Biocomputing 2021 2020
DOI: 10.1142/9789811232701_0019
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ParKCa: Causal Inference with Partially Known Causes

Abstract: Causal Inference methods based on observational data are an alternative for applications where collecting the counterfactual data or realizing a more standard experiment is not possible. In this work, our goal is to combine several observational causal inference methods to learn new causes in applications where some causes are well known. We validate the proposed method on The Cancer Genome Atlas (TCGA) dataset to identify genes that potentially cause metastasis.

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“…We adopted the three datasets to validate our proposed method. Please check our Appendix for an extended description of the datasets: GWAS [22,1]: The Genome-Wide Association Study (GWAS) dataset is a semi-simulated dataset that explores sparse settings. Proposed initially to handle multiple treatments, we adapt it to have one binary treatment T and a continuous outcome Y .…”
Section: Datasetsmentioning
confidence: 99%
“…We adopted the three datasets to validate our proposed method. Please check our Appendix for an extended description of the datasets: GWAS [22,1]: The Genome-Wide Association Study (GWAS) dataset is a semi-simulated dataset that explores sparse settings. Proposed initially to handle multiple treatments, we adapt it to have one binary treatment T and a continuous outcome Y .…”
Section: Datasetsmentioning
confidence: 99%