Parkinson’s Disease and Cognitive Impairment

Yang, Yang; Tang, Beisha; Guo, Jifeng

doi:10.1155/2016/6734678

Cited by 55 publications

(45 citation statements)

References 123 publications

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“…As we all know, seizures have long been considered as a complication of AD, ischemic stroke and other neurological diseases (Camilo & Goldstein, 2004;Larner, 2010). In addition, PD, schizophrenia, and cerebral infarction appear to be primarily associated with cognitive dysfunction (Bennett, Schneider, Bienias, Evans, & Wilson, 2005;Green, 2006;Y. Yang, Tang, & Guo, 2016).…”

Section: Discussionmentioning

confidence: 99%

Lapatinib protects against epileptic seizures via halting glutathione peroxidase 4-dependent ferroptosis

Jia

Sun

et al. 2020

Preprint

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Background and PurposeRepetitive epileptic seizures trigger massive neuronal death. Therefore, neuroprotection plays a role in preventing neuronal death and inversely suppresses seizure generation. Additionally, some studies have shown ferroptosis, featured by lipid peroxidation (a dominant form of oxidative stress in the brain), is of paramount importance in epileptic seizures. Lapatinib can play a first-line anti-tumor role by targeting oxidative stress and a recent work illustrates the improvement of encephalomyelitis in rodent models after lapatinib treatment. We hypothesize whether lapatinib can protect against ferroptosis in epileptic seizures via regulating lipid peroxidation.Experimental ApproachThe epileptic behavior of the mice was recorded after intracranial injection of KA. Western blot and RT-qPCR were used to detect the protein expression of 4-hydroxynonenal (4-HNE) and glutathione peroxidase 4 (GPX4) and the mRNA expression of prostaglandin endoperoxide synthase 2 (PTGS2) in vivo and in vitro. The level of lipid reactive oxygen species (lipid ROS) in cells pretreated with lapatinib was analyzed by flow cytometry.Key ResultsLapatinib remarkably prevented KA-induced epileptic seizures in mice and ferroptosis was involved in the neuroprotection of lapatinib. Compared with the model group, western blot showed that lapatinib significantly upregulated the levels of GPX4. In the ferroptotic cell death model, lapatinib exerted neuroprotection via up-regulating GPX4. Treatment with Ras-selective lethal small molecule 3 (RSL3), a selective GPX4 inhibitor abrogated its anti-ferroptotic potential.Conclusions and ImplicationsThese results illustrated that lapatinib has neuroprotective potential against KA-triggered epileptic seizures via suppressing GPX4-dependent ferroptosis.What is already knownActivation of ferroptosis occurs in epileptic seizures.What this study addsLapatinib protects brain against epileptic seizures via blocking ferroptosis.GPX4-dependent ferroptosis is involved in the neuroprotection of lapatinib.What is the clinical significanceInhibition of ferroptosis by lapatinib represents a potential neuroprotective strategy for epileptic patients.

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Section: Discussionmentioning

confidence: 99%

Lapatinib protects against epileptic seizures via halting glutathione peroxidase 4-dependent ferroptosis

Jia

Sun

et al. 2020

Preprint

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“…La Enfermedad de Parkinson (EP) o parkinsonismo, es una patología neurodegenerativa, progresiva e incurable. Actualmente su etiopatogenia sigue siendo parcialmente conocida debido al carácter multifactorial (ambientales, genéticos y de envejecimiento, etc.,) que posee (Yang, Bei-sha y Ji-feng, 2016). Principalmente esta enfermedad se caracteriza por la presencia de 4 síntomas cardinales, entre los cuales están: temblor, rigidez, bradisinecia/acinesia, e inestabilidad postural.…”

Section: Generalidades Del Parkinsonunclassified

“…La frecuencia es de 4 a 6 Hz y de 5 a 8 Hz, respectivamente (Cudeiro Mazaira, 2015). Su topografía más frecuente es en manos, brazos, cabeza, tronco, mandíbula, labios y lengua (Yang, Bei-sha y Ji-feng, 2016). En extremidades superiores, el temblor en reposo afecta a la flexión-extensión de los dedos, pronación-supinación del antebrazo y a la flexión-extensión en la articulación del codo (Jankovic y Tolosa, 2007).…”

Section: Estadio IVunclassified

Dispositivo mecatrónico para el análisis y mitigación de movimientos involuntarios en personas con enfermedad de Parkinson

Cárdenas¹,

Bonilla²,

Moya³

et al. 2019

Enfoque UTE

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La enfermedad de Parkinson (EP) es una patología neurodegenerativa, progresiva e incurable; con el fin de mejorar la calidad de vida de las personas que la padecen, se propuso el diseño y construcción de un dispositivo mecatrónico que permita el análisis de los movimientos involuntarios producto de la enfermedad. Dicho dispositivo permite, mediante el uso señales electromiográficas producidas por los músculos del antebrazo y de un algoritmo basado en redes neuronales artificiales, el análisis de los movimientos involuntarios de pronosupinación generados en las extremidades superiores. Para la materialización del dispositivo se tomó en cuenta técnicas de prototipado rápido como lo es la impresión 3D y el modelo en V aplicado a la Mecatrónica. Como resultado de este trabajo de investigación se obtuvo un dispositivo mecatrónico en forma de exoesqueleto controlado por un sistema embebido que analiza y procesa señales electromiográficas y, mediante redes neuronales artificiales, permite la clasificación del temblor y de movimientos voluntarios producidos por cada paciente. Los resultados del funcionamiento del sistema son: para la predicción de temblor 96.88 % de acierto y para la predicción de movimiento voluntario 100 % de acierto.

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“…Parkinson's disease (PD) is the second most common neurodegenerative disease along with Alzheimer's disease [1,2]. The onset of PD is usually after the age of 50 and a sharp rise of the incidence occurs after the age of 60 [3].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Effects of Tolcapone a Catechol-O-Methyltransferase Inhibitor on Learning and Memory in Passive Avoidance Task

Bakova

Zlatanova

Doncheva

et al. 2019

JAMMR

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Aim: The aim of the present study was to evaluate the effects of tolcapone in haloperidolchallenged rodent models of learning and memory and reserpine-induced parkinsonism in rats. Methods: The learning and memory enhancing effects of tolcapone (TCP) were assessed in male Wistar rats treated with 5, 15 and 30 mg/kg bw, p.o. The impact of tolcapone on haloperidol challenge and reserpine induced parkinsonism was studied in rodents treated with 5,15 and 30 mg/kg bw TCP p.o. Step-through passive avoidance and loco-motor activity were assessed. The latency reaction time and the number of horizontal and vertical movements were registered, respectively. Statistical analysis was done by SPSS Statistics 19.

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Parkinson’s Disease and Cognitive Impairment

Cited by 55 publications

References 123 publications

Lapatinib protects against epileptic seizures via halting glutathione peroxidase 4-dependent ferroptosis

Lapatinib protects against epileptic seizures via halting glutathione peroxidase 4-dependent ferroptosis

Dispositivo mecatrónico para el análisis y mitigación de movimientos involuntarios en personas con enfermedad de Parkinson

Investigating the Effects of Tolcapone a Catechol-O-Methyltransferase Inhibitor on Learning and Memory in Passive Avoidance Task

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