Parkinson’s disease-associated 18 bp promoter variant of DJ-1 alters REST binding and regulates its expression

Pal, Prosenjit; Roy, Souvik; Chowdhury, Anindya Roy; Chatterjee, Raghunath; Ray, Kunal; Ray, Jharna

doi:10.1016/j.neulet.2023.137051

Cited by 1 publication

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“…DJ-1 protein, also called oxidation-sensitive protein, is widely expressed in neurons and glial cells in the brain and exerts neuroprotective effects during neurodegeneration [ 26 ]. A previous study demonstrated that the level of DJ-1 in the CSF of patients with PD was reduced compared with that in the CSF of HCs [ 27 ]. DJ-1 has been linked to oxidative stress and mitochondrial homeostasis in PD cells; therefore, it has potential in cellular metabolic pathology [ 28 , 29 ].…”

Section: Biomarkers In Body Fluidsmentioning

confidence: 99%

Biomarkers of Parkinson’s Disease: From Basic Research to Clinical Practice

2023

Aging dis

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Parkinson's disease (PD) is a common neurodegenerative disease characterized pathologically by dopaminergic neuron loss and the formation of Lewy bodies, which are enriched with aggregated α-synuclein (α-syn). PD currently has no cure, but therapeutic strategies are available to alleviate symptoms. Early diagnosis can greatly improve therapeutic interventions, but the clinical diagnosis of PD remains challenging and depends mainly on clinical features and imaging tests. Efficient and specific biomarkers are crucial for the diagnosis, monitoring, and evaluation of PD. Here, we reviewed the biomarkers of PD in different tissues and biofluids, along with the current clinical biochemical detection methods. We found that the sensitivity and specificity of single biomarkers are limited, and selecting appropriate indicators for combined detection can improve the diagnostic accuracy of PD.

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Section: Biomarkers In Body Fluidsmentioning

confidence: 99%

Biomarkers of Parkinson’s Disease: From Basic Research to Clinical Practice

2023

Aging dis

View full text Add to dashboard Cite

show abstract

Parkinson’s disease-associated 18 bp promoter variant of DJ-1 alters REST binding and regulates its expression

Cited by 1 publication

References 41 publications

Biomarkers of Parkinson’s Disease: From Basic Research to Clinical Practice

Biomarkers of Parkinson’s Disease: From Basic Research to Clinical Practice

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