Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis

Somasundara, Amritha Varshini Hanasoge; Moss, Matthew; Feigman, Mary J.; Chen, Chen; Cyrill, Samantha L.; Ciccone, Michael F.; Trousdell, Marygrace C.; Vollbrecht, Macy; Li, Siran; Kendall, Jude; Beyaz, Semir; Wilkinson, John E.; Santos, Camila O. dos

doi:10.1016/j.celrep.2021.110099

Cited by 19 publications

(13 citation statements)

References 96 publications

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“…There was evidence depicting that high BMI was associated with hay fever or other allergy diseases 35,36 . In previous studies, females with a history of pregnancy were identified to have decreased risk of endometrial cancer due to a fecundity effect, and the number of pregnancies is a proxy for a woman's ability to become pregnant, and thereby a healthy endometrium and endocrine system 37 . In our study, females with pregnancy history had higher risk of allergy, hay fever, and dog‐specific IgE, this might due to that the maternal immune system underwent major adaptive modifications during pregnancy and pregnancy history might change the immune microenvironment of women, 38,39 and thus the association between endometriosis and allergy, hay fever, and dog‐specific IgE was significant.…”

Section: Discussionmentioning

confidence: 99%

Associations between endometriosis and allergy‐related diseases as well as different specific immunoglobulin E allergy: A cross‐sectional study

Chen

Liu

2022

J of Obstet and Gynaecol

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Aim To explore the associations between endometriosis and different kinds of allergy‐related diseases as well as different specific immunoglobulin E (IgE) allergy. Methods This cross‐sectional study included 1332 female participants ≥20 years and divided them into the endometriosis group (n = 97) and the nonendometriosis group (n = 1235). The confounders were obtained by comparing the differences of variables in groups. Univariate and multivariate logistic regression analyses were performed to analyze the associations between endometriosis and allergy‐related diseases as well as different specific IgE allergy. Subgroup analysis were performed in age, body mass index (BMI), and pregnancy history. Results After adjusting for confounders, increased risk of allergy (odd ratios [OR] = 2.13, 95% confidence interval [CI]: 1.31–3.47), hay fever (OR = 2.31, 95%CI: 1.32–4.06), and dog‐specific IgE (OR = 2.13, 95%CI: 1.03–4.41) were observed in females with endometriosis. Among females aged between 30 and 39 years, the risk of allergy (OR = 3.51, 95%CI: 1.07–11.56), hay fever (OR = 3.26, 95%CI: 1.08–9.83), and dog‐specific IgE (OR = 4.39, 95%CI: 1.02–18.88) was increased in patients with endometriosis compared with those without. In terms of females aged 40 to 49 years, the risk of hay fever was increased in patients with endometriosis. For females with BMI of 25–30 kg/m2, the risk of allergy was increased in patients with endometriosis. Increased risk of allergy, hay fever, and dog‐specific IgE was observed in females with a history of pregnancy. Conclusion Endometriosis was associated with higher risk of allergy, hay fever, and dog dander. Special care should be provided for patients with endometriosis for the potential risk of allergy.

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Section: Discussionmentioning

confidence: 99%

Associations between endometriosis and allergy‐related diseases as well as different specific immunoglobulin E allergy: A cross‐sectional study

Chen

Liu

2022

J of Obstet and Gynaecol

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“…Multiple animal models of mammary tumorigenesis and pregnancy have confirmed the protective effects of pregnancy in BC (Feigman et al, 2020;Hanasoge Somasundara et al, 2021). Interestingly, prolonged lactation and nursing have also been identified as key risk factors for inflammatory breast cancer (IBC), a rare and highly aggressive BC subtype (Mejri et al, 2020).…”

Section: Loss Of Irf5 Expression Alters Normal Mammary Gland Developm...mentioning

confidence: 99%

Loss ofIRF5increases ribosome biogenesis leading to alterations in mammary gland architecture and metastasis

Brune

et al. 2023

Preprint

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Despite the progress made in identifying cellular factors and mechanisms that predict progression and metastasis, breast cancer remains the second leading cause of death for women in the US. Using The Cancer Genome Atlas and mouse models of spontaneous and invasive mammary tumorigenesis, we identified that loss of function of interferon regulatory factor 5 (IRF5) is a predictor of metastasis and survival. Histologic analysis of Irf5-/- mammary glands revealed expansion of luminal and myoepithelial cells, loss of organized glandular structure, and altered terminal end budding and migration. RNA-seq and ChIP-seq analyses of primary mammary epithelial cells from Irf5+/+ and Irf5-/- littermate mice revealed IRF5-mediated transcriptional regulation of proteins involved in ribosomal biogenesis. Using an invasive model of breast cancer lacking Irf5, we demonstrate that IRF5 re-expression inhibits tumor growth and metastasis via increased trafficking of tumor infiltrating lymphocytes and altered tumor cell protein synthesis. These findings uncover a new function for IRF5 in the regulation of mammary tumorigenesis and metastasis.

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“…24,59 Given that pregnancy is one of the most important life history factors that modulates BC, such studies may allow for the identification of mechanisms and pathways that support the development of strategies for BC prevention. [60][61][62] Moreover, similar organoid systems could support the study and characterization of BC tissue obtained from pregnant women, thus enabling the investigation of cancer-associated mechanisms ex vivo that were present during in vivo development.…”

Section: Normal and Neoplastic Breast Systemsmentioning

confidence: 99%

Clinical applications of 3D normal and breast cancer organoids: A review of concepts and methods

Lewis

Callaway

Santos

2022

Exp Biol Med (Maywood)

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While mouse models and two-dimensional (2D) cell culture systems have dominated as research tools for cancer biology, three-dimensional (3D) cultures have gained traction as a new approach that retains features of in vivo biology within an in vitro system. Over time, 3D culture systems have evolved from spheroids and tumorspheres to organoids, and by doing so, they have become more complex and representative of original tissue. Such technological improvements have mostly benefited the study of heterogeneous solid tumors, like those found in breast cancer (BC), by providing an attractive avenue for scalable drug testing and biobank generation. Experimentally, organoids have been used in the BC field to dissect mechanisms related to cellular invasion and metastasis—and through co-culture methods—epithelial interactions with stromal and immune cells. In addition, organoid studies of wild-type mouse models and healthy donor samples have provided insight into the basic developmental cellular and molecular biology of the mammary gland, which may inform one’s understanding of the initial stages of cancer development and progression.

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Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis

Cited by 19 publications

References 96 publications

Associations between endometriosis and allergy‐related diseases as well as different specific immunoglobulin E allergy: A cross‐sectional study

Associations between endometriosis and allergy‐related diseases as well as different specific immunoglobulin E allergy: A cross‐sectional study

Loss ofIRF5increases ribosome biogenesis leading to alterations in mammary gland architecture and metastasis

Clinical applications of 3D normal and breast cancer organoids: A review of concepts and methods

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