Parkinson's disease with a predominant right-sided putaminal FP-CIT SPECT deficiency shows stronger decline of asymmetry over time

Pedrosa, David J.; Kahraman, Deniz; Schmidt, Matthias; Drzezga, Alexander; Timmermann, Lars; Eggers, Carsten

doi:10.1016/j.baga.2014.08.001

Cited by 3 publications

(2 citation statements)

References 37 publications

(41 reference statements)

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“…Some studies have suggested that the asymmetric onset of PD is not random but is directed by brain lateralization (i.e. hand dominance) 13 , 14 . Explanations have been sought amongst structural and biochemical hemispheric differences that may cause specific unilateral vulnerabilities for PD pathology 15 .…”

Section: Introductionmentioning

confidence: 99%

Investigating the aspect of asymmetry in brain-first versus body-first Parkinson’s disease

Lövdal,

Carli,

Orso

et al. 2024

npj Parkinsons Dis.

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Parkinson’s disease (PD) is characterized by a progressive loss of dopaminergic neurons in the substantia nigra. Recent literature has proposed two subgroups of PD. The “body-first subtype” is associated with a prodrome of isolated REM-sleep Behavior Disorder (iRBD) and a relatively symmetric brain degeneration. The “brain-first subtype” is suggested to have a more asymmetric degeneration and a prodromal stage without RBD. This study aims to investigate the proposed difference in symmetry of the degeneration pattern in the presumed body and brain-first PD subtypes. We analyzed 123I-FP-CIT (DAT SPECT) and 18F-FDG PET brain imaging in three groups of patients (iRBD, n = 20, de novo PD with prodromal RBD, n = 22, and de novo PD without RBD, n = 16) and evaluated dopaminergic and glucose metabolic symmetry. The RBD status of all patients was confirmed with video-polysomnography. The PD groups did not differ from each other with regard to the relative or absolute asymmetry of DAT uptake in the putamen (p = 1.0 and p = 0.4, respectively). The patient groups also did not differ from each other with regard to the symmetry of expression of the PD-related metabolic pattern (PDRP) in each hemisphere. The PD groups had no difference in symmetry considering mean FDG uptake in left and right regions of interest and generally had the same degree of symmetry as controls, while the iRBD patients had nine regions with abnormal left–right differences (p < 0.001). Our findings do not support the asymmetry aspect of the “body-first” versus “brain-first” hypothesis.

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Section: Introductionmentioning

confidence: 99%

Investigating the aspect of asymmetry in brain-first versus body-first Parkinson’s disease

Lövdal,

Carli,

Orso

et al. 2024

npj Parkinsons Dis.

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“…Ainda neste sentido, estudos utilizando técnicas patológicas e diagnóstico por imagem, mostram que nos pacientes com DP, as lesões na parte compacta da substância negra se apresentam de forma assimétrica, mostrando diferenças de volume 48 e atividade 49 , quando comparados os lados D/E [50][51][52] , além de neurodegeneração assimétrica nas vias nigrostriatais no estágio inicial da DP 51 , diferentemente de controles saudáveis 47 .…”

Section: Acreditamos Que Os Achados Da Fraqueza Muscular Presentes No...unclassified

Assimetria dos sintomas motores nos estágios iniciais da doença de Parkinson

Ribeiro¹

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Hemispheric Network Expression in Parkinson’s Disease: Relationship to Dopaminergic Asymmetries

Tang

Holtbernd

et al. 2020

JPD

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Background: Parkinson’s disease (PD) is characterized by brain metabolic networks, specifically associated with motor and cognitive manifestations. Few studies have investigated network changes in cerebral hemispheres ipsilateral and contralateral to the clinically more affected body side. Objective: We examined hemispheric network abnormalities and their relationship to striatal dopaminergic deficits in PD patients at different stages. Methods: 45 PD patients underwent dual-tracer positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) and 18F-fluorodopa (FDOPA) in a high-resolution PET scanner. In all patients, we computed expression levels for the PD-related motor/cognition metabolic patterns (PDRP/PDCP) as well as putamen/caudate FDOPA uptake values in both hemispheres. Resulting hemispheric measures in the PD group were compared with corresponding healthy control values and assessed across disease stages. Results: Hemispheric PDRP and PDCP expression was significantly elevated contralateral and ipsilateral to the more affected body side in patients with unilateral symptoms (H&Y 1: p < 0.01) and in patients with bilateral limb involvement (H&Y 2-3: p < 0.001; H&Y 4: p < 0.003). Elevations in pattern expression were symmetrical at all disease stages. By contrast, FDOPA uptake in the caudate and putamen was reduced bilaterally (p < 0.002), with lower values on both sides at more advanced disease stages. Hemispheric uptake was asymmetrical in both striatal regions, with lower contralateral values at all disease stages. The magnitude of hemispheric uptake asymmetry was smaller with more advanced disease, reflecting greater change ipsilaterally. Conclusion: Symmetrical network expression in PD represents bilateral functional effects unrelated to nigrostriatal dopaminergic asymmetries.

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Parkinson's disease with a predominant right-sided putaminal FP-CIT SPECT deficiency shows stronger decline of asymmetry over time

Cited by 3 publications

References 37 publications

Investigating the aspect of asymmetry in brain-first versus body-first Parkinson’s disease

Investigating the aspect of asymmetry in brain-first versus body-first Parkinson’s disease

Assimetria dos sintomas motores nos estágios iniciais da doença de Parkinson

Hemispheric Network Expression in Parkinson’s Disease: Relationship to Dopaminergic Asymmetries

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