Parkinson's disease

Bloem, Bastiaan R.; Okun, Michael S.; Klein, Christine

doi:10.1016/s0140-6736(21)00218-x

Cited by 1,903 publications

(1,476 citation statements)

References 163 publications

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“…The PN is widely considered to be an important primary point of contact for PwPs and care partner alike. PNs are also recognized to be very helpful in the role of a multidisciplinary care team coordinator [93]. When PNs are available to provide home-based care, it has been shown that patients' quality of life improves [54,94].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the emerging possibility of remote patient monitoring (i.e., smart glasses, smart beds or wearables [83,100]), we emphasize future research on up-to-date tech-based home-based care solutions and the future role a PN may hold in this scenario of increasingly techbased medical and social care delivery. This demand would also meet the need of care approaches to not only being responsive to specific care situations, but to incorporate proactive elements, such as the utilization of telemedicine [92,93].…”

Section: Discussionmentioning

confidence: 99%

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Moving towards Integrated and Personalized Care in Parkinson’s Disease: A Framework Proposal for Training Parkinson Nurses

Munster

Stümpel

Thieken

et al. 2021

JPM

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Delivering healthcare to people living with Parkinson’s disease (PD) may be challenging in face of differentiated care needs during a PD journey and a growing complexity. In this regard, integrative care models may foster flexible solutions on patients’ care needs whereas Parkinson Nurses (PN) may be pivotal facilitators. However, at present hardly any training opportunities tailored to the care priorities of PD-patients are to be found for nurses. Following a conceptual approach, this article aims at setting a framework for training PN by reviewing existing literature on care priorities for PD. As a result, six prerequisites were formulated concerning a framework for training PN. The proposed training framework consist of three modules covering topics of PD: (i) comprehensive care, (ii) self-management support and (iii) health coaching. A fourth module on telemedicine may be added if applicable. The framework streamlines important theoretical concepts of professional PD management and may enable the development of novel, personalized care approaches.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Moving towards Integrated and Personalized Care in Parkinson’s Disease: A Framework Proposal for Training Parkinson Nurses

Munster

Stümpel

Thieken

et al. 2021

JPM

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“…The degeneration of midbrain dopaminergic (DA) neurons within the pars compacta region of the substantia nigra (SNpc) is a pathological hallmark of Parkinson's disease (PD) and Lewy body dementia (LBD) 1 . Nonetheless, some SNpc neurons are observed to survive even into late stages of disease [2][3][4][5][6][7] , suggesting differential vulnerability to degeneration.…”

Section: Introductionmentioning

confidence: 99%

A molecular census of midbrain dopaminergic neurons in Parkinson’s disease

Kamath

Abdulraouf

Burris

et al. 2021

Preprint

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Midbrain dopamine (DA) neurons in the substantia nigra pars compacta (SNpc) project widely throughout the central nervous system, playing critical roles in voluntary movements, reward processing, and working memory. Many of these neurons are highly sensitive to neurodegeneration in Parkinson's Disease (PD), and their loss correlates strongly with the pathognomonic symptoms. To characterize these populations molecularly, we developed a protocol to enrich and transcriptionally profile DA neuron nuclei from postmortem human SNpc of both PD patients and matched controls. We identified a total of ten distinct populations, including one that was primate-specific. A single subtype, marked by the gene AGTR1, was highly susceptible to degeneration, and was enriched for expression of genes associated with PD in genetic studies, suggesting many risk loci act within this subtype to influence its neurodegeneration. The AGTR1 subtype also showed the strongest upregulation of TP53 and its downstream targets, nominating a potential pathway of degeneration in vivo. The transcriptional characterization of differentially disease-vulnerable DA neurons in the SNpc will inform the development of laboratory models, enable the nomination of novel disease biomarkers, and guide further studies of pathogenic disease mechanisms.

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“…The number of studies on the non-pharmacological treatment of PD is limited (n = 4). Although globally, the research on non-pharmacological interventions is less extensive than pharmacological treatment, it has been documented to be beneficial for PD patients [156]. Therefore, developing Romanian research in this domain would be beneficial.…”

Section: Discussionmentioning

confidence: 99%

Parkinson’s Disease in Romania: A Scoping Review

et al. 2021

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Parkinson’s disease (PD) is a significant cause of disability, with a fast-growing prevalence. This review summarizes the epidemiological and clinical data, research on the diagnostic approaches and the interventions available in the Eastern European country of Romania. This scoping review follows the recommendations on the scoping review methodology by Joanna Briggs Institute. We searched four databases (up to 27 January 2021). The data of eligible studies were extracted in standardized forms. We identified 149 unique studies from 1133 records, with 11 epidemiological studies, 52 studies investigating clinical aspects of PD, 35 studies on diagnostic tools, and 51 intervention studies. A narrative synthesis is provided and placed in a historical context. Our review revealed a considerable increase in the Romanian research on PD in the latest 15 years, which largely follows international trends. However, we also identified several research gaps that provide useful information for policymakers, public health specialists, and clinicians.

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Parkinson's disease

Cited by 1,903 publications

References 163 publications

Moving towards Integrated and Personalized Care in Parkinson’s Disease: A Framework Proposal for Training Parkinson Nurses

Moving towards Integrated and Personalized Care in Parkinson’s Disease: A Framework Proposal for Training Parkinson Nurses

A molecular census of midbrain dopaminergic neurons in Parkinson’s disease

Parkinson’s Disease in Romania: A Scoping Review

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