Parkinson's disease as a result of aging

Rodrı́guez, Manuel; Rodriguez-Sabate, Clara; Moráles, Ingrid; Sánchez, Ana María Sánchez; Sabaté, Magdalena

doi:10.1111/acel.12312

Cited by 181 publications

(155 citation statements)

References 389 publications

(489 reference statements)

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“…The subsequent oxidative stress will then facilitate the aggregation of α-synuclein (Takahashi et al, 2007). Aggregation of α-synuclein forms Lewy bodies and Lowy neurites, both of which are hallmarks of PD (Rodriguez et al, 2016; Rodriguez et al, 2015). …”

Section: Nvu Impairment Is a Cause Rather Than A Consequence In Agmentioning

confidence: 99%

Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect

Cai

Zhang

et al. 2017

Ageing Research Reviews

238

184

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Current understanding on the mechanisms of brain injury and neurodegeneration highlights an appreciation of multicellular interactions within the neurovascular unit (NVU), which include the evolution of blood-brain barrier (BBB) damage, neuronal cell death or degeneration, glial reaction, and immune cell infiltration. Aging is an important factor that influences the integrity of the NVU. The age-related physiological or pathological changes in the cellular components of the NVU have been shown to increase the vulnerability of the NVU to ischemia/reperfusion injury or neurodegeneration, and to result in deteriorated brain damage. This review describes the impacts of aging on each NVU component and discusses the mechanisms by which aging increases NVU sensitivity to stroke and neurodegenerative diseases. Prophylactic or therapeutic perspectives that may delay or diminish aging and thus prevent the incidence of these neurological disorders will also be reviewed.

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Section: Nvu Impairment Is a Cause Rather Than A Consequence In Agmentioning

confidence: 99%

Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect

Cai

Zhang

et al. 2017

Ageing Research Reviews

238

184

View full text Add to dashboard Cite

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“…), which are protective for WM oligodendrocytes and axons, is reduced in aged astrocytes (Deierborg et al, 2008; Lin et al, 1993; Saavedra et al, 2006). Aged brains exhibit a decrease in the ability of astrocytes to remove toxic molecules from the extracellular medium, including α-synuclein (Braak et al, 2007; Lee et al, 2010; Song et al, 2009) and glutamate (Morales et al, 2013; Rodriguez et al, 2015). Notably, one study documented an increase in astrocyte activation in the aged brain, and this was accompanied by a significant decline in the expression of myelin proteins (Bates et al, 2013).…”

Section: White Matter Changes In the Normal Aging Brainsmentioning

confidence: 99%

Aging of cerebral white matter

Liu

Yang

Xia

et al. 2017

Ageing Research Reviews

218

141

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White matter (WM) occupies a large volume of the human cerebrum and is mainly composed of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are the structural foundation for efficient neurotransmission between cortical and subcortical areas. Similar to neuron-enriched gray matter areas, WM undergoes a series of changes during the process of aging. WM malfunction can induce serious neurobehavioral and cognitive impairments. Thus, age-related changes in WM may contribute to the functional decline observed in the elderly. In addition, aged WM becomes more susceptible to neurological disorders, such as stroke, traumatic brain injury (TBI), and neurodegeneration. In this review, we summarize the structural and functional alterations of WM in natural aging and speculate on the underlying mechanisms. We also discuss how age-related WM changes influence the progression of various brain disorders, including ischemic and hemorrhagic stroke, TBI, Alzheimer’s disease, and Parkinson’s disease. Although the physiology of WM is still poorly understood relative to gray matter, WM is a rational therapeutic target for a number of neurological and psychiatric conditions.

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“…While age-related changes and disease severity are commonly known to affect mobility and gait in PD (Rodriguez et al, 2015; Dewey et al, 2014), recent evidence suggests that cognitive function may also play a role (Smulders et al, 2013). In contrast to other neurodegenerative conditions which primarily feature cognitive deficits (such as Alzheimer disease), the cognitive profile in PD is more heterogeneous, likely reflecting the more variable underlying neuropathology (Lin & Wu, 2015; Burdick et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Investigation of factors impacting mobility and gait in Parkinson disease

Christofoletti

McNeely

Campbell

et al. 2016

Human Movement Science

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Mobility and gait limitations are major issues for people with Parkinson disease (PD). Identification of factors that contribute to these impairments may inform treatment and intervention strategies. In this study we investigated factors that predict mobility and gait impairment in PD. Participants with mild to moderate PD and without dementia (n=114) were tested in one session ‘off’ medication. Mobility measures included the 6-Minute Walk test and Timed-Up-and-Go. Gait velocity was collected in four conditions: forward preferred speed, forward dual task, forward fast as possible and backward walking. The predictors analyzed were age, gender, disease severity, balance, balance confidence, fall history, self-reported physical activity, and executive function. Multiple regression models were used to assess the relationships between predictors and outcomes. The predictors, in different combinations for each outcome measure, explained 55.7% to 66.9% of variability for mobility and 39.5% to 52.8% for gait velocity. Balance was the most relevant factor (explaining up to 54.1% of variance in mobility and up to 45.6% in gait velocity). Balance confidence contributed to a lesser extent (2.0% to 8.2% of variance) in all models. Age explained a small percentage of variance in mobility and gait velocity (up to 2.9%). Executive function explained 3.0% of variance during forward walking only. The strong predictive relationships between balance deficits and mobility and gait impairment suggest targeting balance deficits may be particularly important for improving mobility and gait in people with PD, regardless of an individual’s age, disease severity, fall history, or other demographic features.

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Parkinson's disease as a result of aging

Cited by 181 publications

References 389 publications

Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect

Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect

Aging of cerebral white matter

Investigation of factors impacting mobility and gait in Parkinson disease

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