Parkinson’s Disease and Diabetes Mellitus: Synergistic Effects on Pathophysiology and GI Motility

Yan, Yun; Shimoga, Dhanush; Sharma, Amol

doi:10.1007/s11894-023-00868-7

Cited by 4 publications

(12 citation statements)

References 78 publications

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“…However, the main mechanisms underlying SIBO pathogenesis are typical of the aging process, including a high prevalence of motility alterations or anatomical changes of the intestine (i.e. after surgery), adherences, diverticular disease, and immunological deficits [ 25 , 26 ▪▪ ]. Diabetes mellitus, Parkinson's disease, hypothyroidism, and depression are common conditions associated with advancing age that affect the autonomic nervous system, slowing the gastrointestinal transit and consequently increasing the probability to develop a SIBO condition.…”

Section: Differential Diagnosis Of Lactose Intolerance and Their Rela...mentioning

confidence: 99%

“…Diabetes mellitus, Parkinson's disease, hypothyroidism, and depression are common conditions associated with advancing age that affect the autonomic nervous system, slowing the gastrointestinal transit and consequently increasing the probability to develop a SIBO condition. As a matter of fact, about half of individuals with Parkinson's diseases has a diagnosis of SIBO [ 25 , 26 ▪▪ ].…”

Section: Differential Diagnosis Of Lactose Intolerance and Their Rela...mentioning

confidence: 99%

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Lactose malabsorption and intolerance in older adults

Gallo,

Marzetti,

Pellegrino

et al. 2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Lactose malabsorption and intolerance are very common conditions. However, their optimal approach, including the diagnostic assessment, remains a matter of debate, especially in advanced age. In this brief review, we focused on current knowledge, concerns, and impact in clinical practice of lactose malabsorption and intolerance in elderly. Recent findings Older adults are at high risk of malnutrition, owing to frequent occurrence of cognitive impairment, loss of appetite, dysphagia, and poor oral health. A significant decrease in the consumption of dairy products may lead to inadequate intake of high-quality protein and minerals, with a consequent impact on muscle and bone health. Testing for lactose malabsorption may be challenging in older adults, if not useless. Instead, a detailed clinical evaluation should always be pursued to identify both lactose intolerance and all confounding factors mimicking the same clinical picture. Summary The management of lactose malabsorption and intolerance in older adults deserves a personalized approach. Because of the importance of maintaining an adequate nutritional status in this age group, efforts should be put forth to avoid excessively restrictive diets.

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Section: Differential Diagnosis Of Lactose Intolerance and Their Rela...mentioning

confidence: 99%

Section: Differential Diagnosis Of Lactose Intolerance and Their Rela...mentioning

confidence: 99%

Lactose malabsorption and intolerance in older adults

Gallo,

Marzetti,

Pellegrino

et al. 2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

View full text Add to dashboard Cite

show abstract

“…Type 2 diabetes (T2D) and Parkinson's disease (PD) are chronic disorders that have a significant health impact on a global scale [1,2]. This narrative review aims to summarise the recent evidence on the contribution of T2D to PD aetiology.…”

Section: Introductionmentioning

confidence: 99%

“…Ageing is a primary risk factor and is sometimes described as a pre-PD condition [22][23][24]. Also, epidemiological, preclinical, and clinical data support the association of T2D with an increased risk or accelerated progression of PD signs and symptoms [1,2,[25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

The Contribution of Type 2 Diabetes to Parkinson’s Disease Aetiology

Ribarič

2024

IJMS

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Type 2 diabetes (T2D) and Parkinson’s disease (PD) are chronic disorders that have a significant health impact on a global scale. Epidemiological, preclinical, and clinical research underpins the assumption that insulin resistance and chronic inflammation contribute to the overlapping aetiologies of T2D and PD. This narrative review summarises the recent evidence on the contribution of T2D to the initiation and progression of PD brain pathology. It also briefly discusses the rationale and potential of alternative pharmacological interventions for PD treatment.

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“…These problems significantly contribute to reduction in quality of life in PD 2 . In clinical evaluation of PD patients, constipation severity can be underappreciated with a focus on bowel movement frequency, as opposed to bowel movement form, straining, sense complete evacuation, laxative use, and use of digital maneuvers for evacuation of stool 5 . The pathophysiology of constipation in PD is multidimensional with features of slow colonic transit, dyssynergic or disordered defecation, altered rectal sensation, or a combination of these features 6–9 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of bidirectional gut‐brain axis and anorectal function in Parkinson's disease with constipation

Yan,

Tennekoon,

Eubanks

et al. 2023

Neurogastroenterology Motil

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BackgroundParkinson's disease (PD) is a neurodegenerative movement disorder with prodromal and highly prevalent gastrointestinal (GI) symptoms, especially constipation. Although PD models suggest gut‐brain axis dysfunction, the mechanistic underpinnings and their correlation with GI symptoms are poorly understood.AimTo examine the bidirectional gut‐brain axis function in PD and correlate it with constipation severity, PD duration, and severity.MethodsRectal sensory thresholds and afferent cortical evoked potentials (CEP) were assessed using a 4‐ring EMG electrode probe. Efferent anal and rectal motor evoked potentials (MEPs) were obtained following transcranial and lumbosacral magnetic stimulation. Bowel symptoms were assessed by prospective stool diary. The CEP and MEP latencies, rectal sensory thresholds, and anorectal sensorimotor data were compared between PD subjects and age‐adjusted healthy subjects.Key ResultsTwenty‐five PD subjects with constipation (F/M = 6/19) and 20 healthy subjects (F/M = 14/6) were enrolled. The first and pain sensation thresholds were higher in PD subjects than healthy subjects (p < 0.002) but lost significance after adjustment for age. Age‐adjusted rectal CEP and right‐sided cortico‐anal MEP latencies were prolonged in PD subjects compared to healthy subjects (p < 0.04). Also, half (4 of 8) age‐adjusted spino‐anal and rectal MEP latencies in PD subjects were significantly longer. In multivariate linear analysis, first rectal sensation and right‐sided MEP latencies showed moderate correlation with constipation severity.Conclusions & InferencesParkinson's disease is associated with significant bidirectional gut‐brain axis dysfunction as evidenced by prolonged afferent and efferent neuronal signaling. Constipation severity in PD is correlated to abnormal rectal sensation and lateralized disturbance of efferent brain‐gut signaling.

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Parkinson’s Disease and Diabetes Mellitus: Synergistic Effects on Pathophysiology and GI Motility

Cited by 4 publications

References 78 publications

Lactose malabsorption and intolerance in older adults

Lactose malabsorption and intolerance in older adults

The Contribution of Type 2 Diabetes to Parkinson’s Disease Aetiology

Evaluation of bidirectional gut‐brain axis and anorectal function in Parkinson's disease with constipation

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