PARK7/DJ-1 as a Therapeutic Target in Gut-Brain Axis Diseases

Pap, Domonkos; Veres-Székely, Apor; Szebeni, Beáta; Vannay, Ádám

doi:10.3390/ijms23126626

Cited by 12 publications

(9 citation statements)

References 158 publications

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“…DJ-1-deficient microglia leads to a further increase in inflammatory cytokine release. Thus, abnormal DJ-1 function leads to accelerated disease progression in Parkinson's disease (Sliter et al, 2018;Neves et al, 2022;Pap et al, 2022; Figure 2).…”

Section: Microglia and Parkinson's Diseasementioning

confidence: 99%

New insight on microglia activation in neurodegenerative diseases and therapeutics

Xu,

Gao,

Sun

et al. 2023

Front. Neurosci.

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Microglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. In response to changes in the surrounding environment, microglia activate and change their state and function. Several factors, example for circadian rhythm disruption and the development of neurodegenerative diseases, influence microglia activation. In this review, we explore microglia’s function and the associated neural mechanisms. We elucidate that circadian rhythms are essential factors influencing microglia activation and function. Circadian rhythm disruption affects microglia activation and, consequently, neurodegenerative diseases. In addition, we found that abnormal microglia activation is a common feature of neurodegenerative diseases and an essential factor of disease development. Here we highlight the importance of microglia activation in neurodegenerative diseases. Targeting microglia for neurodegenerative disease treatment is a promising direction. We introduce the progress of methods targeting microglia for the treatment of neurodegenerative diseases and summarize the progress of drugs developed with microglia as targets, hoping to provide new ideas for treating neurodegenerative diseases.

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Section: Microglia and Parkinson's Diseasementioning

confidence: 99%

New insight on microglia activation in neurodegenerative diseases and therapeutics

Xu,

Gao,

Sun

et al. 2023

Front. Neurosci.

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“…These small-molecule drugs can be future divided into two categories, based on their potency in targeting DJ-1’s enzymatic/catalytic activities and/or non-enzymatic activities (that is to say, structural activities). Overall, the pharmaceutical or genetic activation/suppression of DJ-1 in combination with other therapies (such as immuno-oncology) will open up new avenues for the treatment of various intractable human diseases other than cancer and PD (such as gut–brain axis diseases and ischemia–reperfusion injury) [ 87 , 88 ].…”

Section: Outlook and Perspectivesmentioning

confidence: 99%

The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research

Sun

Zheng

2023

IJMS

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DJ-1 (also known as PARK7) is a multifunctional enzyme in human beings that is highly conserved and that has also been discovered in diverse species (ranging from prokaryotes to eukaryotes). Its complex enzymatic and non-enzymatic activities (such as anti-oxidation, anti-glycation, and protein quality control), as well as its role as a transcriptional coactivator, enable DJ-1 to serve as an essential regulator in multiple cellular processes (e.g., epigenetic regulations) and make it a promising therapeutic target for diverse diseases (especially cancer and Parkinson’s disease). Due to its nature as a Swiss army knife enzyme with various functions, DJ-1 has attracted a large amount of research interest, from different perspectives. In this review, we give a brief summary of the recent advances with respect to DJ-1 research in biomedicine and psychology, as well as the progress made in attempts to develop DJ-1 into a druggable target for therapy.

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“…With the deepening of study, it has been found that PARK7/DJ-1 can regulate almost all neuroinflammatory diseases. According to the experimental data, PARK7/DJ-1 alleviates the condition of AD by reducing the activity of glyoxalase activity and reducing the harmful effects on neurons ( Pap et al., 2022 ). It is reported that the decrease in the expression of PARK7/DJ-1 induces an inflammatory response in colon cancer cells, indicating its anti-inflammatory effect ( Lippai et al., 2021 ).…”

Section: Innate Immune Signaling Pathway Regulates Inflammatory and I...mentioning

confidence: 99%

“…It is reported that the decrease in the expression of PARK7/DJ-1 induces an inflammatory response in colon cancer cells, indicating its anti-inflammatory effect ( Lippai et al., 2021 ). Similarly, PARK7/DJ-1 affects the local and systemic inflammatory characteristics of IBD by maintaining gut microbiome and mucosal integrity ( Pap et al., 2022 ). In addition, through the proteomics detection of the plasma of IBD patients, it was found that the PARK7/DJ-1 protein in plasma increased ( Di Narzo et al., 2019 ).…”

Section: Innate Immune Signaling Pathway Regulates Inflammatory and I...mentioning

confidence: 99%

Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases

Yuan,

He,

Xie

et al. 2023

Front. Cell. Infect. Microbiol.

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The microbiota gut brain (MGB) axis has been shown to play a significant role in the regulation of inflammatory and infective diseases. Exploring the structure and communication mode of MGB axis is crucial for understanding its role in diseases, and studying the signaling pathways and regulatory methods of MGB axis regulation in diseases is also of profound significance for future clinical research. This article reviews the composition, communication mechanism of MGB axis and its role in inflammatory and infective diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), multiple sclerosis (MS), autism spectrum disorder (ASD), depression, psoriasis, irritable bowel syndrome (IBS), and inflammatory bowel diseases (IBD). In addition, our investigation delved into the regulatory functions of the inflammasome, IFN-I, NF-κB, and PARK7/DJ-1 innate immune signaling pathway in the context of inflammatory and infective diseases. Ultimately, we discussed the efficacy of various interventions, including fecal microbiota transplantation (FMT), antibiotics, probiotics, prebiotics, synbiotics, and postbiotics, in the management of inflammatory and infective diseases. Understanding the role and mechanism of the MGB axis might make positive effects in the treatment of inflammatory and infective diseases.

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PARK7/DJ-1 as a Therapeutic Target in Gut-Brain Axis Diseases

Cited by 12 publications

References 158 publications

New insight on microglia activation in neurodegenerative diseases and therapeutics

New insight on microglia activation in neurodegenerative diseases and therapeutics

The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research

Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases

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