Parkinson’s disease (PD) with dementia and falls is improved by AChEI? A preliminary study report

Lauretani, Fulvio; Galuppo, Laura; Cipolla, Costantino; Ticinesi, Andrea; Ceda, Gian Paolo; Ruffini, Livia; Nardelli, Anna; Maggio, Marcello

doi:10.1007/s40520-015-0437-x

Cited by 12 publications

(10 citation statements)

References 23 publications

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“…Therefore, the effect of carvacrol on memory improvement could be due to its anticholinesterase activity and modulation of the cholinergic system. In agreement with this, it has been reported that acetylcholinesterase inhibitors have a beneficial effect on cognitive performance in PD 36 .…”

Section: Discussionsupporting

confidence: 84%

Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease

Haddadi

Rajaei

Alaei

et al. 2018

Arq. Neuro-Psiquiatr.

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The present study investigated the effects of carvacrol on motor and memory deficits as well as hyperalgesia in the 6-OHDA-lesioned rat model of Parkinson's disease. The animals were subjected to unilateral microinjection of 6-OHDA into the medial forebrain bundle and treated with carvacrol (25, 50 and 100 mg/kg, ip) for six weeks after surgery. The 6-OHDA-lesioned rats showed contralateral rotations towards the lesion side, which was accompanied by learning and memory deficits in a passive avoidance test and a decrease in tail withdrawal latency in a tail flick test at the end of week 6. The results also showed that treatment with carvacrol at a dose of 25 mg/kg ameliorated memory deficits, with no effect on rotations and hyperalgesia in lesioned rats. In conclusion, carvacrol improves memory impairments in rats with Parkinson's disease; therefore, it may serve as an adjunct therapy for the alleviation of memory deficits in Parkinson's disease patients.

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Section: Discussionsupporting

confidence: 84%

Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease

Haddadi

Rajaei

Alaei

et al. 2018

Arq. Neuro-Psiquiatr.

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“…OM of gait may have a future role in the assessment of PD as there is evidence that some interventions may improve gait stability and balance. 14 , 15 OM of gait parameters can already, in some specific situations, influence PD management decisions. 15 , 16 If effective treatment is developed for any of these PD symptoms, they may become useful targets for OM.…”

Section: What Should Be Measured In Pd?mentioning

confidence: 99%

Viewpoint and practical recommendations from a movement disorder specialist panel on objective measurement in the clinical management of Parkinson’s disease

Odin

Chaudhuri

Volkmann³

et al. 2018

npj Parkinson's Disease

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Motor aspects of Parkinson’s disease, such as fluctuations and dyskinesia, can be reliably evaluated using a variety of “wearable” technologies, but practical guidance on objective measurement (OM) and the optimum use of these devices is lacking. Therefore, as a first step, a panel of movement disorder specialists met to provide guidance on how OM could be assessed and incorporated into clinical guidelines. A key aspect of the incorporation of OM into the management of Parkinson’s disease (PD) is defining cutoff values that separate “controlled” from “uncontrolled” symptoms that can be modified by therapy and that relate to an outcome that is relevant to the person with PD (such as quality of life). Defining cutoffs by consensus, which can be subsequently tested and refined, is the first step to optimizing OM in the management of PD. OM should be used by all clinicians that treat people with PD but the least experienced may find the most value, but this requires guidance from experts to allow non-experts to apply guidelines. While evidence is gained for devices that produce OM, expert opinion is needed to supplement the evidence base.

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“…1 Postural control is severely reduced in PD and postural instability is thought to be one of the main symptoms of the disease. [2][3][4] Walking speed is reduced in PD patients and this is accompanied by a decrease in arm swing.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, there is an increase in cadence, double support, and left-right gait asymmetry and there is a decrease in bilateral coordination. 1 Gait disorders and postural instability increase the risk of falls in PD, which causes severe head trauma, fractures and mortality. 1 In addition, levodopa-induced dyskinesia, symptomatic orthostatic hypotension, sudden loss of postural reflexes, coexisting neurological or other medical disorders, and environmental factors are the other risk factors for falls in PD.…”

Section: Introductionmentioning

confidence: 99%

“…1 Gait disorders and postural instability increase the risk of falls in PD, which causes severe head trauma, fractures and mortality. 1 In addition, levodopa-induced dyskinesia, symptomatic orthostatic hypotension, sudden loss of postural reflexes, coexisting neurological or other medical disorders, and environmental factors are the other risk factors for falls in PD. 5,6 In the majority of the studies, the falls are related to the cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

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Persistent Monoarthritis on the Patient of Parkinson’s Disease with Cognitive Impairment and Frequent Falls

Çelik

Ilhanli

Uysal

et al. 2017

IPMRJ

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Parkinson's disease (PD) is often associated with cognitive impairment and frequent falls. Although the cause of frequent falls is not clearly understood, cognitive impairment is thought to be the cause of frequent falls and these frequent falls can lead to serious complications such as traumatic arthritis. Traumatic arthritis is a wellknown condition that develops in the joints as a result of recurrent trauma. Here we presented a 61-year-old female patient with PD who suffered from severe pain, limitation, swelling, temperature increase and erythema of right knee also difficulty of gait. In the result of all the detailed evaluations made, conservative treatment-resistant traumatic monoarthritis and osteonecrosis were diagnosed due to recurrent falls of the patient and the patient was directed to surgical treatment. The patient's falls were ongoing due to cognitive impairment and PD and she continued to suffer from pain and swelling despite performing unicompartmental (lateral compartment) knee arthroplasty. As a result of consultations with orthopaedists we decided to perform a total knee arthroplasty on the patient. After surgery, the patient was admitted to our rehabilitation clinic for orthopedic and PD rehabilitation program. During the rehabilitation program, the symptoms of swelling and pain in the patient's knee improved and the frequency of falls decreased. The patient's rehabilitation program still continues in our clinic.

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Parkinson’s disease (PD) with dementia and falls is improved by AChEI? A preliminary study report

Abstract: We hypothesize that AchEI could improve stability, balance and postural instability in addition to cognitive performance in PD with MCI and balance deficits.

Cited by 12 publications

References 23 publications

Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease

Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease

Viewpoint and practical recommendations from a movement disorder specialist panel on objective measurement in the clinical management of Parkinson’s disease

Persistent Monoarthritis on the Patient of Parkinson’s Disease with Cognitive Impairment and Frequent Falls

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