Parkinson`s disease and occupational exposure to organic solvents, agricultural chemicals and mercury--a case-referent study.

Ohlson, Carl‐Göran; Hogstedt, Christer

doi:10.5271/sjweh.2549

Cited by 50 publications

(28 citation statements)

References 11 publications

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“…Occupational exposure to organic solvents was associated with increased risk of PD in two case-control studies [154,309] whilst in another study, the increased risk was confined to men [292]. Six other case-control studies, including the large (767 cases) European multicentre study [300], observed no association between organic solvents and PD [300,308,310,313,317,393]. One case-control study found an increased risk with longer duration of exposure (OR 3.59, 95% CI 1.26-19.26 for 20-30 years of exposure versus not exposed, p for trend 0.04) although no association was observed overall [381].…”

Section: Organic Solventsmentioning

confidence: 99%

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

et al. 2011

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Section: Organic Solventsmentioning

confidence: 99%

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

et al. 2011

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“…However, the relationship between occupational exposure to specific metals and PD has been examined infrequently in case-control studies with sizeable populations (table 1) [9][10][11][12][13][14]. Findings in these studies have also varied, most likely due to methodological differences, such as the locale and nature of the populations examined, the criteria used for the diagnosis of PD and the means of exposure assessment.…”

Section: Introductionmentioning

confidence: 99%

“…With regard to mercury, Ohlson and Hogstedt [14], in a hospital-based case-control study in Sweden, found no group difference in occupational exposure to the metal. Seidler et al [10] reported elevated but nonsignificant Ever-exposure to lead associated with PD only by comparison with regional control group.…”

Section: Occupational Exposure To Specific Metals and The Risk Of Pdmentioning

confidence: 99%

Occupational Metal Exposures and the Risk of Parkinson’s Disease

et al. 1999

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Occupational exposure to specific metals (manganese, copper, lead, iron, mercury, zinc, aluminum and others) appears to be a risk factor for Parkinson’s disease (PD) in some, but not all, case-control studies. These epidemiological studies are reviewed. Several methodological issues that may account for the lack of unanimity of findings are discussed, and suggestions for improved case-control methodology are offered. The study of the neurological disease outcome of workers who have had long-term, well-defined occupational exposure to one or more metals is also urged, with collaborative work including industrial hygienists, occupational toxicologists, neurologists, epidemiologists and biostatisticians. Such efforts, employing state-of-the-art case and control ascertainment and enrollment from suitable population bases, neurological diagnostic rigor and exposure assessment, will help to further define the potentially important roles played by metals in PD and other neurodegenerative disorders.

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“…The association of PD and mercury has been rarely reported or investigated [10]. Ohlson and Hogstedt [10] suggested a possi ble positive association (crude odds ratio, OR = 2.4; and 95% confidence intervals, Cl = 0.5-5.0) between mercury exposure and PD and other forms of parkinsonism, al though body burden mercury levels in their study subjects were not assayed.…”

Section: Introductionmentioning

confidence: 99%

“…Several environmental factors, like pre vious exposure to toxins, pesticides, virus and smoking, have been investigated in an attempt to elucidate the etiology of idio pathic Parkinson's disease (PD) [1][2][3][4][5][6][7][8][9][10]. Caine et al [1] postulated that PD and sev eral other related neurological conditions may be due to environmental damage to spe-ciftc regions of the central nervous system.…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic Study on the Association between Body Burden Mercury Level and Idiopathic Parkinson's Disease

Ngim¹,

Devathasan

1989

Neuroepidemiology

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A case-control study was conducted among the multiethnic population of Singapore to test the hypothesis that a high level of body burden mercury is associated with an increased risk of Parkinson''s disease (PD). Selected factors investigated that could contribute to the body burden of mercury included dietary fish intake, ethnic over-the-counter medications, occupational exposures and possession of dental amalgam fillings. Detailed interviews were completed in 54 cases of idiopathic PD and 95 hospital-based controls, matched for age, sex and ethnicity, between July 1985 and July 1987. After adjusting for potential confounding factors, including dietary fish intake, medications, smoking and alcohol consumption, there was clear monotonic dose-response association between PD and blood mercury levels. The odds ratios (OR) and 95% confidence intervals (CI) for the approximate subject tertiles based upon blood mercury levels were 8.5 (CI = 2.2–33.2) and 9.4 (CI = 2.5–35.9), relative to the tertile with lowest blood mercury levels (< 5.8 ng Hg/ml). Similar associations were revealed using scalp hair and urinary mercury levels. However, only the comparisons between the highest and lowest tertiles were statistically different from unity (p < 0.05). When the body burden mercury indicators were mutually adjusted in addition to the four confounding factors, blood and urinary mercury levels showed ORs of 21.00 and 18.65, respectively. These ORs were statistically different from unity (p < 0.05, 2-sided test). After adjustment, scalp hair mercury was shown to be a poor predictor of PD risk.

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Parkinson`s disease and occupational exposure to organic solvents, agricultural chemicals and mercury--a case-referent study.

Abstract: Parkinson`s disease and occupational exposure to organic solvents, agricultural chemicals and mercury--a case-referent study. by Ohlson C-G, Hogstedt CThe following article refers to this text: 2017;43(3):191-289

Cited by 50 publications

References 11 publications

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Occupational Metal Exposures and the Risk of Parkinson’s Disease

Epidemiologic Study on the Association between Body Burden Mercury Level and Idiopathic Parkinson's Disease

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