PARN Maintains RNA Stability to Regulate Insulin Maturation and GSIS in Pancreatic β Cells
Xiaomei Xie,
Xuexue Chen,
Chaofan Wang
et al.
Abstract:Diabetes, a metabolic disorder characterized by hyperglycemia, underscores the importance of normal pancreatic β‐cell development and function in maintaining glucose homeostasis. Poly(A)‐specific ribonuclease (PARN) serves as the principal regulator of messenger RNA (mRNA) stability, yet its specific role in pancreatic β cells remains unclear. This study utilizes mice with targeted PARN deficiency in β cells to elucidate this role. Notably, Parn conditional knockout mice present unaltered β‐cell development an… Show more
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