Parkinson's disease and cardiovascular involvement: Edifying insights (Review)

Grosu, L; Grosu, Alin; Crişan, Dana; Zlibut, Alexandru; Perju‐Dumbravă, Lăcrămioara

doi:10.3892/br.2023.1607

Cited by 14 publications

(4 citation statements)

References 90 publications

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“…[ 16 ] A review of ECGs shows that QTC prolongation was significantly higher in non-survivor PD cases than in a control group. [ 17 ] In this research, we found that QT and QTc parameters were appreciably prolonged in the PD group than in the control group. QT and QTc parameters were positively correlated with Modified YHS.…”

Section: Discussionmentioning

confidence: 58%

Index of cardio-electrophysiological balance and Parkinson disease

Ozturk,

Ozturk

2023

Medicine

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Neurodegeneration of the autonomic nervous systems due to Parkinson disease (PD) may lead to increase in the QT duration. In recent years, a new parameter index of cardio-electrophysiological balance (ICEB) was found. ICEB is a significant parameter of medicine related dysrhythmia. The purpose of this research is to assess ICEB in PD. Twenty-eight PD cases and 26 controls participated in our investigation. First diagnosed PD patients were registered in the research. The symptom progression of PD was assessed Modified Hoehn and Yahr Scale. Analyzed ECG variables are QRS, PR, QT, corrected QT (QTc) interval, ICEB and corrected index of cardio-electrophysiological balance (ICEBc). All cases had sinus rhythm. ICEB was analyzed by the ratio of QT/QRS. ICEBc was analyzed by the ratio of QTc/QRS. Twenty-eight PD cases participated in this research. Among PD cases, 15 patients were female (53.5%). The mean age of PD patients are 59.03 ± 9.94 years. There was no important difference between groups with respect to the clinical variables. The Modified Hoehn and Yahr Scale was appreciably higher in the PD group than the Control group. The heart rate of the PD group was significantly lower than that of the control group. PR intervals and QRS duration were similar in both groups. QT and QTc duration were significantly longer in PD patients. Also, the ICEB and ICEBc variables were appreciably higher in PD cases. The findings of our investigation suggest that ICEB is related to PD. ICEB can help to evaluate arrhythmia risk in patients with PD.

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Section: Discussionmentioning

confidence: 58%

Index of cardio-electrophysiological balance and Parkinson disease

Ozturk,

Ozturk

2023

Medicine

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“…Our results suggest that underlying cardiovascular problems could be a risk factor for developing iPD, especially in males. This could be attributed to common disease-associated risk factors between CVD and PD, chronic inflammation because of the underlying cardiac problems or due to CVD induced vascular damage leading to reduced blood flow to the brain causing the neuronal death [ 29 , 30 ]. Therefore, CVD history as a risk and sex-specific differences must be taken into account when assessing patients with suspected iPD and developing preventive measures.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular history and risk of idiopathic Parkinson’s disease: a cross-sectional observational study

Acharya,

Lumley,

Devaux

et al. 2024

BMC Neurosci

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Background Parkinson's disease (PD), while often associated with its distinctive motor symptoms, can also exert a notable impact on the cardiovascular system due to the development of severe autonomic dysfunction. One of the initial indicators of PD is the appearance of cardiovascular dysautonomia. As such, it is vital to monitor and manage cardiovascular health of individuals with PD, as it may have clinical implications in the development of commonly recognized motor and non-motor aspects of the disease. To study the association of history of cardiovascular disease (CVD) with occurrence and severity of PD, here, we lend data on the association of CVD history with the frequency and the occurrence of idiopathic PD (iPD) using data from the Luxembourg Parkinson’s study (iPD n = 676 patients and non-PD n = 874 controls). Results We report that patients with a history of CVD are at high risk of developing iPD (odds ratio; OR = 1.56, 95% confidence interval; CI 1.09–2.08). This risk is stronger in males and remains significant after adjustment with confounders (OR 1.55, 95% CI 1.05–2.30). This increased susceptibility to iPD is linked to the severity of iPD symptoms mainly the non-motor symptoms of daily living (MDS-UPDRS I) and motor complications (MDS-UPDRS IV) in the affected individuals. Conclusion Individuals with history of CVD have a high risk of developing severe forms of iPD. This observation suggests that careful monitoring and management of patients with a history of cardiac problems may reduce the burden of iPD.

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“…This temporal response of symptoms to DBS can be related to a number of factors including the change in medications after surgery and the underlying disease progression. Indeed, levodopa and dopaminergic medications in general are known to have an effect on cardiovascular functions in PD [ 57 ], with higher doses having a more detrimental effect than lower doses [ 58 ]. The reported short-term improvement in cardiovascular symptoms after DBS may reflect the decrease in total levodopa equivalent daily dose (46.9% reduction in the included studies), however only scanty data are available and there is no control for this variable in the vast majority of the studies.…”

Section: Discussionmentioning

confidence: 99%

Short term cardiovascular symptoms improvement after deep brain stimulation in patients with Parkinson's disease: a systematic review

Cucinotta,

Swinnen,

Makovac

et al. 2024

J Neurol

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Background Autonomic dysfunction is common and disabling in Parkinson's disease (PD). The effects of deep brain stimulation (DBS) on the cardiovascular system in PD remain poorly understood. We aimed to assess the effect of DBS on cardiovascular symptoms and objective measures in PD patients. Methods We conducted a systematic literature search in PubMed/MEDLINE. Results 36 out of 472 studies were included, mostly involving DBS of the subthalamic nucleus, and to a lesser extent the globus pallidus pars interna and pedunculopontine nucleus. Seventeen studies evaluated the effect of DBS on patient-reported or clinician-rated cardiovascular symptoms, showing an improvement in the first year after surgery but not with longer-term follow-up. DBS has no clear direct effects on blood pressure during an orthostatic challenge (n = 10 studies). DBS has inconsistent effects on heart rate variability (n = 10 studies). Conclusion Current evidence on the impact of DBS on cardiovascular functions in PD is inconclusive. DBS may offer short-term improvement of cardiovascular symptoms in PD, particularly orthostatic hypotension, which may be attributed to dopaminergic medication reduction after surgery. There is insufficient evidence to draw conclusions on the direct effect of DBS on blood pressure and heart rate variability.

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Parkinson's disease and cardiovascular involvement: Edifying insights (Review)

Cited by 14 publications

References 90 publications

Index of cardio-electrophysiological balance and Parkinson disease

Index of cardio-electrophysiological balance and Parkinson disease

Cardiovascular history and risk of idiopathic Parkinson’s disease: a cross-sectional observational study

Short term cardiovascular symptoms improvement after deep brain stimulation in patients with Parkinson's disease: a systematic review

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