Parkinson's disease: From bench to bedside

Draoui, Ahmed; Hiba, Omar El; Aimrane, Abdelmohcine; Khiat, Abdelaati El; Gamrani, Halima

doi:10.1016/j.neurol.2019.11.002

Cited by 66 publications

(29 citation statements)

References 103 publications

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“…PD is the most common movement disorder and the second most common ND. The incidence of PD is eight to 18 per 100,000 person-years overall, and prevalence reaches 1% in subjects over 60 years and 3% over 80 years with a higher incidence in men than in women [15]. As in other NDs, there are two forms: the sporadic form, which represents 90% of the cases, with an early onset, and the familial form, which represents 10-15% of the cases with an onset beyond 50 years [16,17].…”

Section: Parkinson's Diseasementioning

confidence: 99%

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Bordoni

Scarian

Rey

et al. 2020

IJMS

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Neurodegenerative disorders (i.e., Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and spinal cord injury) represent a great problem worldwide and are becoming prevalent because of the increasing average age of the population. Despite many studies having focused on their etiopathology, the exact cause of these diseases is still unknown and until now, there are only symptomatic treatments. Biomaterials have become important not only for the study of disease pathogenesis, but also for their application in regenerative medicine. The great advantages provided by biomaterials are their ability to mimic the environment of the extracellular matrix and to allow the growth of different types of cells. Biomaterials can be used as supporting material for cell proliferation to be transplanted and as vectors to deliver many active molecules for the treatments of neurodegenerative disorders. In this review, we aim to report the potentiality of biomaterials (i.e., hydrogels, nanoparticles, self-assembling peptides, nanofibers and carbon-based nanomaterials) by analyzing their use in the regeneration of neural and glial cells their role in axon outgrowth. Although further studies are needed for their use in humans, the promising results obtained by several groups leads us to suppose that biomaterials represent a potential therapeutic approach for the treatments of neurodegenerative disorders.

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Section: Parkinson's Diseasementioning

confidence: 99%

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Bordoni

Scarian

Rey

et al. 2020

IJMS

View full text Add to dashboard Cite

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“…Some of the disease-related symptoms can be treated pharmacologically ( 1 , 22 ) or by deep brain stimulation [DBS; ( 23 , 24 )], whereas other symptoms respond only limitedly, negatively, or not at all to PD medication ( 3 , 6 , 10 , 25 ) and/or DBS ( 23 , 26 – 28 ). Furthermore, for the treatment of cognitive dysfunction, only limited pharmacologic options exist ( 6 , 29 , 30 ).…”

Section: Introductionmentioning

confidence: 99%

“…This results in an increased cognitive load, an increased risk for errors/failure, and fatigue ( 11 , 45 ). Additionally, the cognitive impairment itself, which can even occur in PD patients before or at the time of the diagnosis ( 3 , 21 ), might influence movement planning and execution ( 11 , 45 , 46 ), all together limiting patients' (re-) learning potential. However, several studies have shown that (re-)learning is possible in PD ( 39 , 42 , 47 – 50 ).…”

Section: Introductionmentioning

confidence: 99%

Feasibility of Music-Assisted Treadmill Training in Parkinson's Disease Patients With and Without Deep Brain Stimulation: Insights From an Ongoing Pilot Randomized Controlled Trial

et al. 2020

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Conclusion: MATT was shown to be a feasible, safe, and enjoyable treatment option in PD patients with and without DBS. Furthermore, the dropout cohort analysis revealed some exciting first insights into possible dropout reasons that go beyond the form of intervention. Therefore, research would benefit from a common practice of dropout analyses, as this would enhance our understanding of patients' therapy adherence and expectations.

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“…In addition, most patients also have movement or non movement symptoms, mainly manifested in intermittent gait restriction or obstruction during walking, especially in turning, walking and obstacle avoidance, which seriously endangers people's living ability [2,3]. The progress of population aging and the increasing incidence rate of PD suggest that it is very important for PD to prevent, treat and delay the progress of the disease [4].…”

Section: Introductionmentioning

confidence: 99%

Improvement of Freezing of Gait in Patients with Parkinson's Disease by Music Exercise Therapy: A Study Protocol for a Randomized Controlled Trial

Zhou

et al. 2020

Preprint

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Background: Freezing of gait, a common pathological gait in Parkinson's disease, is progressive with the progression of the disease. It is an important risk factor for patients to fall easily, lose their independent living ability and decline their quality of life. The treatment of Parkinson's disease with freezing of gait is very difficult, and the effect of medicine and operation is not ideal. Music exercise therapy is a kind of treatment technology that can change the behavior, emotion and physiological activity of patients by listening to music at the same time of exercise therapy. In recent years, music exercise therapy has been widely used in motor disorders and neurological diseases, and has achieved remarkable results. The small sample study in the early stage of this research group initially found that music exercise therapy can improve the freezing of gait of Parkinson's patients and improve the quality of life of patients. The overall purpose of this experiment is to expand the sample size to further evaluate the clinical effect of music exercise therapy on freezing of gait of Parkinson's patients.Methods/design: This randomized controlled trial will evaluate the clinical efficacy of music exercise therapy in improving the freezing of gait of Parkinson's patients. The patients will receive music exercise therapy, exercise therapy without music and routine rehabilitation therapy at random. We will recruit 81 inpatients of Parkinson's who meet the trial criteria to observe the changes of gait and limb motor function after 4 weeks of intervention. The first evaluation index is to use three-dimensional gait analysis system to evaluate the change of patients' gait. The second evaluation index includes limb function, activity of daily living and fall risk assessment.Discussion: Our aim is to evaluate the efficacy of music exercise therapy in the treatment of Parkinson's patients with freezing of gait. This result will provide more evidence for the clinical application of this therapy in the future.Trial registration: The trial has been registered at the Chinese Clinical Trial Registry (http://www.chictr.org.cn) on September 20, 2019. Registration number: ChiCTR1900026063

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Parkinson's disease: From bench to bedside

Cited by 66 publications

References 103 publications

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach

Feasibility of Music-Assisted Treadmill Training in Parkinson's Disease Patients With and Without Deep Brain Stimulation: Insights From an Ongoing Pilot Randomized Controlled Trial

Improvement of Freezing of Gait in Patients with Parkinson's Disease by Music Exercise Therapy: A Study Protocol for a Randomized Controlled Trial

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