Parkinson's Disease Patients with Dominant Hemibody Affected by the Disease Rely More on Vision to Maintain Upright Postural Control

Lahr, J.; Pereira, Marcelo Pinto; Pelicioni, Paulo Henrique Silva; Morais, Luana Carolina de; Gobbi, Lilian Teresa Bucken

doi:10.2466/15.pms.121c26x0

Cited by 10 publications

(9 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Integration of visual sensory information is essential for appropriate movement initiation and execution. Inferior temporal lobe dysfunction may influence motor function and daily activities through impaired processing of visual information (37,42). How does aberrant brain activity of this zone affect motor function in LPD patients needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…It is well-known that the left inferior temporal lobe is critical for semantic integration and visual processing ( 40 , 41 ). Lahr et al ( 42 ) have demonstrated that PD patients relied on visual input to maintain upright postural control. Integration of visual sensory information is essential for appropriate movement initiation and execution.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Abnormal Spontaneous Brain Activity in Left-Onset Parkinson Disease: A Resting-State Functional MRI Study

Chen

et al. 2020

Front. Neurol.

View full text Add to dashboard Cite

Objective: Motor asymmetry is characteristic in Parkinson disease (PD). This phenomenon is originated from uneven degeneration of bilateral substantia nigra. However, this asymmetry may not restrict to substantia nigra or striatum. We aimed to determine the effect of asymmetry on spontaneous brain activity across the whole brain. Methods: We consecutively recruited 71 patients with PD, as well as 35 healthy controls, and collected relevant demographic, clinical, and neuropsychological information. The PD patients were divided into two groups according to the side of motor symptom onset. All the participants underwent resting-state functional magnetic resonance imaging, and spontaneous brain activity was assessed using amplitude of low-frequency fluctuation (ALFF). The associations between areas showing significant group differences and various clinical and neuropsychological measures were analyzed. Results: Finally, the data of 30 PD patients with left-onset (LPD), 27 PD patients with right-onset (RPD), and 32 healthy controls were obtained. The three groups had similar age and gender ratios. Our results demonstrated that LPD patients had increased ALFF in the left inferior temporal gyrus and decreased ALFF in bilateral thalamus and cerebellum anterior lobes than the control group. The value of ALFF of the left inferior temporal gyrus was correlated with motor function, and ALFF value of the thalamus was associated with cognition. Comparisons between LPD and RPD patients and between RPD patients and the controls did not yield significant difference. Conclusions: The present study provides new insights into the distinct characteristics of spontaneous brain activity in LPD, which may be associated with motor and cognitive function.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Abnormal Spontaneous Brain Activity in Left-Onset Parkinson Disease: A Resting-State Functional MRI Study

Chen

et al. 2020

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…Regarding the PD population, limited research supports that FP measures may identify balance impairments, even in early disease stages, and may detect balance decline with disease progression [32–35]. Rossi-Izquierdo et al [36] found that the SOT and LOS test differentiated between PD and healthy groups and between fallers from nonfallers within the PD cohort.…”

Section: Introductionmentioning

confidence: 99%

Comparing Balance Performance on Force Platform Measures in Individuals with Parkinson’s Disease and Healthy Adults

Harro

Kelch

Hargis

et al. 2018

Parkinson's Disease

View full text Add to dashboard Cite

Introduction Postural instability is a known contributing factor to balance dysfunction and increased fall risk in those with Parkinson's disease (PD). Computerized posturography employing a force platform system provides objective, quantitative assessments of postural control impairments. This study examines balance performance as measured by force platform (FP) tests in persons with PD compared to age-matched healthy adults. Secondarily, we examine if these FP measures provide diagnostic and clinically meaningful information about the underlying balance impairments in the PD population. Methods Participants—42 individuals with PD (Hoehn and Yahr stage = 2.33 ± 0.77) and 55 age-matched healthy adults—were assessed on three standardized balance measures on a computerized force platform system. Between groups, comparisons of FP performance were analyzed using independent t-test. Within the group, comparisons for the PD cohort were analyzed using ANOVA for comparing disease stage and Mann–Whitney U test for PD subtypes. Results The PD cohort demonstrated significantly greater postural instability on the sensory organization test (SOT) measures (P=0.013, CI-95% = 1.286 to 10.37) and slower movement velocity on the limits of stability (LOS) test (P=0.001, CI-95% = 0.597 to 1.595) than the healthy cohort, suggesting that these tests were sensitive to detect sensory integration and voluntary postural control deficits in the PD cohort. Within the PD group, the SOT differentiated between H&Y stages 1–3. The motor control test (MCT) detected changes in reactive postural control mainly in later disease stages. All three FP tests distinguished between PD subtypes, with the Posture Gait Instability subtype demonstrating poorer balance performance than Tremor Dominant subtype. Conclusion These findings suggest FP measures provide clinically meaningful, diagnostic information in the examination of balance impairments in individuals with PD. FP measures may inform clinicians regarding intrinsic balance deficits and guide them in designing targeted balance interventions to reduce fall risk in persons with PD.

show abstract

“…Lahr et al [6], for example, showed that PD subjects presented a higher reliance on vision on the dominant side to compensate somatosensory system impairments. Vibrotactile neurofeedback, known to stimulate the proprioception of the subjects, has been proven beneficial to subjects with PD [7].…”

Section: Introductionmentioning

confidence: 99%

Postural instability in subjects with Parkinson’s disease undergoing different sensory pitfalls

et al. 2018

View full text Add to dashboard Cite

Purpose. Previous research has reported postural instability in subjects with Parkinson's disease (PD). However, there are still doubts about the effect of sensory stimuli on one's balance. In this study, we further investigated the stabilometric measures of individuals with PD, analysing the impact of different sensory stimuli on the outcomes. Methods. The total of 26 participants (13 with PD and 13 matched control peers) were submitted to 8 sensorimotor dynamics differing in relation to support base (30 cm vs. 10 cm, feet in parallel vs. feet in semi-tandem position), contact surface (foam vs. no foam), and visual conditions (eyes open vs. eyes closed). The measures used to assess one's balance were body position in space, area of support base, and velocity of postural control. The variables involved the anterior-posterior and the mediolateral axes. Participants with PD were evaluated during the off medication state. Mann-Whitney U test and Friedman's test were applied to carry out inter-and intra-group comparisons. Significance was set at 5%. Results. Cross-sectional analyses illustrated that tasks with sensory pitfalls impacted postural stability to a larger extent in PD subjects. The differences were found in anterior-posterior body position, area of support base, anterior-posterior velocity, and mediolateral velocity. Complementary analyses confirmed considerable instability on balance when support bases were small and visual information was absent (p < 0.05). Conclusions. The current results confirm worse postural stability response in subjects with PD and highlight that the interference of the sensory pitfalls is notable when individuals are off medication.

show abstract

Parkinson's Disease Patients with Dominant Hemibody Affected by the Disease Rely More on Vision to Maintain Upright Postural Control

Cited by 10 publications

References 40 publications

Abnormal Spontaneous Brain Activity in Left-Onset Parkinson Disease: A Resting-State Functional MRI Study

Abnormal Spontaneous Brain Activity in Left-Onset Parkinson Disease: A Resting-State Functional MRI Study

Comparing Balance Performance on Force Platform Measures in Individuals with Parkinson’s Disease and Healthy Adults

Postural instability in subjects with Parkinson’s disease undergoing different sensory pitfalls

Contact Info

Product

Resources

About