Parkinsonism induced by solvent abuse

Uitti, Ryan J.; Snow, Barry; Shinotoh, Hitoshi; Vingerhoets, François; Hayward, Margo; Hashimoto, S. A.; Richmond, John C.; Markey, Sanford P.; Markey, Carol; Calne, Donald B.

doi:10.1002/ana.410350516

Cited by 62 publications

(23 citation statements)

References 12 publications

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“…In fact, clinical studies have demonstrated that parkinsonism is found in patients with long-term occupational exposure to solvents, including toluene, xylene, methyl-ethylketone, methanol, n-hexane and carbon disulfide [8, 9]. We could not identify the causal constitution of the solvents in the present cases, because both patients had been exposed to several different solvents for more than 20 years.…”

Section: Discussioncontrasting

confidence: 41%

Loss of Postural Reflexes in Long-Term Occupational Solvent Exposure

Kuriwaka¹,

Mitsui²,

Fujiwara³

et al. 2002

Eur Neurol

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Inhalation of organic solvents has long been known to damage various nervous systems, including cerebellum, brainstem, and pyramidal tract. However, little is known about the damage of the dopaminergic system. We report two patients with occupational long-term solvent exposure who developed postural instability without other features of parkinsonism. The concentration of HVA in CSF was decreased and the retropulsion was dramatically improved after the administration of levodopa. These findings indicate that the nigrostriatal dopaminergic neurons were disturbed by chronic solvent exposure, resulting in the loss of postural reflexes.

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Section: Discussioncontrasting

confidence: 41%

Loss of Postural Reflexes in Long-Term Occupational Solvent Exposure

Kuriwaka¹,

Mitsui²,

Fujiwara³

et al. 2002

Eur Neurol

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“…In 2004, the lifetime prevalence of inhalant use among 8 th graders (17.3%) nationally exceeded the prevalences for marijuana (16.3%), amphetamines (7.5%), hallucinogens (3.5%), cocaine (3.4%), and heroin (1.6%) . Recurrent inhalant use is associated with serious health problems including cerebellar ataxia, Parkinsonism, encephalopathy, trigeminal neuropathy, hepatorenal syndrome, hepatotoxicity, and "sudden sniffing death" (Brett, 1997;Meadows and Verghese, 1996;Utti et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Psychiatric disorders in inhalant users: Results from The National Epidemiologic Survey on Alcohol and Related Conditions

Howard

2007

Drug and Alcohol Dependence

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Objective-To examine the prevalence and correlates of mood, anxiety, and personality disorders among lifetime inhalant users.Methods-Statistical analyses were based on data from the 2001─2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a nationally representative survey of adults in the United States.Results-Inhalant users (N = 664) had high lifetime prevalences of DSM-IV mood (48%), anxiety (36%), and personality (45%) disorders. Of all inhalant users, 70% met criteria for at least one lifetime mood, anxiety, or personality disorder and 38% experienced a mood or anxiety disorder in the past year. Prevalences of comorbid psychiatric disorders varied by gender. Compared with male inhalant users, female inhalant users had higher prevalences of lifetime dysthymia (24% vs. 16%), any anxiety disorder (53% vs. 30%), panic disorder without agoraphobia (25% vs. 11%), and specific phobia (28% vs. 14%), but a lower prevalence of antisocial personality disorder (22% vs.36%). Female inhalant users also were more likely than male inhalant users to meet criteria for three or more mood or anxiety disorders (15% vs. 8%) in the past year. Among inhalant users with comorbid disorders, those who developed social or specific phobia typically experienced onset of these disorders prior to initiation of inhalant use; all other mood and anxiety disorders usually developed following the onset of inhalant use. Inhalant users who were women, poor, less educated, with early onset of inhalant use, family histories of psychopathology, and personal histories of substance abuse treatment had increased odds of psychiatric disorders.Conclusions-Psychiatric disorders are highly prevalent among inhalant users nationally and female inhalant users are more likely than male inhalant users to experience multiple psychiatric disorders. Inhalant use and its consequences among females warrant greater research attention.

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“…Over the past 100 years, there have been a number of reports of acute parkinsonism occurring in individuals exposed to large amounts of solvents, including methanol [12], n-hexane [13] and hydrocarbon solvent mixtures [14][15][16]. However, the syndromes caused by these intoxications were almost always distinct from PD in both their clinical phenomenology and neuropathology.…”

mentioning

confidence: 99%

Trichloroethylene and Parkinson’s disease: dissolving the puzzle

Goldman¹

2010

Expert Review of Neurotherapeutics

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Parkinsonism induced by solvent abuse

Cited by 62 publications

References 12 publications

Loss of Postural Reflexes in Long-Term Occupational Solvent Exposure

Loss of Postural Reflexes in Long-Term Occupational Solvent Exposure

Psychiatric disorders in inhalant users: Results from The National Epidemiologic Survey on Alcohol and Related Conditions

Trichloroethylene and Parkinson’s disease: dissolving the puzzle

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