmented differentially by naming of ambiguous and unambiguous images. METHODS We studied ten patients who underwent epilepsy surgery. Ambiguous and unambiguous images were presented during extraoperative electrocorticography recording, and patients were instructed to overtly name the object as it is first perceived. RESULTS Both naming tasks were commonly associated with gamma-augmentation sequentially involving the occipital and occipital-temporal regions, bilaterally, within 200 ms after the onset of image presentation. Naming of ambiguous images elicited gamma-augmentation specifically involving portions of the inferior-frontal, orbitofrontal, and inferior-parietal regions at 400 ms and after. Unambiguous images were associated with more intense gamma-augmentation in portions of the occipital and occipital-temporal regions. CONCLUSIONS Frontal-parietal gamma-augmentation specific to ambiguous images may reflect the additional cortical processing involved in exerting intuitive guess. Occipital gamma-augmentation enhanced during naming of unambiguous images can be explained by visual processing of stimuli with richer detail. SIGNIFICANCE Our results support the theoretical model that guessing processes in visual domain occur following the accumulation of sensory evidence resulting from the bottom-up processing in the occipital-temporal visual pathways.

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“…CCEPs obtained with standard ('macro-') ECoG electrodes are increasingly utilized to probe cortical connectivity, such as in the human language, motor cortex, and frontal/parietal networks [7][8][9], or subcortical structures [13], as well as to explore pathological connectivity in epilepsy [17]. As they are perturbation-based, CCEPs can unequivocally show directed (causal) connectivity between remote areas [11,12], which is challenging to achieve by analysis of undisturbed brain dynamics.…”

Section: Discussionmentioning

confidence: 99%

“…This well-established method allows one to unravel functional connectivity in the cortex [7][8][9][10][11][12] or subcortical regions [13], and recent studies used ECoG-based SPES in humans to investigate CCEPassociated changes in the spectral domain [14,15]. For reviews on studies investigating cortical connectivity by means of CCEPs see [16,17].…”

Section: μEcog Electrode Array Implant and Implantation Proceduresmentioning

confidence: 99%

Closed-loop interaction with the cerebral cortex using a novel micro-ECoG-based implant: the impact of beta vs. gamma stimulation frequencies on cortico-cortical spectral responses

Gkogkidis

Wang

Schubert

et al. 2017

Brain-Computer Interfaces

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(2017) Closed-loop interaction with the cerebral cortex using a novel micro-ECoG-based implant: the impact of beta vs. gamma stimulation frequencies on cortico-cortical spectral responses, 4:4,[214][215][216][217][218][219][220][221][222][223][224] Cemt, experimental surgery, medical Center, faculty of medicine, university of freiburg, freiburg, Germany ABSTRACT Medical brain implants for closed-loop interaction with the cerebral cortex promise new treatment options for brain disorders, and thus great efforts are being made to develop devices for long-term application. Closed-loop interaction can be implemented using electrophysiological recording techniques, and can be used to modulate local cortical activity or long-range functional connectivity. In a case study performed in sheep chronically implanted with a novel micro-electrocorticographybased device, we show that (1) open-loop single-pulse electrical stimulation (SPES) elicited the well-known cortico-cortical evoked potentials (CCEPs), and (2) closed-loop repetitive-pulse electrical stimulation (RPES) elicited specific cortico-cortical spectral responses (CCSRs). CCSRs were spatially focalized in the gamma band, compared with beta band independent of RPES frequency. The topography of CCSRs was different compared with CCEPs, suggesting that CCEPs and CCSRs capture different aspects of cortico-cortical connectivity. We propose that CCSRs provide new useful measures of functional connectivity, and that in particular gamma-band CCSRs may be an optimal choice if spatially precise closed-loop interaction is desired. However, the parameter space of microelectrocorticography stimulation patterns and associated changes in μECoG frequency bands needs to be further explored and many questions remain before closed-loop brain implants can be used in clinical applications.

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Parieto‐frontal network in humans studied by cortico‐cortical evoked potential

Cited by 119 publications

References 94 publications

Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy

Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy

Gamma activity modulated by naming of ambiguous and unambiguous images: Intracranial recording

Closed-loop interaction with the cerebral cortex using a novel micro-ECoG-based implant: the impact of beta vs. gamma stimulation frequencies on cortico-cortical spectral responses

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