Parkinsonian impairment correlates with spatially extensive subthalamic oscillatory synchronization

Pogosyan, Alek; Yoshida, Fumiaki; Chen, C. C.; Martínez‐Torres, Irene; Foltynie, Thomas; Limousin, Patricia; Zrinzo, Ludvic; Hariz, Marwan; Brown, Peter

doi:10.1016/j.neuroscience.2010.08.068

Cited by 97 publications

(78 citation statements)

References 59 publications

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“…In PD, for example, an increased connectivity between the cortex and the STN with respect to healthy subjects has been shown in functional MRI (fMRI) studies [54,55,56]. This increased connectivity seems to be related to the onset of phase coherence in the beta band (13-35 Hz) observed in these patients, which has been, in fact, correlated with the severity of tremor, bradykinesia and rigidity that they present [57]. Other studies have shown an increase in connectivity between the supplementary motor and primary motor areas and the cerebellum, as well as decreased connectivity between the putamen and cerebellum.…”

Section: Discussionmentioning

confidence: 99%

Integrating Diffusion Tensor Imaging-Based Tractography into Deep Brain Stimulation Surgery: A Review of the Literature

Torres¹,

Manzanares

Sola³

2014

Stereotact Funct Neurosurg

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Background: It has been generally accepted that deep brain stimulation (DBS) not only acts in the nucleus where it is being applied, as initially thought, but that chronic stimulation activates axons located in its scope, and that this activation can exert its effects in distant areas. Considering this, DBS target identification should be made based on techniques that identify white matter tracts, such as tractography, rather than only by identifying specific nuclei on conventional magnetic resonance imaging. Methods: In this study, we performed a review of the literature on the use of tractography in DBS surgery and provide an overview of the main results. Results: Tractography has been used in the field of DBS to help clarify relevant aspects in the selection of targets and in evaluating its therapeutic effects in movement disorders, psychiatric diseases and pain. Conclusions: Studies are scarce so far, but they have provided data that, if confirmed, may optimize DBS surgery. Tractography might become a routine tool for DBS surgery in the near future.

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Section: Discussionmentioning

confidence: 99%

Integrating Diffusion Tensor Imaging-Based Tractography into Deep Brain Stimulation Surgery: A Review of the Literature

Torres¹,

Manzanares

Sola³

2014

Stereotact Funct Neurosurg

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“…They are stable and robust in the long term and can be recorded from the same electrodes used for clinical DBS making them attractive targets for biomarkers 8 . In addition to beta oscillations, a range of other, more complex, potential biomarkers have been identified that have been shown to relate to severity of symptoms 2,[9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Little

Pogosyan

Neal³

et al. 2014

JoVE

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Adaptive deep brain stimulation (aDBS) has the potential to improve the treatment of Parkinson's disease by optimizing stimulation in real time according to fluctuating disease and medication state. In the present realization of adaptive DBS we record and stimulate from the DBS electrodes implanted in the subthalamic nucleus of patients with Parkinson's disease in the early post-operative period. Local field potentials are analogue filtered between 3 and 47 Hz before being passed to a data acquisition unit where they are digitally filtered again around the patient specific beta peak, rectified and smoothed to give an online reading of the beta amplitude. A threshold for beta amplitude is set heuristically, which, if crossed, passes a trigger signal to the stimulator. The stimulator then ramps up stimulation to a pre-determined clinically effective voltage over 250 msec and continues to stimulate until the beta amplitude again falls down below threshold. Stimulation continues in this manner with brief episodes of ramped DBS during periods of heightened beta power.Clinical efficacy is assessed after a minimum period of stabilization (5 min) through the unblinded and blinded video assessment of motor function using a selection of scores from the Unified Parkinson's Rating Scale (UPDRS). Recent work has demonstrated a reduction in power consumption with aDBS as well as an improvement in clinical scores compared to conventional DBS. Chronic aDBS could now be trialed in Parkinsonism.

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“…Investigation in rat and nonhuman primate models (Bergman et al, 1994;Breit et al, 2007;Tai et al, 2003;Vila et al, 2000) and human PD patients (Pogosyan et al, 2010) showed that the death of DA cells in the SNc may provoke changes of the firing rate and firing pattern of STN neurons and characteristic changes in motor behavior. However, due to the complex organization of BG and the variety of receptors it is difficult to determine the net effects produced by 6-OHDA or MPTP lesion of DA cells in SNc.…”

Section: Introductionmentioning

confidence: 99%

Dopamine deficiency increases synchronized activity in the rat subthalamic nucleus

Lintas¹,

Силькис²,

Albèri³

et al. 2012

Brain Research

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Abnormal neuronal activity in the subthalamic nucleus (STN) plays a crucial role in the pathophysiology of Parkinson's disease (PD). In this study we investigated changes in rat STN neuronal activity after 28 days following the injection of 6-OHDA in the substantia nigra pars compacta (SNc). This drug provoked a lesion of SNc that induced a dopamine and lesioned (n = 83) groups was similar, as well as the firing rate. In 6-OHDA treated rats we observed a significant increase (from 26% to 48%) in the number of pairs with synchronous firing. These data suggest that the synchronous activity of STN cells, provoked by loss of DA cells in SNc, is likely to be among the most significant dysfunctions in the basal ganglia of Parkinsonian patients. We raise the hypothesis that in normal conditions, DA maintains a balance between funneling information via the hyperdirect cortico-subthalamic pathway and parallel processing through the parallel cortico-basal ganglia-subthalamic pathways, both of which are necessary for selected motor behaviors..

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Parkinsonian impairment correlates with spatially extensive subthalamic oscillatory synchronization

Cited by 97 publications

References 59 publications

Integrating Diffusion Tensor Imaging-Based Tractography into Deep Brain Stimulation Surgery: A Review of the Literature

Integrating Diffusion Tensor Imaging-Based Tractography into Deep Brain Stimulation Surgery: A Review of the Literature

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Dopamine deficiency increases synchronized activity in the rat subthalamic nucleus

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