Parkinson et Gougerot-Sjögren

Essaadouni, L.; Muller, G.; Vinit, J.; Ornetti, Paul; Bielefeld, P.; Besancenot, J.F.

doi:10.1016/s0248-8663(03)80241-2

Cited by 2 publications

(3 citation statements)

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“…To the best of our knowledge, only 14 similar cases have been reported since the first publication of Visser and collaborators in 1993 [3]. Afterward, this association has been reported in isolated cases ([4–6, 8–11]; Table 1). Walker et al in 1999 and Hassin-Baer et al in 2007 described 3 cases, respectively [7, 12].…”

Section: Discussionmentioning

confidence: 99%

“…It precedes the systemic signs in 8/15 cases. Women are more commonly subject to Parkinsonism, with an average age of 61 years, and are often dopa-resistant [ 4 , 7 , 9 , 11 ]. In most cases, brain MRI shows hyperintensity on T2 and FLAIR in the white matter, in the striatum, or in the globus pallidus [ 3 , 5 – 7 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…An exhaustive bibliographic search allows the identification of only 14 cases describing Parkinsonism associated with pSS published to date [ 3 – 12 ]. In these cases, direct accountability of SS was most often suggested by clinical, radiological data and treatment response [ 9 – 11 ]. This study reports a new case of “Parkinsonism and SS” association and discusses two hypotheses for this relation: Is there really a common anatomical basis between these two syndromes as suggested by the majority of authors?…”

Section: Introductionmentioning

confidence: 99%

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Parkinsonism and Sjögren’s Syndrome: A Fortuitous Association or a Shared Immunopathogenesis?

Kchaou

Ali

Hmida

et al. 2015

Case Reports in Medicine

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Background. The Sjögren Syndrome (SS) can include various manifestations of central nervous system impairment. Extrapyramidal signs are known to be very rare and unusually discovered on early onset in this pathology. Observation. A 46-year-old woman with a history of progressive Parkinsonism for 6 years and a normal brain magnetic resonance imaging was partially improved with levodopa therapy. The later discovery of a sicca syndrome led to performing of further investigations, which revealed the presence of anti-SSA antibodies and a sialoadenitis of grade 4 according to Chisholm's classification on labial salivary gland biopsy. The diagnosis of primary SS was established and the adjunction of corticotherapy has remarkably improved Parkinson's signs without use of other immunosuppressive agents. Conclusion. Based on these findings, we discuss the hypothesis of either a causal link between SS and Parkinsonism or a fortuitous association of two distinct pathologies with or without a shared immunopathogenesis.

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