Parkinsonism as a manifestation of brain tumor

Polyzoidis, Konstantinos S.; McQueen, James; Rajput, A. H.; MacFadyen, D.J.

doi:10.1016/0090-3019(85)90161-2

Cited by 45 publications

(27 citation statements)

References 12 publications

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“…Complete resection of the angioma was required before the symptoms (resting tremor, cogwheel rigidity, and akinesia) gradually improved [5]. It has been previously reported that one of the criteria for the diagnosis of tumor-induced parkinsonism is reversibility of clinical findings after tumor resection [4,5,6, 9]. Similarly, our patient also experienced complete cessation of the resting tremor upon gross, total surgical resection of the pineal lesion.…”

Section: Discussionsupporting

confidence: 52%

“…Brain tumors causing secondary parkinsonism have previously been reported in the literature [2,3,4,5], but most reports are of supratentorial tumors with compression or infiltration of the basal ganglia or compression of the brainstem [6, 7]. The tumors most often associated with secondary parkinsonism are large meningiomas, growing over the frontal convexity or at the skull base, including the sphenoid ridge [2, 6, 7].…”

Section: Introductionmentioning

confidence: 99%

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Resting Tremor Secondary to a Pineal Cyst: Case Report and Review of the Literature

Morgan¹,

Scumpia

Webster

et al. 2008

Pediatr Neurosurg

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Background: Patients with pineal lesions typically present with the classical signs of increased intracranial pressure (headache, nausea, vomiting) and/or Parinaud’s syndrome. Rare symptomatology of secondary parkinsonism attributed to pineal lesions has been previously reported in the literature. We describe an unusual case of a pineal cyst in a patient with the presenting sign of a resting tremor. Case Description: We report an 18-year-old Caucasian female who presented with a 1-month history of a new-onset progressive, unilateral low-frequency right-hand resting tremor with associated headache, nausea, vomiting, and excessive diarrhea. Magnetic resonance imaging demonstrated an atypical appearance with enhancement of a mildly prominent pineal gland, possibly representing a pineal cyst. The patient did not exhibit radiographic signs of hydrocephalus. Based upon the radiographic appearance, one could not exclude with absolute certainty the presence of a malignancy. The patient ultimately underwent a bilateral suboccipital craniotomy with gross total resection of the lesion. Postoperatively, the patient exhibited immediate resolution of her preoperative resting tremor and continues to be symptom free at 1 year. Conclusions: A new-onset, resting tremor and/or other secondary parkinsonism symptoms should raise clinical suspicions of pineal lesions. Treatment can be guided based on tissue type and the presence or absence of hydrocephalus. We observed that complete surgical resection of the lesion provided the best treatment option for the total resolution of symptoms attributed to the disturbance of the microvasculature surrounding the nigro-striatal-pallidal system.

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Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Resting Tremor Secondary to a Pineal Cyst: Case Report and Review of the Literature

Morgan¹,

Scumpia

Webster

et al. 2008

Pediatr Neurosurg

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“…5,16 Overall, taking into account the rarity of basal ganglia tumors, parkinsonian movement disorders appear to be more frequently secondary to supratentorial tumors sparing the basal ganglia. 3,4 Parkinsonism associated with mass lesions of the infratentorial compartment is unusual. The earliest notion of such a case was by Blocq and Marinesco in 1893.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] Most tumors causing parkinsonism are large, supratentorial, extra-axial neoplasms or, more rarely, intra-axial neoplasms that typically spare the basal ganglia. 3,4 Parkinsonian symptoms in these patients are secondary to compression or distortion of the basal ganglia or their circuitry. Intrinsic basal ganglia tumors usually do not result in parkinsonism.…”

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confidence: 99%

Parkinsonism in children resulting from mesencephalic tumors

Pohle

Krauss

1999

Mov. Disord.

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“…Other chemicals that have been reported to cause parkinsonism include carbon disul® de, methanol, n-hexane and paint thinner (Adler, 1999;Kopin, 1987;Sanchez-Ramos, 1993). Other causes of parkinsonism include structural lesions, vascular insults, hydrocephalus, infection, trauma and metabolic disorders (Adler, 1999;Hurtig, 1993;Polyzoidis et al, 1985;Sweeney, 1993). Some of these alternative causes of parkinsonism may respond to levodopa and thus, it is imperative that the clinician identify the offending agent or abnormality so that appropriate therapy can be instituted.…”

Section: Pd and Parkinsonismmentioning

confidence: 99%

Parkinson's disease: clinical manifestations and treatment

Dawson

2000

International Review of Psychiatry

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This review describes and synthesizes the clinical manifestations, differential diagnosis, and treatment of Parkinson's disease (PD). PD is a common neurodegenerative disorder affecting approximately 0.5 to 1% of the population over the age of 65.The cardinal features of PD include tremor, bradykinesia, rigidity and postural instability.There are also a number of secondary features that are important to recognize and treat, including cognitive dysfunction, depression, anxiety, autonomic dysfunction, and disturbances of sleep. Only approximately 75± 80% of patients that present with parkinsonian features have idiopathic PD. Other disease entities that can present with parkinsonism are reviewed. It is important to recognize these disorders since treatment and prognosis for the parkinsonian syndromes are markedly different from idiopathic PD. In addition, current medical and surgical approaches for the treatment of PD are reviewed.The mainstay of treatment for PD remains levodopa, but there are a number of supplementary medications including anticholinergics and dopamine agonists, which are useful in the treatment of PD. Surgical approaches including thalamotomy, pallidotomy and deep brain stimulation are receiving increased attention as adjunctive therapy for treatment of PD.

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Parkinsonism as a manifestation of brain tumor

Cited by 45 publications

References 12 publications

Resting Tremor Secondary to a Pineal Cyst: Case Report and Review of the Literature

Resting Tremor Secondary to a Pineal Cyst: Case Report and Review of the Literature

Parkinsonism in children resulting from mesencephalic tumors

Parkinson's disease: clinical manifestations and treatment

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