2017
DOI: 10.1038/nrdp.2017.13
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Parkinson disease

Abstract: Parkinson disease is the second-most common neurodegenerative disorder that affects 2-3% of the population ≥65 years of age. Neuronal loss in the substantia nigra, which causes striatal dopamine deficiency, and intracellular inclusions containing aggregates of α-synuclein are the neuropathological hallmarks of Parkinson disease. Multiple other cell types throughout the central and peripheral autonomic nervous system are also involved, probably from early disease onwards. Although clinical diagnosis relies on t… Show more

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Cited by 3,771 publications
(3,360 citation statements)
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“…Experimental therapies have tried to restore striatal dopamine in PD patients by gene-based and cell-based approaches. Aside from ethical considerations and logistic challenges, data concerning the use of human fetal ventral mesencephalic allografts in PD are controversial (24,25).…”
Section: Treatment and Prognosismentioning
confidence: 99%
“…Experimental therapies have tried to restore striatal dopamine in PD patients by gene-based and cell-based approaches. Aside from ethical considerations and logistic challenges, data concerning the use of human fetal ventral mesencephalic allografts in PD are controversial (24,25).…”
Section: Treatment and Prognosismentioning
confidence: 99%
“…Of these, Parkinson's disease (PD) is characterised by the accumulation of a misfolded and aggregated protein called α‐synuclein within neurons to form Lewy neurites and Lewy bodies 3. Genetic and pathological evidence suggests that the protein α‐synuclein is central to neurodegeneration in PD 4. Specifically, the transition from an intrinsically disordered α‐synuclein monomer through a series of oligomeric intermediates (with varying structures and size) to a highly structured filament5, 6 is recognised to drive pathogenesis in α‐synucleinopathies.…”
mentioning
confidence: 99%
“…LBs are considered to be the markers for neuronal degeneration, as neuronal loss is associated with sites rich in LBs [192]. Impairments in different cognitive domains such as language, memory, executive functions, and visio-spatial skills have been reported in the Review Amarendranath Choudhury early stages of PD [193]. Though the clinical diagnosis of PD relies on bradykinesia and motor functions, many non-motor symptoms also append the overall disease load [194].…”
Section: Parkinson's Disease and Related Psychobehavioural Anomaliesmentioning
confidence: 99%