Parity and diabetes mellitus.

Middleton, G. D.; Caird, F. I.

doi:10.1136/jech.22.2.100

Cited by 10 publications

(7 citation statements)

References 11 publications

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“…In contrast to others [22,23,24,25,26] we did not find a relationship between the incidence of diabetes in the offspring and their age, parity or course of pregnancy. However, our test subjects may still be too young or our group too small.…”

Section: Discussioncontrasting

confidence: 99%

The incidence of diabetes mellitus in the offspring of diabetic couples investigation based on the oral glucose tolerance test

Radder

Terpstra

1975

Diabetologia

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Summary. 88 of 137 offspring of 22 adult onset diabetic couples were subjected to an oral glucose tolerance test (G.T.T.); 35 were found to have a diabetic G.T.T. As 8 were already known as diabetics, 43 of 96 offspring (45Yo) were found to have diabetes mellitus. Neither the data pertaining to the parents, such as family history, treatment of diabetes or obstetric history, nor the data pertaining to the offspring, such as sex, age, parity or course of pregnancy, could be related to the incidence of diabetes in the offspring. It was noted however, that overweight female, but not male, offspring are more likely to develop diabetes than those who are not overweight (p < 0.05).

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Section: Discussioncontrasting

confidence: 99%

The incidence of diabetes mellitus in the offspring of diabetic couples investigation based on the oral glucose tolerance test

Radder

Terpstra

1975

Diabetologia

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“…We also examined studies that presented RR of type 2 diabetes per live birth in original papers in linear dose-response analysis (12,34,35,37,38,40,41,42); the pooled RR was attenuated to 1.04 (95% CI: 0.99-1.08). Additionally, the summary RR of type 2 diabetes was 1.06 (95% CI: 1.03-1.10) per live birth after including studies (31,32,33,42) for which crude estimates could be derived, and the shape of the nonlinear association between parity and type 2 diabetes was similar to the previous one. Overall, the sensitivity analyses did not lead to any significant changes on the association between parity and type 2 diabetes risk.…”

Section: Highest Vs Lowest Number Of Paritymentioning

confidence: 56%

MECHANISMS IN ENDOCRINOLOGY: Parity and risk of type 2 diabetes: a systematic review and dose-response meta-analysis

Shan

Zhou

et al. 2016

European Journal of Endocrinology

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Objective: Epidemiologic studies regarding the association between parity and risk of type 2 diabetes have yielded inconsistent results. Therefore, we performed a systematic review and dose-response meta-analysis to determine the relation between parity and type 2 diabetes risk. Methods: We searched PubMed and Embase for published epidemiologic studies that assessed the relation between parity and risk of type 2 diabetes up to 31 March 2016. A dose-response random-effects model was used to combine study-specific relative risks (RRs) and 95% confidence intervals (CIs). Potential sources of heterogeneity were explored by meta-regression and subgroup analyses. Results: Seven cohort studies, 1 case-control study and 9 cross-sectional studies including 296 923 participants were eligible for inclusion. The combined RR for the highest versus lowest category of parity indicated a 54% increment in type 2 diabetes risk (95% CI: 29-83%). In the cubic spline model, a nonlinear association was found between parity and risk of type 2 diabetes (P = 0.02 for nonlinearity). Compared with nulliparous women, the estimated RR (95% CI) of type 2 diabetes for women with one to seven children was 1.01 (0

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“…When adequate adjustment was made for age and obesity together or age or obesity alone, no study found no association. With inadequate adjustment for age or obesity, 9 studies found higher parity or gravidity in diabetic subjects or a higher diabetes prevalence in more parous or gravid women (16)(17)(18)(19)(20)(21)(22)(23)(24). With adequate adjustment for age and obesity together, 2 studies found higher parity or gravidity in diabetic women or higher diabetes prevalence in more parous or gravid women (1,2).…”

mentioning

confidence: 99%

Effects of Childbearing on Glucose Tolerance and NIDDM Prevalence

Boyko

Alderman²,

Keane³

et al. 1990

Diabetes Care

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The goal of this study was to estimate the effects of childbearing on subsequent glucose tolerance and non-insulin-dependent diabetes mellitus (NIDDM) prevalence. A sample of subjects from 64 different locations in the United States were recruited for inclusion in the Second National Health and Nutrition Examination Survey. A complex survey design was used to select a probability sample of subjects from each location. A total of 4577 women were recruited, of whom 3057 underwent clinical and laboratory evaluation for the presence of diabetes mellitus. Women were classified as to their glucose tolerance based on the results of an oral glucose tolerance test or previous physician diagnosis of diabetes mellitus combined with current use of hypoglycemic medication. Childbearing was defined as number of live births experienced by each woman at the time of the interview. Fasting plasma glucose increased linearly with increasing number of live births (coefficient 0.009, 95% confidence interval [CI] 0.006-0.012), as did the 2-h value (coefficient 0.015, 95% CI 0.009-0.021). Adjustment for age, body mass index (BMI), education, and income substantially reduced the magnitude of the association between childbearing and either plasma glucose measurement. When the prevalence of NIDDM in relation to childbearing was examined with logistic regression analysis, a significant linear increase in diabetes prevalence was seen with increasing number of live births (relative prevalence of NIDDM, 1 birth vs. 0 = 1.73, 95% CI 1.39-2.15), but adjustment for age, BMI, education, and income greatly reduced the magnitude of this association (relative prevalence of NIDDM, 1 birth vs. 0 = 1.07, 95% CI 0.98-1.17).(ABSTRACT TRUNCATED AT 250 WORDS)

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Parity and diabetes mellitus.

Cited by 10 publications

References 11 publications

The incidence of diabetes mellitus in the offspring of diabetic couples investigation based on the oral glucose tolerance test

The incidence of diabetes mellitus in the offspring of diabetic couples investigation based on the oral glucose tolerance test

MECHANISMS IN ENDOCRINOLOGY: Parity and risk of type 2 diabetes: a systematic review and dose-response meta-analysis

Effects of Childbearing on Glucose Tolerance and NIDDM Prevalence

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